SERS-active silver nanoparticle trimers for sub-attomolar detection of alpha fetoprotein

RSC Advances ◽  
2015 ◽  
Vol 5 (90) ◽  
pp. 73395-73398 ◽  
Author(s):  
Xiaoling Wu ◽  
Pan Fu ◽  
Wei Ma ◽  
Liguang Xu ◽  
Hua Kuang ◽  
...  
Keyword(s):  
Silver Nanoparticle ◽  
Cancer Biomarker ◽  
Alpha Fetoprotein ◽  
First Time

SERS-active silver nanoparticle trimers were assembled in this study for the first time, through the aptamer of a cancer biomarker, alpha fetoprotein (AFP).

Adriamycin coated silica microsphere as labels for cancer biomarker alpha-fetoprotein detection

2021 ◽  
Author(s):  
Yuzhong Zhang ◽  
Wenwen Meng ◽  
Mengrao Li
Keyword(s):  
Cancer Biomarker ◽  
Alpha Fetoprotein ◽  
Silica Microspheres ◽  
Silica Microsphere

Adriamycin (ADM) coated silica microspheres as a labels for a sensitive cancer biomarker Alpha-fetoprotein (AFP) detection was reported. Silica microspheres (SiO2 MS) were employed as carrier for the immobilization of...

The small silver nanoparticle-assisted homogeneous sensing of thiocyanate ions with an ultra-wide window based on surface-enhanced Raman-extinction spectroscopy

2021 ◽  
Author(s):  
Xiang-Ru Bai ◽  
Lei Zhang ◽  
Jia-Qiang Ren ◽  
Ai-Guo Shen ◽  
Ji-Ming Hu
Keyword(s):  
Silver Nanoparticle ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Detection Window ◽  
First Time

For the first time, we present an original sensing strategy with an ultra-wide detection window from 17 nM to 20 mM to detect SCN− ions.

Label-free, ITO-based immunosensor for the detection of a cancer biomarker: Receptor for Activated C Kinase 1

The Analyst ◽  
2016 ◽  
Vol 141 (19) ◽  
pp. 5618-5626 ◽  
Author(s):  
E. B. Bahadır ◽  
M. K. Sezgintürk
Keyword(s):  
Cancer Biomarker ◽  
Label Free ◽  
First Time

A new, quite sensitive disposable immunosensor, based on the anti-RACK1 antibody, was developed for the determination of Receptor for Activated C Kinase 1 (RACK1) for the first time.

A Novel Amperometric Immunosensor for Detection of Alpha-Fetoprotein Based on Magnetic and Electroactive Nanoprobes

2011 ◽  
Vol 345 ◽  
pp. 411-416
Author(s):  
Ling Hua Meng ◽  
Yu Ting Cao ◽  
Fu Tao Hu ◽  
Tian Hua Li ◽  
Ning Gan
Keyword(s):  
Signal To Noise Ratio ◽  
Three Dimensional ◽  
Alpha Fetoprotein ◽  
Serum Samples ◽  
Electron Mediator ◽  
Experimental Conditions ◽  
Au Nps ◽  
Transmission Electron ◽  
Walled Carbon Nanotubes ◽  
First Time

A novel three-dimensional, magnetic and electroactive nanoprobes were constructed for the first time. Using hemin (TPP) as electron mediator, mutli-walled carbon nanotubes with carboxyl groups (MCNTs) as supporter, a novel (MCNTs-TPP-Fe3O4)magnetic nanocomposites were first prepared. Then using alpha-fetoprotein (AFP) as model system, gold nanoparticles (Au NPs) as immobilizing matrix, the AFP/anti-AFP/Au NPs/ MCNTs-TPP-Fe3O4nanoprobes were prepared and then dropped on the surface of screen-printed working electrode (SPCE) to construct a new amperometric immunosensors for detecting biomakers. The microstructure of different nanoparticles were observed by transmission electron microscopy (TEM) andX-ray fluorescence spectrometery (XRFS). Under optimal experimental conditions, the logarithm of response signal was proportional to the logarithm of AFP concentration from 0.1 to 200 ng/mL, with a correlation coefficient of 0.998. The detection limit was 0.04 ng/mL at a signal-to-noise ratio of 3. The proposed method offered a platform for fast, sensitive and simultaneous determination for serum samples.

Familial synchronous bilateral teratoid Wilms tumor with elevated alpha-fetoprotein level

2012 ◽  
Vol 98 (6) ◽  
pp. e179-e182 ◽  
Author(s):  
Arzu Okur ◽  
Faruk Guclu Pinarli ◽  
Ceyda Karadeniz ◽  
Aylar Poyraz ◽  
Kibriya Fidan ◽  
...  
Keyword(s):  
Tumor Volume ◽  
Age Of Onset ◽  
Wilms Tumor ◽  
Alpha Fetoprotein ◽  
Rare Entity ◽  
Rare Type ◽  
Specific Tumor ◽  
Serum Alpha Fetoprotein ◽  
First Time ◽  
Specific Tumor Marker

Familial Wilms tumor is a rare entity that accounts for only 1–2% of all Wilms tumor cases, with an earlier age of onset and an increased frequency of bilateral tumors. Teratoid Wilms tumor is a variant of nephroblastoma with a predominance of heterologous tissues comprising more than 50% of the tumor volume. Wilms tumor does not usually secrete any specific tumor marker and all teratoid Wilms tumor cases previously reported were sporadic non-secreting neoplasms. Here we describe an infant with familial synchronous bilateral teratoid Wilms tumor whose serum alpha-fetoprotein level was elevated. To our knowledge, this extremely rare type of case is reported for the first time in the literature.

scholarly journals Atmospheric Pressure Microplasma for Antibacterial Silver Nanoparticle/Chitosan Nanocomposites With Tailored Properties

2019 ◽  
Author(s):  
Daye Sun ◽  
Jonathan Turner ◽  
Nan Jiang ◽  
Songsong Zhu ◽  
Li Zhang ◽  
...  
Keyword(s):  
Silver Nanoparticle ◽  
Atmospheric Pressure ◽  
Room Temperature ◽  
Polymer Network ◽  
Antibacterial Properties ◽  
Bacterial Strains ◽  
E Coli ◽  
Modified Chitosan ◽  
First Time

<p>Room temperature atmospheric pressure microplasma (APM) was deployed for the first time for the in situ synthesis of anti-bacterial silver nanoparticle / chitosan (AgNP/CS) nanocomposites. The plasma induced liquid chemistry plays a role in the in situ formation of AgNP, the size distribution of which depends on the silver salt precursor concentration. The microplasma process has also simultaneously tailored the physical properties of the composites, rendering more crosslinked chitosan polymer network with shorter molecular chains. The formation of AgNP within the <i>in situ</i> modified chitosan has led to nanocomposites with overall improved mechanical properties and better stability in simulated body fluid. Our plasma synthesized AgNP/CS nanocomposites also demonstrate effective antibacterial properties against <i>E. Coli</i> and <i>S. Aureus</i> bacterial strains, showing their promise in potential antimicrobial applications.</p>

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