An insight into cochleates, a potential drug delivery system

RSC Advances ◽  
2015 ◽  
Vol 5 (99) ◽  
pp. 81188-81202 ◽  
Author(s):  
Atmaram Pawar ◽  
C. Bothiraja ◽  
Karimunnisa Shaikh ◽  
Ashwin Mali
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Lipid Bilayer ◽  
Aqueous Phase ◽  
Oral Bioavailability ◽  
Spiral Structure ◽  
Potential Drug ◽  
System P ◽  
Insight Into

Cochleates are solid particulates made up of large continuous lipid bilayer sheets rolled up in a spiral structure with little or no internal aqueous phase. Cochleates improve the oral bioavailability and efficacy of the drugs by decreasing side effects.

scholarly journals Preparation and Characterization of a Novel Swellable and Floating Gastroretentive Drug Delivery System (sfGRDDS) for Enhanced Oral Bioavailability of Nilotinib

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 137 ◽  
Author(s):  
Hong-Liang Lin ◽  
Ling-Chun Chen ◽  
Wen-Ting Cheng ◽  
Wei-Jie Cheng ◽  
Hsiu-O Ho ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
Optimal Dose ◽  
Pharmacokinetic Profile ◽  
Medical Need ◽  
Tablet Hardness

Regarding compliance and minimization of side effects of nilotinib therapy, there is a medical need to have a gastroretentive drug delivery system (GRDDS) to enhance the oral bioavailability that is able to administer an optimal dose in a quaque die (QD) or daily manner. In this study, the influence on a swelling and floating (sf) GRDDS composed of a polymeric excipient (HPMC 90SH 100K, HEC 250HHX, or PEO 7000K) and Kollidon® SR was examined. Results demonstrated that PEO 7000K/Kollidon SR (P/K) at a 7/3 ratio was determined to be a basic GRDDS formulation with optimal swelling and floating abilities. MCC PH102 or HPCsssl,SFP was further added at a 50% content to this basic formulation to increase the tablet hardness and release all of the drug within 24 h. Also, the caplet form and capsule form containing the same formulation demonstrated higher hardness for the former and enhanced floating ability for the latter. A pharmacokinetic study on rabbits with pH values in stomach and intestine similar to human confirmed that the enhanced oral bioavailability ranged from 2.65–8.39-fold with respect to Tasigna, a commercially available form of nilotinib. In conclusion, the multiple of enhancement of the oral bioavailability of nilotinib with sfGRDDS could offer a pharmacokinetic profile with therapeutic effectiveness for the QD administration of a reasonable dose of nilotinib, thereby increasing compliance and minimizing side effects.

Bioevaluation of glucose-modified liposomes as a potential drug delivery system for cancer treatment using 177-Lu radiotracking

2021 ◽  
Vol 332 ◽  
pp. 301-311
Author(s):  
Đorđe Cvjetinović ◽  
Željko Prijović ◽  
Drina Janković ◽  
Magdalena Radović ◽  
Marija Mirković ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Drug

A bio-inspired fluorescent nano-injectable hydrogel as a synergistic drug delivery system

2021 ◽  
Vol 45 (6) ◽  
pp. 3079-3087
Author(s):  
Yue Xu ◽  
Mingming Yang ◽  
Qiyue Ma ◽  
Xiang Di ◽  
Guolin Wu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Fluorescence Properties ◽  
Injectable Hydrogel ◽  
Sequential Release ◽  
System P

A nano-injectable hydrogel with fluorescence properties and controlled sequential release of dual drugs.

Improved antimicrobial activity and oral bioavailability of Delafloxacin by self-nanoemulsifying drug delivery system (SNEDDS)

2021 ◽  
pp. 102572
Author(s):  
Md. Khalid Anwer ◽  
Muzaffar Iqbal ◽  
Mohammed F. Aldawsari ◽  
Ahmed Alalaiwe ◽  
Muqtader Mohammad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antimicrobial Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability

Annexin V-Conjugated Mixed Micelles as a Potential Drug Delivery System for Targeted Thrombolysis

2017 ◽  
Vol 18 (3) ◽  
pp. 865-876 ◽  
Author(s):  
Yang Pan ◽  
Xiaoting Ren ◽  
Shuang Wang ◽  
Xin Li ◽  
Xianglin Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mixed Micelles ◽  
Annexin V ◽  
Potential Drug

scholarly journals Design and development of microemulsion drug delivery system of acyclovir for improvement of oral bioavailability

2006 ◽  
Vol 7 (3) ◽  
Author(s):  
Pradip Kumar Ghosh ◽  
Rita J. Majithiya ◽  
Manish L. Umrethia ◽  
Rayasa S. R. Murthy
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
Design And Development

scholarly journals Paclitaxel-loaded folate-coated long circulating and pH-sensitive liposomes as a potential drug delivery system: A biodistribution study

2018 ◽  
Vol 97 ◽  
pp. 489-495 ◽  
Author(s):  
Liziane O.F. Monteiro ◽  
Renata S. Fernandes ◽  
Caroline M.R. Oda ◽  
Sávia C. Lopes ◽  
Danyelle M. Townsend ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Biodistribution Study ◽  
Potential Drug ◽  
System A

Novel “soft” biodegradable nanoparticles prepared from aliphatic based monomers as a potential drug delivery system

Soft Matter ◽  
2012 ◽  
Vol 8 (16) ◽  
pp. 4343 ◽  
Author(s):  
Alessandro Jäger ◽  
Daniel Gromadzki ◽  
Eliézer Jäger ◽  
Fernando Carlos Giacomelli ◽  
Agnieszka Kozlowska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Drug ◽  
Biodegradable Nanoparticles
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