Synthesis of ketones via organolithium addition to acid chlorides using continuous flow chemistry

RSC Advances ◽  
2015 ◽  
Vol 5 (97) ◽  
pp. 79385-79390 ◽  
Author(s):  
Soo-Yeon Moon ◽  
Seo-Hee Jung ◽  
U. Bin Kim ◽  
Won-Suk Kim
Keyword(s):  
Efficient Method ◽  
Continuous Flow ◽  
Flow Chemistry ◽  
Acid Chlorides ◽  
Flow Conditions ◽  
Continuous Flow Chemistry

An efficient method for the synthesis of ketones using organolithium and acid chlorides under continuous flow conditions has been developed.

Recent Applications of Continuous Flow in Homogeneous Palladium Catalysis

Synthesis ◽  
2020 ◽  
Vol 52 (23) ◽  
pp. 3511-3529 ◽  
Author(s):  
Peter Koóš ◽  
Martin Markovič ◽  
Pavol Lopatka ◽  
Tibor Gracza
Keyword(s):  
Organic Synthesis ◽  
Continuous Flow ◽  
Palladium Catalysis ◽  
Flow Chemistry ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Flow Conditions ◽  
Cross Coupling Reactions ◽  
Continuous Flow Chemistry ◽  
Oxidative Transformations

Considerable advances have been made using continuous flow chemistry as an enabling tool in organic synthesis. Consequently, the number of articles reporting continuous flow methods has increased significantly in recent years. This review covers the progress achieved in homogeneous palladium catalysis using continuous flow conditions over the last five years, including C–C/C–N cross-coupling reactions, carbonylations and reductive/oxidative transformations.1 Introduction2 C–C Cross-Coupling Reactions3 C–N Coupling Reactions4 Carbonylation Reactions5 Miscellaneous Reactions6 Key to Schematic Symbols7 Conclusion

The influence of mixing on chain extension by photo-controlled/living radical polymerization under continuous-flow conditions

2019 ◽  
Vol 10 (35) ◽  
pp. 4879-4886 ◽  
Author(s):  
Fuyao Zhong ◽  
Yang Zhou ◽  
Mao Chen
Keyword(s):  
Radical Polymerization ◽  
Continuous Flow ◽  
Flow Chemistry ◽  
Polymer Synthesis ◽  
Living Radical Polymerization ◽  
Chain Extension ◽  
Flow Conditions ◽  
Continuous Flow Chemistry ◽  
Controlled Living Radical Polymerization

Continuous-flow chemistry holds powerful potential for polymer synthesis, and has attracted increasing attention in recent years.

A metal-free synthesis of 1,1-diphenylvinylsulfides with thiols via thioetherification under continuous-flow conditions

2020 ◽  
Vol 7 (12) ◽  
pp. 1490-1494 ◽  
Author(s):  
Jiawei Zhang ◽  
Erfei Wang ◽  
Yang Zhou ◽  
Lu Zhang ◽  
Mao Chen ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Chemistry ◽  
Flow Conditions ◽  
Aggregation Induced Emission ◽  
Metal Free ◽  
Mild Conditions ◽  
Continuous Flow Chemistry ◽  
Efficient Access

A continuous-flow chemistry facilitated protocol that allows efficient access to a novel aggregation-induced emission (AIE) luminogen 1,1-diphenylvinylsulfides utilizing thiols under metal-free and mild conditions.

scholarly journals Application of Reactor Engineering Concepts in Continuous Flow Chemistry: A Review

2021 ◽  
Author(s):  
Nicole Candice Neyt ◽  
Darren Lyall Riley
Keyword(s):  
Rapid Growth ◽  
Continuous Flow ◽  
Flow Chemistry ◽  
The Past ◽  
Continuous Flow Chemistry

The adoption of flow technology for the manufacture of chemical entities, and in particular pharmaceuticals, has seen rapid growth over the past two decades with the technology now blurring the...

scholarly journals Continuous-flow chemistry in chemical education

2017 ◽  
Vol 7 (3–4) ◽  
pp. 157-158 ◽  
Author(s):  
Daniel Blanco-Ania ◽  
Floris P. J. T. Rutjes
Keyword(s):  
Continuous Flow ◽  
Chemical Education ◽  
Flow Chemistry ◽  
Continuous Flow Chemistry

ChemInform Abstract: Continuous Flow Chemistry: A Discovery Tool for New Chemical Reactivity Patterns.

ChemInform ◽  
2014 ◽  
Vol 45 (44) ◽  
pp. no-no
Author(s):  
Jan Hartwig ◽  
Jan B. Metternich ◽  
Nikzad Nikbin ◽  
Andreas Kirschning ◽  
Steven V. Ley
Keyword(s):  
Continuous Flow ◽  
Chemical Reactivity ◽  
Flow Chemistry ◽  
Continuous Flow Chemistry

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

2022 ◽  
Author(s):  
Cloudius Sagandira ◽  
Sinazo Nqeketo ◽  
Kanysile Mhlana ◽  
Thembela Sonti ◽  
Paul Watts ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Continuous Flow ◽  
Industrial Revolution ◽  
Flow Chemistry ◽  
Active Pharmaceutical Ingredients ◽  
New Paradigm ◽  
Pharmaceutical Ingredients ◽  
Continuous Flow Chemistry

Continuous flow chemistry has opened a new paradigm in both the laboratory and pharmaceutical industry. This review details the recently reported literature on continuous multistep telescoped synthesis of active pharmaceutical...

scholarly journals The Eschenmoser coupling reaction under continuous-flow conditions

2011 ◽  
Vol 7 ◽  
pp. 1164-1172 ◽  
Author(s):  
Sukhdeep Singh ◽  
J Michael Köhler ◽  
Andreas Schober ◽  
G Alexander Groß
Keyword(s):  
Continuous Flow ◽  
Elevated Temperatures ◽  
Reaction Times ◽  
Coupling Reaction ◽  
Flow Chemistry ◽  
Flow Conditions ◽  
Reaction Conditions ◽  
Bond Forming ◽  
Carbon Carbon Bond ◽  
Reaction Proceeds

The Eschenmoser coupling is a useful carbon–carbon bond forming reaction which has been used in various different synthesis strategies. The reaction proceeds smoothly if S-alkylated ternary thioamides or thiolactames are used. In the case of S-alkylated secondary thioamides or thiolactames, the Eschenmoser coupling needs prolonged reaction times and elevated temperatures to deliver valuable yields. We have used a flow chemistry system to promote the Eschenmoser coupling under enhanced reaction conditions in order to convert the demanding precursors such as S-alkylated secondary thioamides and thiolactames in an efficient way. Under pressurized reaction conditions at about 220 °C, the desired Eschenmoser coupling products were obtained within 70 s residence time. The reaction kinetics was investigated and 15 examples of different building block combinations are given.

scholarly journals Scalable Synthesis of Norbornadienes via in situ Cracking of Dicyclopentadiene Using Continuous Flow Chemistry

2021 ◽  
Author(s):  
Jessica Orrego‐Hernández ◽  
Helen Hölzel ◽  
Maria Quant ◽  
Zhihang Wang ◽  
Kasper Moth‐Poulsen
Keyword(s):  
Continuous Flow ◽  
Flow Chemistry ◽  
Continuous Flow Chemistry ◽  
Scalable Synthesis
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