Preparation and application of bacteriophage-loaded chitosan microspheres for controlling Lactobacillus plantarum contamination in bioethanol fermentation

RSC Advances ◽  
2015 ◽  
Vol 5 (85) ◽  
pp. 69886-69893 ◽  
Author(s):  
Xianghua Lin ◽  
Pei Han ◽  
Shijun Dong ◽  
Hao Li
Keyword(s):  
Sustained Release ◽  
Lactobacillus Plantarum ◽  
Chitosan Microspheres ◽  
Action Time ◽  
Lactobacillus Plantarum Contamination

The bacteriophage-loaded chitosan microspheres can effectively controlL. plantarumcontamination in bioethanol fermentation. Moreover, sustained release of bacteriophage would enhance the effect of bacteriophage through prolonging the action time.

scholarly journals BIODEGRADABLE POLYMER: A NOVEL PHARMACEUTICAL CARRIER FOR SUSTAINED RELEASE OF METRONIDAZOLE

2017 ◽  
Vol 10 (10) ◽  
pp. 136
Author(s):  
Gayathri Hariharan ◽  
Priyanka Sinha
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Sustained Release ◽  
Biodegradable Polymer ◽  
Drug Loading ◽  
Cross Linking ◽  
Loading Capacity ◽  
Flow Properties ◽  
Chitosan Microspheres

Objective: To optimize and evaluate the formulation of metronidazole (MT)-loaded chitosan microspheres and to investigate the efficiency of biodegradable polymer in developing sustained release formulation of MT to prolong the action of drug.Methods: MT microspheres were prepared using emulsion cross-linking method. Polymer-drug compatibility study was done using Fourier transform infrared. Physical characteristics were evaluated by particle size,SEM, flow properties etc. In vitro studies for evaluating drug release for MT-loaded chitosan microspheres were done by dissolution study.Results: Particle size of the formulated microspheres was found to be within the range of 110-130 μm. Flow properties of F1-F7 such as angle of repose, bulk density, and tapped density were found to be within limits. Drug entrapment efficiency was found to be better for all the formulations within the range of 74.82-84.32% w/w. Drug loading capacity was found to be in the range of 56-83.2% w/v. In vitro drug release was found to be in the range of 81.32-96.23% w/v.Conclusion: In spite of all the above results, we conclude that F5 formulation was optimized depending on the data obtained from the drug loading capacity and percentage drug release studies. F5 formulation is formulated with drug-polymer ratio 1:2 with 1% of di octyl sodium sulfo succinate and 8 ml of glutaraldehyde as a cross-linking agent.

scholarly journals The efficacy of sustained-release chitosan microspheres containing recombinant human parathyroid hormone on MRONJ

2019 ◽  
Vol 33 ◽  
Author(s):  
Aysegul ERTEN TAYSI ◽  
Erdal CEVHER ◽  
Melike SESSEVMEZ ◽  
Vakur OLGAC ◽  
Nuri MERT TAYSI ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Sustained Release ◽  
Human Parathyroid Hormone ◽  
Chitosan Microspheres

Dual cross-linked chitosan microspheres formulated with spray-drying technique for the sustained release of levofloxacin

2019 ◽  
Vol 45 (4) ◽  
pp. 568-576 ◽  
Author(s):  
Jing Zhou ◽  
Yuanyuan Chen ◽  
Mengmeng Luo ◽  
Fen Deng ◽  
Sen Lin ◽  
...  
Keyword(s):  
Sustained Release ◽  
Spray Drying ◽  
Chitosan Microspheres

Preparation and evaluation of sustained release cross-linked chitosan microspheres containing phenobarbitone

1998 ◽  
Vol 15 (3) ◽  
pp. 373-382 ◽  
Author(s):  
A. A. Al-Helw ◽  
A. A. Al-Angary ◽  
G. M. Mahrous ◽  
M. M. Al-Dardari
Keyword(s):  
Sustained Release ◽  
Chitosan Microspheres ◽  
Preparation And Evaluation

Sonic Hedgehog Sustained Release from Sonic Hedgehog—Chitosan Microspheres and Its Biocompatibility Study

2016 ◽  
Vol 10 (1) ◽  
pp. 69-72
Author(s):  
Wenjing Yang ◽  
Jingxin Zhang ◽  
Xuewen Cui ◽  
Zhijian Zhang ◽  
Zhiyang Li
Keyword(s):  
Sustained Release ◽  
Sonic Hedgehog ◽  
Chitosan Microspheres ◽  
Biocompatibility Study

Comparison of chitosan microsphere versus O-carboxymethyl chitosan microsphere for drug delivery systems

2017 ◽  
Vol 32 (5) ◽  
pp. 469-486 ◽  
Author(s):  
Gang Zhou ◽  
Jing Zhang ◽  
Jun Tai ◽  
Qianyi Han ◽  
Lei Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Sustained Release ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Carboxymethyl Chitosan ◽  
Cross Linking ◽  
Chitosan Microspheres ◽  
Chitosan Microsphere

The development of controlled drug delivery systems for bone regeneration, especially microspheres, has become a research hotspot in recent years. Chitosan and its derivative O-carboxymethyl chitosan have been considered to be an effective way for controlled drug delivery due to their nontoxicity and biodegradability. Currently, most of the studies have researched on synthesizing and characterizing chitosan and O-carboxymethyl chitosan. However, few studies have focused on the differences between chitosan microspheres and O-carboxymethyl chitosan microspheres directly. In this study, chitosan and O-carboxymethyl chitosan microspheres were developed by water-in-oil emulsification cross-linking method using vanillin as the cross-linking agent, and then their physicochemical properties were evaluated by Fourier transform infrared spectroscopy, scanning electron microscopy, and in vitro release testing. The results showed that O-carboxymethyl chitosan was successfully modified by adding carboxymethyl group at the chitosan C6 position.The particle size of chitosan microspheres (50–90 µm) was significantly larger than that of O-carboxymethyl chitosan microspheres (10–50 µm), and the drug release profile of O-carboxymethyl chitosan microspheres showed larger initial burst release within the first day and sustained release at the fourth day, while chitosan microspheres showed sustained release at the seventh day. In addition, Cell Counting Kit-8 assay showed that MC3T3-E1 proliferated well and highly expressed the alkaline phosphatase marker protein on both chitosan and O-carboxymethyl chitosan microspheres. Overall, both chitosan and O-carboxymethyl chitosan microspheres showed good biocompatibility, and chitosan microspheres were superior to O-carboxymethyl chitosan microspheres. Moreover, the different drug release rates suggest that chitosan and O-carboxymethyl chitosan microspheres have the potential to be used for the repair of different bone defects.

Sustained release effects of berberine-loaded chitosan microspheres on in vitro chondrocyte culture

2017 ◽  
Vol 43 (10) ◽  
pp. 1703-1714 ◽  
Author(s):  
Yan Zhou ◽  
Shiqing Liu ◽  
Jianghua Ming ◽  
Yaming Li ◽  
Ming Deng ◽  
...  
Keyword(s):  
Sustained Release ◽  
Chitosan Microspheres ◽  
Chondrocyte Culture
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