Recyclable organocatalyst-promoted one-pot Michael/aza-Henry/lactamization reactions for fluorinated 2-piperidinones bearing four stereogenic centres

RSC Advances ◽  
2015 ◽  
Vol 5 (87) ◽  
pp. 71071-71075 ◽  
Author(s):  
Xin Huang ◽  
Kenny Pham ◽  
Xiaofeng Zhang ◽  
Wen-Bin Yi ◽  
Jeremy H. Hyatt ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Efficient Method ◽  
One Pot ◽  
Highly Efficient

A highly efficient method for asymmetric synthesis of fluorinated 2-piperidinones bearing four stereogenic centres is introduced.

Green One-Pot Asymmetric Synthesis of Peptidomimetics via Sequential Organocatalyzed Aziridination and Passerini Multicomponent Reaction

Synthesis ◽  
2019 ◽  
Vol 52 (07) ◽  
pp. 1076-1086
Author(s):  
Deborah A. dos Santos ◽  
Allan R. da Silva ◽  
Javier Ellena ◽  
Cecilia C. P. da Silva ◽  
Marcio W. Paixão ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Protease Inhibitors ◽  
Multicomponent Reaction ◽  
Efficient Method ◽  
Cysteine Protease ◽  
Heterocyclic Compounds ◽  
Solvent Mixture ◽  
Cysteine Protease Inhibitors ◽  
One Pot ◽  
Sequential Reaction

Peptidomimetics containing an aziridine moiety have been reported as potent cysteine protease inhibitors. In this sense, the development of stereoselective and sustainable synthetic strategies to obtain three-membered N-heterocyclic compounds has gained importance in the last decades. In this work, an efficient method was designed to achieve highly functionalized aziridine peptidomimetics via a sequential reaction, which involves the organocatalytic aziridination of α,β-unsaturated aldehydes followed by the Passerini multicomponent reaction in an environmentally friendly solvent mixture (ethanol: water).

A highly efficient asymmetric synthesis of quaternary stereocenter-containing indolizidine and quinolizidine alkaloids using aldehydes, nitroalkenes, and unactivated cyclic ketimines

2014 ◽  
Vol 50 (100) ◽  
pp. 15913-15915 ◽  
Author(s):  
Yu Tan ◽  
Yong-Jian Chen ◽  
Hua Lin ◽  
Han-Lin Luan ◽  
Xing-Wen Sun ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Quinolizidine Alkaloids ◽  
One Pot ◽  
Efficient Approach ◽  
Highly Efficient ◽  
Quaternary Stereocenter

A highly efficient approach to the construction of indolizidines and quinolizidines bearing a bridged quaternary stereocenter has been established in a one-pot fashion using aldehydes, nitroalkenes, and cyclic ketimines.

SnCl4 or TiCl4: highly efficient catalysts for the detetrahydropyranylation and demethoxymethylation of phenolic ethers and sequential one-pot asymmetric synthesis of 3-aryl-2-hydroxy-2,3-dihydroindan-1-ones from chalcone epoxides

RSC Advances ◽  
2015 ◽  
Vol 5 (77) ◽  
pp. 63095-63103 ◽  
Author(s):  
Naseem Ahmed ◽  
Gulab Khushalrao Pathe ◽  
Sohan Jheeta
Keyword(s):  
Asymmetric Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Highly Efficient

SnCl4 or TiCl4 catalysts provide a rapid and efficient detetrahydropyranylation and demethoxymethylation of phenolic ethers and a sequential one-pot intramolecular Friedel–Crafts alkylation of chalcone epoxides under mild reaction conditions.

scholarly journals Highly selective synthesis of 2,5-bis(aminomethyl)furan via catalytic amination of 5-(hydroxymethyl)furfural with NH3 over a bifunctional catalyst

RSC Advances ◽  
2019 ◽  
Vol 9 (66) ◽  
pp. 38877-38881 ◽  
Author(s):  
Hangkong Yuan ◽  
Bright T. Kusema ◽  
Zhen Yan ◽  
Stéphane Streiff ◽  
Feng Shi
Keyword(s):  
Efficient Method ◽  
Bifunctional Catalyst ◽  
Reaction Process ◽  
Selective Synthesis ◽  
Two Stage ◽  
One Pot ◽  
Hydroxymethyl Furfural ◽  
Highly Efficient ◽  
Catalytic Amination

A simple and highly efficient method was developed for one pot transformation of 5-(hydroxymethyl)furfural (5-HMF) into 2,5-bis(aminomethyl)furan (BAF) over bifunctional Cu4Ni1Al4Ox catalyst using two-stage reaction process, affording the BAF in 85.9% yield.

scholarly journals Solvent-Free Green and Efficient One-Pot Synthesis of Dihydropyrano[3,2-c]chromene Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Shubha Jain ◽  
Deepika Rajguru ◽  
Balwant S. Keshwal ◽  
Aman D. Acharya
Keyword(s):  
Efficient Method ◽  
Present Method ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Reaction Conditions ◽  
One Pot ◽  
Highly Efficient ◽  
One Pot Synthesis

A rapid, clean, and highly efficient method for synthesis of dihydropyrano[3,2-c]chromene derivatives by one-pot, three-component condensation of aromatic aldehydes, malononitrile, and 4-hydroxycoumarin using DABCO as catalyst in solvent-free neat conditions is described. The present method has the advantages of mild reaction conditions, short reaction times, easy isolation of products, and excellent yields.

Nano zirconia catalysed one-pot synthesis of some novel substituted imidazoles under solvent-free conditions

RSC Advances ◽  
2015 ◽  
Vol 5 (36) ◽  
pp. 28163-28170 ◽  
Author(s):  
Shivam Bajpai ◽  
Sundaram Singh ◽  
Vandana Srivastava
Keyword(s):  
Multicomponent Reaction ◽  
Efficient Method ◽  
Ammonium Acetate ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
One Pot ◽  
Highly Efficient ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Isatin Derivatives

A highly efficient method for the synthesis of substituted imidazoles from a multicomponent reaction of isatin derivatives with ammonium acetate and aromatic aldehydes under solvent-free conditions has been established.

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