scholarly journals Improving molecularly imprinted nanogels by pH modulation

RSC Advances ◽  
2015 ◽  
Vol 5 (110) ◽  
pp. 91018-91025 ◽  
Author(s):  
Zijie Zhang ◽  
Juewen Liu
Keyword(s):  
Specific Binding ◽  
Template Molecule ◽  
Molecularly Imprinted

Non-specific binding between template molecule and the imprinted gel is significantly reduced by pH modulation.

scholarly journals Synthesis of Molecularly Imprinted Polymerand its Molecular Recognition PropertiesofN-Acetylneuraminic Acid

2007 ◽  
Vol 4 (4) ◽  
pp. 611-619 ◽  
Author(s):  
Hsin-Hung Pan ◽  
Wen-Chien Lee ◽  
Chin-Yin Hung ◽  
Ching-Chiang Hwang
Keyword(s):  
Specific Binding ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Acetylneuraminic Acid ◽  
Binding Isotherms ◽  
Molecular Imprinting Technique ◽  
Guest System ◽  
Cross Linker ◽  
Principal Advantage

A molecular imprinting technique was applied in this work to detectN-acetylneuraminic acid (Neu5Ac) and its analogue structure. Twomolecularly imprinted polymers (MIP) were prepared using Neu 5Ac as the template molecule, as well as methacrylic acid (MAA) or 4-vinylpyridine (4-Vpy) and ethyleneglycol dimethacrylate (EGDMA) as the functionalmonomer and cross-linker, respectively. Free radical polymerization was carried out at 4°C under UV radiation or thermal (60°C) polymerization. MIP thus obtained were ground into 11∼25µm and 25-44µm. The binding results from Neu5Ac solution, mannose (Man) solution andN-acetyl-Dmannosamine (ManNAc) solution performed by Neu5Ac-MIP showed specific binding toward Neu5Ac rather than other analogue compounds on the host-guest system. The values of capacity for Neu5Ac-MIP were measured and experimental results were further used for simulation to obtain the binding isotherms. The principal advantage of this method is thatNeu5Ac- MIP can recognize Neu5Ac and its analogue compounds.

Preparation of carbon-based metal organic frameworks modified molecularly imprinted polymers for selective recognition of bovine hemoglobin in biological samples

2022 ◽  
Author(s):  
Xue Chen ◽  
Jinyue Chai ◽  
Baodong Sun ◽  
Xue Yang ◽  
Feng Zhang ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Metal Organic Framework ◽  
Selective Recognition ◽  
Template Molecule ◽  
Bovine Hemoglobin ◽  
Carbon Spheres ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Metal Organic ◽  
Carbon Based

In this study, the carbon-based Cu2+-immobilized metal-organic framework modified molecularly imprinted polymer (C@GI@Cu-MOFs@MIPs) adsorbent was prepared using bovine hemoglobin (BHb) as a template molecule with carbon spheres as carriers for...

scholarly journals Molecular imprinting of hydrogels : improved drug delivery vehicles

2021 ◽  
Author(s):  
Kristin L McBain
Keyword(s):  
Drug Uptake ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Polymer Backbone ◽  
Molecularly Imprinted ◽  
Drug Delivery Vehicles ◽  
Hydrogel Polymers ◽  
Delivery Vehicles ◽  
Uptake Studies ◽  
Langmuir And Freundlich Models

The present study aimed to characterize and evaluate the ability of two molecularly imprinted hydrogel polymers to uptake drug template molecules from solution. A copolymer of methyl methacrylate (MMA) and N, N-Dimethyl acrylamide (DMAA), and a homopolymer of 2-hydroxyethyl methacrylate (HEMA) were synthesized. Both polymer types were either molecularly imprinted (MIP) with a drug template molecule (propranolol, naproxen or timolol) or prepared without a template (non-imprinted polymer, NIP). The polymers were characterized by water content, FTIR, DSC, XRD, and SEM. With the exception of the SEM data, no differences between MIPs and NIPs were noted. Polymers were used in template re-uptake studies and their isotherms fit to Langmuir and Freundlich models. Based on the results. we conclude that the MMA-DMAA ProMIP was most successful at rebinding propranolol compared to the corresponding NIP. By changing the composition of the polymer backbone the drug uptake ability of the polymer changes drastically.

scholarly journals Removal of bisphenol A from aqueous media using a highly selective adsorbent of hybridization cyclodextrin with magnetic molecularly imprinted polymer

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
S. Mamman ◽  
F. B. M. Suah ◽  
M. Raaov ◽  
F. S. Mehamod ◽  
S. Asman ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Molecularly Imprinted Polymer ◽  
Binding Capacity ◽  
Bulk Polymerization ◽  
Resonance Spectroscopy ◽  
Template Molecule ◽  
Order Kinetic ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Magnetic Molecularly Imprinted Polymer

In this study, a unique magnetic molecularly imprinted polymer (MMIP) adsorbent towards bisphenol A (BPA) as a template molecule was developed by bulk polymerization using β-cyclodextrin (β-CD) as a co-monomer with methacrylic acid (MAA) to form MMIP MAA–βCD as a new adsorbent. β-CD was hybridized with MAA to obtain water-compactible imprinting sites for the effective removal of BPA from aqueous samples. Benzoyl peroxide and trimethylolpropane trimethacrylate were used as the initiator and cross-linker, respectively. The adsorbents were characterized by Fourier transform infrared spectroscopy, scanning electronic microscopy, transmission electron microscopy, vibrating sample magnetometer, Brunauer–Emmett–Teller and X-ray diffraction. 1 H nuclear magnetic resonance spectroscopy was used to characterize the MAA–βCD and BPA–MAA–βCD complex. Several parameters influencing the adsorption efficiency of BPA such as adsorbent dosage, pH of sample solution, contact time, initial concentrations and temperature as well as selectivity and reusability study have been evaluated. MMIP MAA–βCD showed significantly higher removal efficiency and selective binding capacity towards BPA compared to MMIP MAA owing to its unique morphology with the presence of β-CD. The kinetics data can be well described by the pseudo second-order kinetic and Freundlich isotherm and Halsey models best fitted the isotherm data. The thermodynamic studies indicated that the adsorption reaction was a spontaneous and exothermic process. Therefore, MMIP based on the hybrid monomer of MAA–βCD shows good potential of a new monomer in molecularly imprinted polymer preparation and can be used as an effective adsorbent for the removal of BPA from aqueous solutions.

Application of Response Surface Methodology to Synthesize Appropriate Molecularly Imprinted Polymer for Diazinon

2014 ◽  
Vol 605 ◽  
pp. 67-70 ◽  
Author(s):  
Mohsen Rahiminezhad ◽  
Seyed Jamaleddin Shahtaheri ◽  
Mohammad Reza Ganjali ◽  
Abbas Rahimi Rahimi Forushani
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Capillary Electrochromatography ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Molecular Imprinting Technology ◽  
Cross Linker

Molecular imprinting technology has become an interesting research area to the preparation of specific sorbent material for environmental and occupational sample preparation techniques (1). In the molecular imprinting technology, specific binding sites have been formed in polymeric matrix, which often have an affinity and selectivity similar to antibody-antigen systems (2). In molecular imprinted technology, functional monomers are arranged in a complementary configuration around a template molecule, then, cross-linker and solvent are also added and the mixture is treated to give a porous material containing nono-sized binding sites. After extraction of the template molecule by washing, vacant imprinted sites will be left in polymer, which are available for rebinding of the template or its structural analogue (3). The stability, convention of preparation and low cost of these materials make them particularly attractive (4). These synthetic materials have been used for capillary electrochromatography (5), chromatography columns (6), sensors (7), and catalyze system (8). Depending on the molecular imprinting approach, different experimental variables such as the type and amounts of functional monomers, porogenic solvent, initiator, monomer to cross-linker ratio, temperature, and etc may alter the properties of the final polymeric materials. In this work, chemometric approach based on Central Composite Design (CCD) was used to design the experiments as well as to find the optimum conditions for preparing appropriate diazinon molecularly imprinted polymer.

Fluorescence signaling molecularly imprinted polymers for antibiotics prepared via site-directed post-imprinting introduction of plural fluorescent reporters within the recognition cavity

2016 ◽  
Vol 4 (44) ◽  
pp. 7138-7145 ◽  
Author(s):  
Hirobumi Sunayama ◽  
Takeo Ohta ◽  
Atsushi Kuwahara ◽  
Toshifumi Takeuchi
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Fluorescent Dyes ◽  
Specific Binding ◽  
Fluorescence Signal ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Fluorescent Reporters ◽  
Binding Event ◽  
Fluorescence Signaling

An antibiotic-imprinted cavity with two different fluorescent dyes was prepared by molecular imprinting and subsequent post-imprinting modifications (PIMs), for the readout of a specific binding event as a fluorescence signal.

Inorganic-Framework Molecularly Imprinted CdS/TiO2 for Selectively Photocatalytic Degradation of Di (2-ethylhexyl) phthalate

2019 ◽  
Vol 41 (2) ◽  
pp. 308-308
Author(s):  
Fangyan Chen Fangyan Chen ◽  
Yiming Liu Yiming Liu ◽  
Xi Zhang Xi Zhang ◽  
Lina He and Yubin Tang Lina He and Yubin Tang
Keyword(s):  
Photoelectron Spectroscopy ◽  
Tetrabutyl Titanate ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
X Ray ◽  
Simulated Solar Light ◽  
Specific Recognition ◽  
Vis Spectroscopy ◽  
Inorganic Framework ◽  
Ethylhexyl Phthalate

In order to improve the photocatalytic efficiency and selectivity of di (2-ethylhexyl) phthalate (DEHP) under solar-driven, the inorganic-framework molecularly imprinted CdS/TiO2, named as MIP-CdS/TiO2, was prepared by using DEHP as template molecule and tetrabutyl titanate as titanium source and functional monomer. The as-prepared MIP-CdS/TiO2 was characterized by scanning electron microscopy (SEM), X-ray energy spectrum (EDS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), UV-Vis Spectroscopy (UV-vis), X-ray photoelectron spectroscopy (XPS) and photoluminescence spectrum (PL). And the specific recognition and photocatalytic selectivity of MIP-CdS/TiO2 to DEHP were investigated. The results show that inorganic-framework molecular imprinting on the surface of CdS/TiO2 can result in existence of specific recognition sites of DEHP, extend and intensify the absorption visible light of CdS/TiO2, inhibit the recombination of the photo-induced electron-holes pairs. MIP-CdS/TiO2 has a specific recognition to DEHP. The binding selectivity coefficients of DEHP relative to its analogues DBP and DMP are 2.78 and 2.60, respectively. Compared with CdS/TiO2, MIP-CdS/TiO2 exhibits higher photocatalytic activity and selectivity for DEHP. Under simulated solar light irradiation, the degradation efficiency of DEHP photocatalyzed by MIP-CdS/TiO2 is 75.5%, which is 1.63 times as high as that of DEHP photocatalyzed by CdS/TiO2.

scholarly journals A Simple and Efficient Molecularly Imprinted Electrochemical Sensor for the Selective Determination of Tryptophan

Biomolecules ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 294 ◽  
Author(s):  
Tian ◽  
Deng ◽  
Wu ◽  
Ding ◽  
Li ◽  
...  
Keyword(s):  
Crosslinking Agent ◽  
Pharmaceutical Preparations ◽  
Chitosan Film ◽  
Template Molecule ◽  
Serum Samples ◽  
Solution Ph ◽  
Molecularly Imprinted ◽  
Functional Polymer ◽  
Selective Determination

In this paper, a tryptophan (Trp) molecularly imprinted chitosan film was prepared on the surface of an acetylene black paste electrode using chitosan as the functional polymer, Trp as the template molecule and sulfuric acid as the crosslinking agent. The surface morphologies of non-imprinted and imprinted electrodes were characterized by scanning electron microscopy (SEM). The formation of hydrogen bonds between the functional polymer and the template molecule was confirmed by infrared spectroscopy. Some factors affecting the performance of the imprinted electrode such as the concentration of chitosan, the mass ratio of chitosan to Trp, the dropping amount of the chitosan-Trp mixture, the solution pH, and the accumulation potential and time were discussed. The experimental results show that the imprinted electrode exhibit good affinity and selectivity for Trp. The dynamic linear ranges of 0.01–4 M, 4–20 M and 20–100 M were obtained by second derivative linear sweep voltammetry, and the detection limit was calculated to be 8.0 nM. The use of the imprinted electrode provides an effective method for eliminating the interference of potentially interfering substances. In addition, the sensor has high sensitivity, reproducibility and stability, and can be used for the determination of Trp in pharmaceutical preparations and human serum samples.

Synthesis and Characteristic of Molecularly Imprinted Polymer Immobilized Mesoporous Silica Sphere for Selective Binding of S-Naproxen

2008 ◽  
Vol 47-50 ◽  
pp. 890-893
Author(s):  
Nai Ci Bing ◽  
Zhen Tian ◽  
Sheng Wen Chen ◽  
Qing Hua Li ◽  
Zheng Liang Xu
Keyword(s):  
Mesoporous Silica ◽  
Binding Capacity ◽  
Stationary Phases ◽  
Chiral Separations ◽  
Silica Sphere ◽  
Template Molecule ◽  
Structural Morphology ◽  
Molecularly Imprinted ◽  
Surface Imprinting Technique ◽  
Mesoporous Silica Sphere

Molecularly imprinted composite materials (PM) selective to S-naproxen were prepared in the surface of mesoporous silica sphere (SBA-15) by surface imprinting technique. FT-IR, SEM and surface area analysis were used to study the structural morphology of PM and MIPs particles and probe the incorporation of polymer into the SBA-15 framework. The results revealed that PM showed better binding affinity and selectivity to the template molecule than MIPs and the maximum saturated binding capacity of PM to S-naproxen and R-naproxen was about 10.3332 and 6.0063µmol·g-1. Meanwhile, we achieve a reference strategy for the development of molecularly imprinting polymer for drugs and to handle forms in certain applications such as chromatographic stationary phases for chiral separations.

Cholesterol-Imprinted Receptor Using Chitosan Derivative as the Precursor

2013 ◽  
Vol 699 ◽  
pp. 712-717
Author(s):  
Huai Min Guan ◽  
Yue Jin Tong ◽  
Jin Hua Zheng ◽  
Xiang Li
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Polar Solvent ◽  
Binding Capacity ◽  
Template Molecule ◽  
Chitosan Derivative ◽  
Amino Groups ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Selective Protection ◽  
Selection Of

Research has been focused on the development of molecularly imprinted polymers using a chitosan derivative as the precursor. An O-acyl chitosan was synthesized by the selective protection of amino groups of chitosan in MeSO3H and was cross-linked with glutaraldehyde in the presence/ absence of template molecule, cholesterol. The effect of the degree of the acyl substitution on the selection of precursor was investigated, regarding the solubility of chitosan derivative, interaction between the precursor and imprinted molecule, and degree of the cross-linking of precursor. The rebinding experiments indicated the significant recognition for cholesterol with imprinted polymer as compared with non-imprinted polymer. It was found that a good binding capacity of the imprinted polymer towards cholesterol could be achieved in a less-polar solvent. And the O-acyl chitosan-based molecularly imprinted polymer obtained displayed good recognition selectivity for cholesterol in comparison to similarly strctural analogue, cholesterol acetate.

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