scholarly journals Solvent-Free Green and Efficient One-Pot Synthesis of Dihydropyrano[3,2-c]chromene Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Shubha Jain ◽  
Deepika Rajguru ◽  
Balwant S. Keshwal ◽  
Aman D. Acharya
Keyword(s):  
Efficient Method ◽  
Present Method ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Reaction Conditions ◽  
One Pot ◽  
Highly Efficient ◽  
One Pot Synthesis

A rapid, clean, and highly efficient method for synthesis of dihydropyrano[3,2-c]chromene derivatives by one-pot, three-component condensation of aromatic aldehydes, malononitrile, and 4-hydroxycoumarin using DABCO as catalyst in solvent-free neat conditions is described. The present method has the advantages of mild reaction conditions, short reaction times, easy isolation of products, and excellent yields.

Nano zirconia catalysed one-pot synthesis of some novel substituted imidazoles under solvent-free conditions

RSC Advances ◽  
2015 ◽  
Vol 5 (36) ◽  
pp. 28163-28170 ◽  
Author(s):  
Shivam Bajpai ◽  
Sundaram Singh ◽  
Vandana Srivastava
Keyword(s):  
Multicomponent Reaction ◽  
Efficient Method ◽  
Ammonium Acetate ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
One Pot ◽  
Highly Efficient ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Isatin Derivatives

A highly efficient method for the synthesis of substituted imidazoles from a multicomponent reaction of isatin derivatives with ammonium acetate and aromatic aldehydes under solvent-free conditions has been established.

Nanofibre Sepiolite Catalyzed Green and Rapid Synthesis of 2-Amino-4H-chromene Derivatives

2018 ◽  
Vol 71 (1) ◽  
pp. 32 ◽  
Author(s):  
Arezou Mohammadinezhad ◽  
Batool Akhlaghinia
Keyword(s):  
Column Chromatography ◽  
Present Method ◽  
Simple Procedure ◽  
Reaction Times ◽  
Significant Decline ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Rapid Synthesis ◽  
One Pot ◽  
Highly Efficient

Nanofibre sepiolite catalyzed the rapid, clean, and highly efficient synthesis of 2-amino-4H-chromene derivatives by a one-pot, three-component condensation of a series of aldehydes, various enolizable C–H bonds (such as dimedone, α-naphthol, resorcinol, and 4-hydroxy-2H-chromen-2-one), and malononitrile in a mixture of water/ethanol. The present method offers several advantages such as high to excellent yields, short reaction times, mild reaction conditions, simple procedure, use of inexpensive, non-toxic, and naturally available catalyst, easy isolation of the products, and no need for column chromatography. The catalyst could be easily separated from the reaction mixture and can be reused for many consecutive trials without a significant decline in its reactivity.

CuO Nanoparticles: A Mild and Efficient Reusable Catalyst for the One-Pot Synthesis of 4-amino-5-pyrimidinecarbonitriles under Aqueous Conditions

2012 ◽  
Vol 326-328 ◽  
pp. 372-376
Author(s):  
Seyed Javad Ahmadi ◽  
Sodeh Sadjadi ◽  
Morteza Hosseinpour
Keyword(s):  
Efficient Method ◽  
Reaction Times ◽  
Cuo Nanoparticles ◽  
Reusable Catalyst ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
The One ◽  
Aqueous Conditions

An efficient method for the synthesis of 4-amino-5-pyrimidinecarbonitriles by three-component reaction of malononitrile, aldehydes and N-unsubstituted amidines, under aqueous conditions, using CuO nanoparticles as catalyst is reported. The protocol offers advantages in terms of higher yields, short reaction times, and mild reaction conditions, with reusability of the catalyst.

Efficacious one-pot synthesis of 2-thiazolines and 2-oxazolines under solvent and metal-free conditions

2021 ◽  
Vol 08 ◽  
Author(s):  
Wassima Talbi ◽  
Jamil Kraiem ◽  
Yakdhane Kacem ◽  
Jérôme Marrot ◽  
Sylvain Marque
Keyword(s):  
High Temperature ◽  
Efficient Method ◽  
Reaction Times ◽  
Simple Approach ◽  
Solvent Free ◽  
Fast Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free

Background: 2-Oxazolines and 2-thiazolines are very important heterocycles due to their extensive applications in chemistry, biochemistry and pharmacology. Most of the precedent methods for preparing these heterocycles involve one or more drawbacks including harsh reaction conditions, long reaction times, low yields of products, high temperature and toxic solvents. Objective: A new and eco-efficient method developed for the preparation of 2-oxazolines and 2-thiazolines. Methods: condensation of amino alcohols with nitriles in a sealed tube under solvent-free and metal-free conditions. Results: Our procedure appears to be highly eco-efficient and promoted quantitative access to 2-oxazolines and 2-thiazolines under simple and minimum manipulation. Conclusion: This simple approach allows high conversion for different nitriles yielded from 78 to 99 % and easy isolation of the targeted products without further purification. To the best of our knowledge, our procedure is the best efficient and fast method reported to date, in terms of chemical yields, number of steps and atom economy.

scholarly journals “In Situ” Generated “HCl”: A Highly Efficient Catalyst for One-Pot Synthesis of 1H-Indazolo [1,2-b]phthalazine-1,6,11-triones and 1Hpyrazolo[1,2-b]phthalazine-5,10-diones under Solvent-Free Conditions

2017 ◽  
Vol 58 (2) ◽  
Author(s):  
Behrooz Maleki ◽  
Samaneh Sedigh Ashrafi
Keyword(s):  
Phthalic Anhydride ◽  
Solvent Free ◽  
Synthetic Route ◽  
Reaction Conditions ◽  
One Pot ◽  
Efficient Catalyst ◽  
Highly Efficient ◽  
One Pot Synthesis ◽  
Solvent Free Conditions

<p>The rapid and environmental synthetic route to produce 1<em>H</em>-indazolo[1,2-b] phthalazine-1,6,11-triones and 1<em>H</em>-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives have been developed <em>via</em> multicomponent and one-pot reactions of various aldehydes, cyclic or acyclic 1,3-diketones with: <em>i)</em> phthalhydrazide or <em>ii)</em> phthalic anhydride-hydrazinium hydroxide using wet 2,4,6-trichlorotriazine (TCT) as catalyst under solvent-free conditions. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.</p>

scholarly journals Solvent-Free Synthesis of 1,8-Dioxo-octahydroxanthenes and 14-Aryl-14H-dibenzo[a,j]xanthenes using Saccharin Sulfonic Acid as an Efficient and Green Catalyst

2012 ◽  
Vol 9 (4) ◽  
pp. 1854-1863 ◽  
Author(s):  
Abdolkarim Zare ◽  
Mohammad Mokhlesi ◽  
Alireza Hasaninejad ◽  
Tahereh Hekmat-Zadeh
Keyword(s):  
Sulfonic Acid ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Organic Transformations ◽  
One Pot ◽  
Green Catalyst ◽  
Highly Efficient ◽  
Solvent Free Conditions ◽  
Solvent Free Synthesis

Saccharin sulfonic acid (SaSA) is utilized as a highly efficient, green and inexpensive sulfonic acid-containing catalyst for the following one-pot multi-component organic transformations: (i) the condensation of dimedone (2 eq.) with aromatic aldehydes (1 eq.) leading to 1,8-dioxo-octahydroxanthenes, and (ii) the reaction of 2-naphthol (2 eq.) with arylaldehydes (1 eq.) leading to 14-aryl-14H-dibenzo[a,j]xanthenes. In these protocols, the title compounds are produced in high to excellent yields and in relatively short reaction times under solvent-free conditions.

Chlorosulfonic Acid Supported Piperidine-4-carboxylic Acid (PPCA) Functionalized Fe3O4 Nanoparticles (Fe3O4-PPCA): The Efficient, Green and Reusable Nanocatalyst for the Synthesis of Pyrazolyl Coumarin Derivatives under Solvent-Free Conditions

2019 ◽  
Vol 22 (2) ◽  
pp. 123-128
Author(s):  
Setareh Habibzadeh ◽  
Hassan Ghasemnejad-Bosra ◽  
Mina Haghdadi ◽  
Soheila Heydari-Parastar
Keyword(s):  
Carboxylic Acid ◽  
Fe3o4 Nanoparticles ◽  
High Efficiency ◽  
Reaction Times ◽  
Chlorosulfonic Acid ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Magnetic Nanocatalyst ◽  
One Pot ◽  
Solvent Free Conditions

Background: In this study, we developed a convenient methodology for the synthesis of coumarin linked to pyrazolines and pyrano [2,3-h] coumarins linked to 3-(1,5-diphenyl-4,5- dihydro-1H-pyrazol-3-yl)-chromen-2-one derivatives using Chlorosulfonic acid supported Piperidine-4-carboxylic acid (PPCA) functionalized Fe3O4 nanoparticles (Fe3O4-PPCA) catalyst. Materials and Methods:: Fe3O4-PPCA was investigated as an efficient and magnetically recoverable Nanocatalyst for the one-pot synthesis of substituted coumarins from the reaction of coumarin with a variety of aromatic aldehydes in high to excellent yield at room temperature under solvent-free conditions. The magnetic nanocatalyst can be easily recovered by applying an external magnet device and reused for at least 10 reaction runs without considerable loss of reactivity. Results and Conclusion: The advantages of this protocol are the use of commercially available materials, simple and an inexpensive procedure, easy separation, and an eco-friendly procedure, and it shows good reaction times, good to high yields, inexpensive and practicability procedure, and high efficiency.

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Visarapu Malathi ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

A highly efficient and green approach for the synthesis of pyrimido[4,5-b]quinolines using N,N-diethyl-N-sulfoethanaminium chloride

2021 ◽  
Vol 76 (2) ◽  
pp. 85-90
Author(s):  
Abdolkarim Zare ◽  
Manije Dianat
Keyword(s):  
Reaction Times ◽  
Solvent Free ◽  
One Pot ◽  
Catalyst Amount ◽  
Green Protocol ◽  
Highly Efficient ◽  
Green Approach ◽  
Solvent Free Conditions ◽  
The One ◽  
High Yields

Abstract A highly efficient and green protocol for the synthesis of pyrimido[4,5-b]quinolines has been described. The one-pot multicomponent reaction of dimedone with arylaldehydes and 6-amino-1,3-dimethyluracil in the presence of N,N-diethyl-N-sulfoethanaminium chloride ([Et3N–SO3H][Cl]) as an ionic liquid (IL) catalyst under solvent-free conditions afforded the mentioned compounds in high yields and short reaction times. Our protocol is superior to many of the reported protocols in terms of two or more of these factors: the reaction times, yields, conditions (solvent-free versus usage of organic solvents), temperature and catalyst amount.

Pt NPs@GO as a highly efficient and reusable catalyst for one-pot synthesis of acridinedione derivatives

RSC Advances ◽  
2015 ◽  
Vol 5 (61) ◽  
pp. 49295-49300 ◽  
Author(s):  
Handan Pamuk ◽  
Burak Aday ◽  
Fatih Şen ◽  
Muharrem Kaya
Keyword(s):  
Aromatic Aldehydes ◽  
Reusable Catalyst ◽  
One Pot ◽  
Highly Efficient ◽  
One Pot Synthesis ◽  
First Time

Pt NPs@GO has been used for the first time for synthesizing acridinedione from dimedone, aromatic aldehydes and various amines as a catalyst.

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