scholarly journals Solid phase synthesis of functionalized indazoles using triazenes – scope and limitations

RSC Advances ◽  
2015 ◽  
Vol 5 (80) ◽  
pp. 65540-65545 ◽  
Author(s):  
Ana Maria Garcia ◽  
Nicole Jung ◽  
Carmen Gil ◽  
Martin Nieger ◽  
Stefan Bräse
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Supports ◽  
Phase Synthesis ◽  
Modular Synthesis

In this study, we present a modular synthesis of highly substituted indazoles via a strategy on solid supports.

Combinatorial Solid-Phase Synthesis of 6-Aryl-1,3,5-triazines via Suzuki Coupling

2011 ◽  
Vol 64 (5) ◽  
pp. 540 ◽  
Author(s):  
Jae Wook Lee ◽  
Hyung-Ho Ha ◽  
Marc Vendrell ◽  
Jacqueline T. Bork ◽  
Young-Tae Chang
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cross Coupling ◽  
Structural Diversity ◽  
Suzuki Coupling ◽  
Purification Step ◽  
Solid Supports ◽  
Phase Synthesis ◽  
Triazine Derivatives ◽  
Polymer Supported

A synthetic methodology to prepare collections of trisubstituted aryl 1,3,5-triazines with broad structural diversity via Suzuki coupling has been developed. We first optimized the combinatorial derivatization of the triazine core using Suzuki cross-coupling. Second, in order to further expand the methodology for the preparation of negatively charged triazines, we adapted this approach to polymer-supported amino acids and prepared aryl triazines with different charge distribution. With a collection of 160 aryl triazine derivatives in good purities and without any purification step, we proved the viability of this orthogonal scheme for the preparation of triazine libraries using amine/amino acid-captured solid supports and Suzuki cross-coupling.

scholarly journals Novel Non-PEG Derived Polyethers as Solid Supports. 2. Solid-Phase Synthesis Studies

2007 ◽  
Vol 9 (6) ◽  
pp. 1012-1027 ◽  
Author(s):  
Gabriel Cavalli ◽  
Andrew G. Shooter ◽  
David A. Pears ◽  
Donald A. Wellings ◽  
Saeed Gulzar ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Supports ◽  
Phase Synthesis

scholarly journals Peptoids and polyamines going sweet: Modular synthesis of glycosylated peptoids and polyamines using click chemistry

2013 ◽  
Vol 9 ◽  
pp. 56-63 ◽  
Author(s):  
Daniel Fürniss ◽  
Timo Mack ◽  
Frank Hahn ◽  
Sidonie B L Vollrath ◽  
Katarzyna Koroniak ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Click Chemistry ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Building Blocks ◽  
Bioactive Molecules ◽  
Phase Synthesis ◽  
Modular Synthesis ◽  
Wide Range ◽  
Up Scaling

Sugar moieties are present in a wide range of bioactive molecules. Thus, having versatile and fast methods for the decoration of biomimetic molecules with sugars is of fundamental importance. The glycosylation of peptoids and polyamines as examples of such biomimetic molecules is reported here. The method uses Cu-catalyzed azide alkyne cycloaddition to promote the reaction of azidosugars with either polyamines or peptoids. In addition, functionalized nucleic acids were attached to polyamines via the same route. Based on a modular solid-phase synthesis of peralkynylated peptoids with up to six alkyne groups, the latter were modified with azidosugar building blocks by using copper-catalyzed azide alkyne cycloadditions. In addition, the up-scaling of some particular azide-modified sugars is described.

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