Ligand-conjugated pH-sensitive polymeric micelles for the targeted delivery of gefitinib in lung cancers

RSC Advances ◽  
2015 ◽  
Vol 5 (89) ◽  
pp. 73184-73193 ◽  
Author(s):  
Shi-Jiang Wang ◽  
Zhi-Jun Huo ◽  
Kai Liu ◽  
Ning Yu ◽  
Yan Ma ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Ph Sensitive ◽  
Lung Cancers ◽  
Effective Delivery

The aim of the present study was to investigate the tumor targeting potential of a mannose-conjugated pH-sensitive nanosystem for the effective delivery of gefitinib (Gnb) to lung cancers.

Development of cholate conjugated hybrid polymeric micelles for FXR receptor mediated effective site-specific delivery of paclitaxel

2018 ◽  
Vol 42 (20) ◽  
pp. 17021-17032 ◽  
Author(s):  
Sivaraj Mehnath ◽  
Mukherjee Arjama ◽  
Mariappan Rajan ◽  
Murugaraj Jeyaraj
Keyword(s):  
Cholic Acid ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Polymeric Micelle ◽  
Site Specific ◽  
Effective Delivery ◽  
Effective Site ◽  
Micelle System

The aim of the present study was to explore the tumor targeting potential of a cholic acid (CA) conjugated polymeric micelle system for the effective delivery of paclitaxel (PTX).

pH-sensitive polymeric micelles for targeted delivery to inflamed joints

2017 ◽  
Vol 246 ◽  
pp. 133-141 ◽  
Author(s):  
Chunhong Li ◽  
Hanmei Li ◽  
Qin Wang ◽  
Meiling Zhou ◽  
Man Li ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Polymeric Micelles ◽  
Ph Sensitive

scholarly journals Spermine modified polymeric micelles with pH-sensitive drug release for targeted and enhanced antitumor therapy

RSC Advances ◽  
2019 ◽  
Vol 9 (20) ◽  
pp. 11026-11037 ◽  
Author(s):  
Yang Chen ◽  
Cejun Yang ◽  
Juan Mao ◽  
Haigang Li ◽  
Jinsong Ding ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Ph Sensitive ◽  
Antitumor Therapy ◽  
Anti Cancer ◽  
Targeting Delivery

Tumor targeting delivery of SPM functionalized micelles via PTS binding and their endocytosis and pH-triggered endo/lysosome drug release for anti-cancer therapy.

scholarly journals Tumor-Targeting Peptides Search Strategy for the Delivery of Therapeutic and Diagnostic Molecules to Tumor Cells

2020 ◽  
Vol 22 (1) ◽  
pp. 314
Author(s):  
Maria D. Dmitrieva ◽  
Anna A. Voitova ◽  
Maya A. Dymova ◽  
Vladimir A. Richter ◽  
Elena V. Kuligina
Keyword(s):  
Phage Display ◽  
Cell Sorting ◽  
Targeted Delivery ◽  
Tumor Targeting ◽  
Search Strategy ◽  
Tumor Therapy ◽  
Therapeutic Agents ◽  
Phage Libraries

Background: The combination of the unique properties of cancer cells makes it possible to find specific ligands that interact directly with the tumor, and to conduct targeted tumor therapy. Phage display is one of the most common methods for searching for specific ligands. Bacteriophages display peptides, and the peptides themselves can be used as targeting molecules for the delivery of diagnostic and therapeutic agents. Phage display can be performed both in vitro and in vivo. Moreover, it is possible to carry out the phage display on cells pre-enriched for a certain tumor marker, for example, CD44 and CD133. Methods: For this work we used several methods, such as phage display, sequencing, cell sorting, immunocytochemistry, phage titration. Results: We performed phage display using different screening systems (in vitro and in vivo), different phage libraries (Ph.D-7, Ph.D-12, Ph.D-C7C) on CD44+/CD133+ and without enrichment U-87 MG cells. The binding efficiency of bacteriophages displayed tumor-targeting peptides on U-87 MG cells was compared in vitro. We also conducted a comparative analysis in vivo of the specificity of the accumulation of selected bacteriophages in the tumor and in the control organs (liver, brain, kidney and lungs). Conclusions: The screening in vivo of linear phage peptide libraries for glioblastoma was the most effective strategy for obtaining tumor-targeting peptides providing targeted delivery of diagnostic and therapeutic agents to glioblastoma.

scholarly journals Tumor targeting of a cell penetrating peptide by fusing with a pH-sensitive histidine-glutamate co-oligopeptide

Biomaterials ◽  
2014 ◽  
Vol 35 (13) ◽  
pp. 4082-4087 ◽  
Author(s):  
Likun Fei ◽  
Li-Peng Yap ◽  
Peter S. Conti ◽  
Wei-Chiang Shen ◽  
Jennica L. Zaro
Keyword(s):  
Tumor Targeting ◽  
Ph Sensitive ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell

scholarly journals New Protein Vector ApE1 for Targeted Delivery of Anticancer Drugs

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
N. V. Pozdniakova ◽  
N. V. Gorokhovets ◽  
N. V. Gukasova ◽  
A. V. Bereznikova ◽  
E. S. Severin
Keyword(s):  
Targeted Delivery ◽  
Tumor Targeting ◽  
Drug Loading ◽  
Bacterial Biomass ◽  
Receptor Binding Domain ◽  
Producer Strain ◽  
E Coli ◽  
Cytotoxic Compound ◽  
Soluble State ◽  
New Protein

A new chimeric geneApE1encoding the receptor-binding domain of the humanalpha-fetoprotein fused to a sequence of 22 glutamic acid residues was constructed. A new bacterial producer strainE. coliSHExT7 ApE1 was selected for ApE1 production in a soluble state. A simplified method was developed to purify ApE1 from bacterial biomass. It was shown that the new vector protein selectively interacts with AFP receptors on the tumor cell surface and can be efficiently accumulated in tumor cells. In addition, ApE1 was shown to be stable in storage and during its chemical modification. An increased number of carboxyl groups in the molecule allows the production of cytotoxic compound conjugates with higher drug-loading capacity and enhanced tumor targeting potential.

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