scholarly journals Nanotopological-tailored calcium phosphate cements for the odontogenic stimulation of human dental pulp stem cells through integrin signaling

RSC Advances ◽  
2015 ◽  
Vol 5 (78) ◽  
pp. 63363-63371 ◽  
Author(s):  
So-Youn Lee ◽  
Hyung-Mun Yun ◽  
Roman A. Perez ◽  
Sara Gallinetti ◽  
Maria-Pau Ginebra ◽  
...  
Keyword(s):  
Stem Cells ◽  
Calcium Phosphate ◽  
Dental Pulp ◽  
Integrin Signaling ◽  
Dental Pulp Cells ◽  
Human Dental Pulp Cells ◽  
Calcium Phosphate Cements ◽  
Human Dental Pulp ◽  
Pulp Cells ◽  
Stimulation Of

Nanotopological-tailored calcium phosphate cements stimulate odontogenesis of human dental pulp cells through integrin-mediated signaling pathways.

Effect of Calcium Phosphate Cements on Growth and Odontoblastic Differentiation in Human Dental Pulp Cells

2010 ◽  
Vol 36 (9) ◽  
pp. 1537-1542 ◽  
Author(s):  
Sun-Kyung Lee ◽  
Sang-Kwang Lee ◽  
Sang-Im Lee ◽  
Jeong-Hui Park ◽  
Jun-Hyeog Jang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Dental Pulp ◽  
Dental Pulp Cells ◽  
Human Dental Pulp Cells ◽  
Calcium Phosphate Cements ◽  
Odontoblastic Differentiation ◽  
Human Dental Pulp ◽  
Pulp Cells

Odontogenic stimulation of human dental pulp cells with bioactive nanocomposite fiber

2014 ◽  
Vol 29 (6) ◽  
pp. 854-866 ◽  
Author(s):  
Ga-Hyun Kim ◽  
Yong-Duk Park ◽  
So-Youn Lee ◽  
Ahmed El-Fiqi ◽  
Jung-Ju Kim ◽  
...  
Keyword(s):  
Dental Pulp ◽  
Dental Pulp Cells ◽  
Human Dental Pulp Cells ◽  
Nanocomposite Fiber ◽  
Human Dental Pulp ◽  
Pulp Cells ◽  
Stimulation Of

Genotoxicity assessment of biphasic calcium phosphate of modified porosity on human dental pulp cells using Ames and Comet assays

2018 ◽  
Vol 47 ◽  
pp. 207-212 ◽  
Author(s):  
Nur Fathin Alia Che Wahab ◽  
Thirumulu Ponnuraj Kannan ◽  
Zuliani Mahmood ◽  
Ismail Ab. Rahman ◽  
Hanafi Ismail
Keyword(s):  
Calcium Phosphate ◽  
Dental Pulp ◽  
Biphasic Calcium Phosphate ◽  
Dental Pulp Cells ◽  
Human Dental Pulp Cells ◽  
Human Dental Pulp ◽  
Pulp Cells

Effect of different calcium phosphate scaffold ratios on odontogenic differentiation of human dental pulp cells

2015 ◽  
Vol 49 ◽  
pp. 225-233 ◽  
Author(s):  
Sarah Talib AbdulQader ◽  
Thirumulu Ponnuraj Kannan ◽  
Ismail Ab Rahman ◽  
Hanafi Ismail ◽  
Zuliani Mahmood
Keyword(s):  
Calcium Phosphate ◽  
Dental Pulp ◽  
Dental Pulp Cells ◽  
Human Dental Pulp Cells ◽  
Odontogenic Differentiation ◽  
Human Dental Pulp ◽  
Pulp Cells

scholarly journals Novel Calcium Phosphate Cement with Metformin-Loaded Chitosan for Odontogenic Differentiation of Human Dental Pulp Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Wei Qin ◽  
Jia-Yao Chen ◽  
Jia Guo ◽  
Tao Ma ◽  
Michael D. Weir ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Dental Pulp ◽  
Dental Pulp Cells ◽  
Human Dental Pulp Cells ◽  
Odontogenic Differentiation ◽  
Human Dental Pulp ◽  
Pulp Cells ◽  
Chitosan Composite ◽  
Dentin Regeneration

Metformin is an old and widely accepted first-line drug for treating type 2 diabetes. Our previous studies demonstrate that metformin can stimulate the osteo/odontogenic differentiation of human-induced pluripotent stem cell-derived mesenchymal stem cells and human dental pulp cells (DPCs). Due to the rapid dilution of metformin from the defect area, the aim of this study was to develop a drug delivery system with controlled release of metformin to promote cell viability and odontogenic differentiation of DPCs favoring dentin regeneration. Calcium phosphate cement (CPC) containing chitosan and metformin as a scaffold was synthesized. DPCs were seeded onto the scaffold, and the viability and proliferation were evaluated at several time points. For osteogenic differentiation analysis, alkaline phosphatase (ALP) activity was tested, cells were stained with Alizarin Red, and the expression of odontogenic markers was evaluated by real-time polymerase chain reaction. DPCs remained viable and attached well to the CPC-chitosan composite scaffold. Moreover, the addition of metformin to the CPC-chitosan composite did not adversely affect cell proliferation, compared to that of CPC control. Our data further revealed that the novel CPC-chitosan-metformin composite enhanced the odontogenic differentiation of DPCs, as evidenced by higher ALP activity, elevated expression of odontoblastic markers, and strong mineral deposition. These results suggest that the new CPC-chitosan-metformin composite is a highly promising scaffold with the potential for tissue engineering applications including dentin regeneration.

Stimulation of Interleukin-1β-Independent Interleukin-6 Production in Human Dental Pulp Cells by Lipopolysaccharide

1996 ◽  
Vol 59 (2) ◽  
pp. 138-143 ◽  
Author(s):  
Shiki Hosoya ◽  
Kiyoshi Matsushima ◽  
Emi Ohbayashi ◽  
Muneyoshi Yamazaki ◽  
Yasuko Shibata ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Dental Pulp ◽  
Interleukin 1Β ◽  
Dental Pulp Cells ◽  
Human Dental Pulp Cells ◽  
Human Dental Pulp ◽  
Pulp Cells ◽  
Stimulation Of
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