scholarly journals Novel Non-PEG Derived Polyethers as Solid Supports. 2. Solid-Phase Synthesis Studies

2007 ◽  
Vol 9 (6) ◽  
pp. 1012-1027 ◽  
Author(s):  
Gabriel Cavalli ◽  
Andrew G. Shooter ◽  
David A. Pears ◽  
Donald A. Wellings ◽  
Saeed Gulzar ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Supports ◽  
Phase Synthesis

Combinatorial Solid-Phase Synthesis of 6-Aryl-1,3,5-triazines via Suzuki Coupling

2011 ◽  
Vol 64 (5) ◽  
pp. 540 ◽  
Author(s):  
Jae Wook Lee ◽  
Hyung-Ho Ha ◽  
Marc Vendrell ◽  
Jacqueline T. Bork ◽  
Young-Tae Chang
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cross Coupling ◽  
Structural Diversity ◽  
Suzuki Coupling ◽  
Purification Step ◽  
Solid Supports ◽  
Phase Synthesis ◽  
Triazine Derivatives ◽  
Polymer Supported

A synthetic methodology to prepare collections of trisubstituted aryl 1,3,5-triazines with broad structural diversity via Suzuki coupling has been developed. We first optimized the combinatorial derivatization of the triazine core using Suzuki cross-coupling. Second, in order to further expand the methodology for the preparation of negatively charged triazines, we adapted this approach to polymer-supported amino acids and prepared aryl triazines with different charge distribution. With a collection of 160 aryl triazine derivatives in good purities and without any purification step, we proved the viability of this orthogonal scheme for the preparation of triazine libraries using amine/amino acid-captured solid supports and Suzuki cross-coupling.

scholarly journals Solid phase synthesis of functionalized indazoles using triazenes – scope and limitations

RSC Advances ◽  
2015 ◽  
Vol 5 (80) ◽  
pp. 65540-65545 ◽  
Author(s):  
Ana Maria Garcia ◽  
Nicole Jung ◽  
Carmen Gil ◽  
Martin Nieger ◽  
Stefan Bräse
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Supports ◽  
Phase Synthesis ◽  
Modular Synthesis

In this study, we present a modular synthesis of highly substituted indazoles via a strategy on solid supports.

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