scholarly journals Establishment of a long-term chick forebrain neuronal culture on a microelectrode array platform

RSC Advances ◽  
2015 ◽  
Vol 5 (69) ◽  
pp. 56244-56254 ◽  
Author(s):  
Serena Y. Kuang ◽  
Ting Huang ◽  
Zhonghai Wang ◽  
Yongliang Lin ◽  
Mark Kindy ◽  
...  
Keyword(s):  
Microelectrode Array ◽  
Microelectrode Arrays ◽  
Neuronal Culture ◽  
Neuron Culture ◽  
Array Platform ◽  
Chick Forebrain

A 5 month stable chick forebrain neuron culture was established on microelectrode arrays and characterized morphologically, functionally, and developmentally.

scholarly journals Long-term non-invasive interrogation of human dorsal root ganglion neuronal cultures on an integrated microfluidic multielectrode array platform

The Analyst ◽  
2016 ◽  
Vol 141 (18) ◽  
pp. 5346-5357 ◽  
Author(s):  
H. A. Enright ◽  
S. H. Felix ◽  
N. O. Fischer ◽  
E. V. Mukerjee ◽  
D. Soscia ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Microelectrode Array ◽  
Multielectrode Array ◽  
Neuronal Cultures ◽  
Primary Neurons ◽  
Chemical Exposures ◽  
Non Invasive ◽  
Array Platform

Electrophysiology measurements from human primary neurons after repeated chemical exposures are enabled with an integrated microfluidic and microelectrode array device.

Prolonging life in chick forebrain-neuron culture and acquiring spontaneous spiking activity on a microelectrode array

2014 ◽  
Vol 37 (3) ◽  
pp. 499-509 ◽  
Author(s):  
Serena Y. Kuang ◽  
Zhonghai Wang ◽  
Ting Huang ◽  
Lina Wei ◽  
Tingfei Xi ◽  
...  
Keyword(s):  
Microelectrode Array ◽  
Neuron Culture ◽  
Chick Forebrain ◽  
Spiking Activity

scholarly journals INITIAL SURGICAL EXPERIENCE WITH A DENSE CORTICAL MICROARRAY IN EPILEPTIC PATIENTS UNDERGOING CRANIOTOMY FOR SUBDURAL ELECTRODE IMPLANTATION

Neurosurgery ◽  
2009 ◽  
Vol 64 (3) ◽  
pp. 540-545 ◽  
Author(s):  
Allen Waziri ◽  
Catherine A. Schevon ◽  
Joshua Cappell ◽  
Ronald G. Emerson ◽  
Guy M. McKhann ◽  
...  
Keyword(s):  
Local Field ◽  
Single Unit ◽  
Microelectrode Array ◽  
Tissue Injury ◽  
Local Field Potentials ◽  
Microelectrode Arrays ◽  
Field Potentials ◽  
Surgical Experience ◽  
Electrode Implantation ◽  
Subdural Electrode

Abstract OBJECTIVE Detailed investigations of cortical physiology require the ability to record brain electrical activity at a submillimeter scale. Standard intracranial electrodes result in significant averaging of potentials generated by large numbers of neurons. In contrast, microelectrode arrays allow for recording of local field potentials and single-unit activity. We describe our initial surgical experience with the NeuroPort microelectrode array (Cyberkinetics Neurotechnology Systems, Inc., Salt Lake City, UT) in a series of patients undergoing subdural electrode implantation for epilepsy monitoring. METHODS Seven patients were implanted with and underwent semichronic recording from the NeuroPort array during standard subdural electrode monitoring for epilepsy. The electrode was placed according to company specifications in putative noneloquent epileptogenic cortex. After the monitoring period, microelectrode arrays were removed during explantation of subdural electrodes and resection of epileptogenic tissue. RESULTS Successful implantation of the microelectrode array was achieved in all patients, with minor operative difficulties. Robust and durable local field potentials and single-unit recordings were obtained from all implanted individuals. Implantation times ranged from 3 to 28 days; histological analysis of implanted tissue demonstrated no significant tissue injury or inflammatory response. There were no neurological complications or infections associated with electrode implantation or prolonged monitoring. Two patients developed postresection issues with wound healing at the site of scalp egress, with 1 requiring operative wound revision. CONCLUSION Our experience demonstrates that semichronic microelectroencephalographic recording can be safely and effectively achieved using the NeuroPort microarray. Although significant tissue injury, infection, or cerebrospinal fluid leak was not encountered, the large profile of the connection pedestal resulted in suboptimal wound closure and healing in several patients. We predict that this problem will be easily addressed in second-generation devices.

scholarly journals Hybrid Chemomechanical Promotion of PEDOT Adhesion onto Flexible Microelectrode Arrays for Chronic Neural Stimulation

2020 ◽  
Author(s):  
Mohammad Hossein Mazaheri Kouhani ◽  
Alexander Istomin ◽  
Proyag Datta ◽  
Neil H. Talbot
Keyword(s):  
Diazonium Salt ◽  
Covalent Binding ◽  
Microelectrode Arrays ◽  
Electrochemical Treatment ◽  
Neural Stimulation ◽  
Adhesion Promoter ◽  
Neural Prosthetic ◽  
Long Term Stability ◽  
Mechanical Adhesion

Advances in neural prosthetic technologies demand ever increasing novelty in material composition to enhance the mechanical and electrochemical properties of existing microelectrode arrays. Conductive polymers present advantages such as mechanical flexibility, outstanding biocompatibility, remarkable electrical properties and, most of all, cellular agreement. However, for long-term chronic applications, they fall short in their electrochemical endurance and mechanical adhesion to their substrate materials. Multiple electrochemical approaches have been investigated to improve the adherence of Poly(3,4-ethylenedioxythiophene) (PEDOT) to underlying metallic thin films. In this work, an electrochemical treatment of diazonium salt on platinum microelectrodes is incorporated as an electrochemical adhesion promoter for PEDOT and it is further combined with using the highly microporous geometry of Platinum Grey (Pt-Grey); a technology developed by Second Sight Medical Products Inc (SSMP). The intertwined mechanical integration of Pt-Grey and PEDOT molecules together with the covalent binding agency of diazonium salt demostrate a composite coating technology with long-term stability of more than 452 days while providing >70× enhancement to the interfacial capacitive impedance.

P.719 Investigation of long-term effects of ouabain administration in mice, and analysis of ouabain-induced gene expression changes in a neuronal culture

2020 ◽  
Vol 40 ◽  
pp. S408-S409
Author(s):  
A. Lopachev ◽  
A.B. Volnova ◽  
Y.A. Timoshina ◽  
R.B. Kazanskaya ◽  
M.A. Lagarkova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Neuronal Culture ◽  
Long Term Effects

Synaptogenesis and amino acid release from long term embryonic rat spinal cord neuronal culture using tissue culture inserts

2005 ◽  
Vol 141 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Martin Marsala ◽  
Osamu Kakinohana ◽  
Michael P. Hefferan ◽  
Dasa Cizkova ◽  
Kiyohiko Kinjoh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Tissue Culture ◽  
Amino Acid ◽  
Neuronal Culture ◽  
Rat Spinal Cord ◽  
Amino Acid Release ◽  
Acid Release

scholarly journals Microfabrication and characterization of an ion-selective microelectrode array platform

2005 ◽  
Vol 105 (1) ◽  
pp. 65-73 ◽  
Author(s):  
O GUENAT ◽  
J DUFOUR ◽  
P VANDERWAL ◽  
W MORF ◽  
N DEROOIJ ◽  
...  
Keyword(s):  
Microelectrode Array ◽  
Array Platform

SUCCESSFUL LONG-TERM IMPLANTATION OF ELECTRICALLY INACTIVE EPIRETINAL MICROELECTRODE ARRAYS IN RABBITS

Retina ◽  
1999 ◽  
Vol 19 (6) ◽  
pp. 546 ◽  
Author(s):  
PETER WALTER ◽  
PETER SZURMAN ◽  
MICHAEL VOBIG ◽  
HÜSNÜ BERK ◽  
HANS-CHRISTIAN LÜDTKE-HANDJERY ◽  
...  
Keyword(s):  
Microelectrode Arrays

Measurement of electrical activity of long-term mammalian neuronal networks on semiconductor neurosensor chips and comparison with conventional microelectrode arrays

2006 ◽  
Vol 21 (7) ◽  
pp. 1272-1282 ◽  
Author(s):  
Guido Krause ◽  
Stefanie Lehmann ◽  
Mirko Lehmann ◽  
Ingo Freund ◽  
Erik Schreiber ◽  
...  
Keyword(s):  
Electrical Activity ◽  
Neuronal Networks ◽  
Microelectrode Arrays
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