Sonic Hedgehog Sustained Release from Sonic Hedgehog—Chitosan Microspheres and Its Biocompatibility Study

2016 ◽  
Vol 10 (1) ◽  
pp. 69-72
Author(s):  
Wenjing Yang ◽  
Jingxin Zhang ◽  
Xuewen Cui ◽  
Zhijian Zhang ◽  
Zhiyang Li
Keyword(s):  
Sustained Release ◽  
Sonic Hedgehog ◽  
Chitosan Microspheres ◽  
Biocompatibility Study

scholarly journals BIODEGRADABLE POLYMER: A NOVEL PHARMACEUTICAL CARRIER FOR SUSTAINED RELEASE OF METRONIDAZOLE

2017 ◽  
Vol 10 (10) ◽  
pp. 136
Author(s):  
Gayathri Hariharan ◽  
Priyanka Sinha
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Sustained Release ◽  
Biodegradable Polymer ◽  
Drug Loading ◽  
Cross Linking ◽  
Loading Capacity ◽  
Flow Properties ◽  
Chitosan Microspheres

Objective: To optimize and evaluate the formulation of metronidazole (MT)-loaded chitosan microspheres and to investigate the efficiency of biodegradable polymer in developing sustained release formulation of MT to prolong the action of drug.Methods: MT microspheres were prepared using emulsion cross-linking method. Polymer-drug compatibility study was done using Fourier transform infrared. Physical characteristics were evaluated by particle size,SEM, flow properties etc. In vitro studies for evaluating drug release for MT-loaded chitosan microspheres were done by dissolution study.Results: Particle size of the formulated microspheres was found to be within the range of 110-130 μm. Flow properties of F1-F7 such as angle of repose, bulk density, and tapped density were found to be within limits. Drug entrapment efficiency was found to be better for all the formulations within the range of 74.82-84.32% w/w. Drug loading capacity was found to be in the range of 56-83.2% w/v. In vitro drug release was found to be in the range of 81.32-96.23% w/v.Conclusion: In spite of all the above results, we conclude that F5 formulation was optimized depending on the data obtained from the drug loading capacity and percentage drug release studies. F5 formulation is formulated with drug-polymer ratio 1:2 with 1% of di octyl sodium sulfo succinate and 8 ml of glutaraldehyde as a cross-linking agent.

scholarly journals The efficacy of sustained-release chitosan microspheres containing recombinant human parathyroid hormone on MRONJ

2019 ◽  
Vol 33 ◽  
Author(s):  
Aysegul ERTEN TAYSI ◽  
Erdal CEVHER ◽  
Melike SESSEVMEZ ◽  
Vakur OLGAC ◽  
Nuri MERT TAYSI ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Sustained Release ◽  
Human Parathyroid Hormone ◽  
Chitosan Microspheres

Dual cross-linked chitosan microspheres formulated with spray-drying technique for the sustained release of levofloxacin

2019 ◽  
Vol 45 (4) ◽  
pp. 568-576 ◽  
Author(s):  
Jing Zhou ◽  
Yuanyuan Chen ◽  
Mengmeng Luo ◽  
Fen Deng ◽  
Sen Lin ◽  
...  
Keyword(s):  
Sustained Release ◽  
Spray Drying ◽  
Chitosan Microspheres

Preparation and evaluation of sustained release cross-linked chitosan microspheres containing phenobarbitone

1998 ◽  
Vol 15 (3) ◽  
pp. 373-382 ◽  
Author(s):  
A. A. Al-Helw ◽  
A. A. Al-Angary ◽  
G. M. Mahrous ◽  
M. M. Al-Dardari
Keyword(s):  
Sustained Release ◽  
Chitosan Microspheres ◽  
Preparation And Evaluation

Comparison of chitosan microsphere versus O-carboxymethyl chitosan microsphere for drug delivery systems

2017 ◽  
Vol 32 (5) ◽  
pp. 469-486 ◽  
Author(s):  
Gang Zhou ◽  
Jing Zhang ◽  
Jun Tai ◽  
Qianyi Han ◽  
Lei Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Sustained Release ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Carboxymethyl Chitosan ◽  
Cross Linking ◽  
Chitosan Microspheres ◽  
Chitosan Microsphere

The development of controlled drug delivery systems for bone regeneration, especially microspheres, has become a research hotspot in recent years. Chitosan and its derivative O-carboxymethyl chitosan have been considered to be an effective way for controlled drug delivery due to their nontoxicity and biodegradability. Currently, most of the studies have researched on synthesizing and characterizing chitosan and O-carboxymethyl chitosan. However, few studies have focused on the differences between chitosan microspheres and O-carboxymethyl chitosan microspheres directly. In this study, chitosan and O-carboxymethyl chitosan microspheres were developed by water-in-oil emulsification cross-linking method using vanillin as the cross-linking agent, and then their physicochemical properties were evaluated by Fourier transform infrared spectroscopy, scanning electron microscopy, and in vitro release testing. The results showed that O-carboxymethyl chitosan was successfully modified by adding carboxymethyl group at the chitosan C6 position.The particle size of chitosan microspheres (50–90 µm) was significantly larger than that of O-carboxymethyl chitosan microspheres (10–50 µm), and the drug release profile of O-carboxymethyl chitosan microspheres showed larger initial burst release within the first day and sustained release at the fourth day, while chitosan microspheres showed sustained release at the seventh day. In addition, Cell Counting Kit-8 assay showed that MC3T3-E1 proliferated well and highly expressed the alkaline phosphatase marker protein on both chitosan and O-carboxymethyl chitosan microspheres. Overall, both chitosan and O-carboxymethyl chitosan microspheres showed good biocompatibility, and chitosan microspheres were superior to O-carboxymethyl chitosan microspheres. Moreover, the different drug release rates suggest that chitosan and O-carboxymethyl chitosan microspheres have the potential to be used for the repair of different bone defects.

Sustained release effects of berberine-loaded chitosan microspheres on in vitro chondrocyte culture

2017 ◽  
Vol 43 (10) ◽  
pp. 1703-1714 ◽  
Author(s):  
Yan Zhou ◽  
Shiqing Liu ◽  
Jianghua Ming ◽  
Yaming Li ◽  
Ming Deng ◽  
...  
Keyword(s):  
Sustained Release ◽  
Chitosan Microspheres ◽  
Chondrocyte Culture

Preparation and Characterization of Genipin-Crosslinked Chitosan Microspheres for the Sustained Release of Salidroside

2015 ◽  
Vol 11 (3) ◽  
pp. 323-333 ◽  
Author(s):  
Mei Luo ◽  
Hailong Peng ◽  
Zhonghua Deng ◽  
Zhonghua Yin ◽  
Qiang Zhao ◽  
...  
Keyword(s):  
Sustained Release ◽  
Functional Foods ◽  
Anomalous Behavior ◽  
Fickian Diffusion ◽  
Release Behavior ◽  
Chitosan Microspheres ◽  
Naturally Occurring ◽  
The Stability

Abstract Chitosan microspheres (CsMs) that encapsulate salidroside (Sal) were prepared by the emulsion crosslinking method with naturally occurring genipin (Gp) and then examined for their in vitro release. Sal-loaded CsMs (Sal-CsMs) showed nearly spherical and smooth surfaces with internal voids. The particle size of Sal-CsMs ranged within 0.56–5.01 μm, and their encapsulation efficiency and loading capacity were beyond 77.58% and 23.29%, respectively. The stability of Sal improved after entrapment into the CsMs. The release rate of Sal from CsMs was initially rapid, followed by sustained release. The release behavior depended on the pH of the release medium. The main release mechanisms underlying the release procedure were anomalous behavior and Fickian diffusion. These results indicated that CsMs with a novel crosslinker of Gp was a potential carrier system for producing functional foods containing Sal.

Sustained release optimized formulation of anastrozole-loaded chitosan microspheres: in vitro and in vivo evaluation

2011 ◽  
Vol 22 (4) ◽  
pp. 865-878 ◽  
Author(s):  
Gopal V. Shavi ◽  
Usha Y. Nayak ◽  
M. Sreenivasa Reddy ◽  
A. Karthik ◽  
Praful B. Deshpande ◽  
...  
Keyword(s):  
Sustained Release ◽  
In Vivo Evaluation ◽  
Chitosan Microspheres

scholarly journals FORMULATION AND IN-VITRO-IN-VIVO EVALUATION OF ALGINATE-CHITOSAN MICROSPHERES OF GLIPIZIDE BY IONIC GELATION METHOD

2017 ◽  
Vol 10 (7) ◽  
pp. 385 ◽  
Author(s):  
Maya Sharma ◽  
Choudhury Pk ◽  
Suresh Kumar Dev
Keyword(s):  
Sustained Release ◽  
Dosage Form ◽  
Oral Dosage ◽  
Ionic Gelation ◽  
In Vivo Evaluation ◽  
Chitosan Microspheres ◽  
Model Drug ◽  
Effective Use

Objective: The present work is aimed to formulate and evaluate alginate-chitosan microspheres of glipizide for the effective use in the treatment of diabetes.Methods: Sustained release microspheres were prepared by gentle mixing of polymers in water phase with drug by agitation. The polymers used for preparation were sodium alginate and chitosan, which was extruded into 5% calcium chloride solution to produce microspheres by ionic gelation method.Results: Single unit dosage form of Glipizide causes gastric irritation. To convert it in to the multiple unit dosage form will release the drug evenly throughout the stomach which suppresses the irritation. The aim of study towards formulation and evaluation of alginate-chitosan microspheres, which can provide sustained release of the model drug. It shows better in-vitro and in-vivo activity than conventional dosage forms. The work also aims to study various parameters affecting the behavior of microspheres in oral dosage form. Conclusion:  Drugs that are simply absorbed from the gastrointestinal tract (GIT) and having a short half life are eliminated rapidly from the blood flow. To avoid this trouble, the oral sustained release (SR) has been developed as these will release the drug slowly in to the GIT and maintain a stable drug concentration in the serum for a longer period of time.

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