scholarly journals Responsive pentablock copolymers for siRNA delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (54) ◽  
pp. 43515-43527 ◽  
Author(s):  
Metin Uz ◽  
Surya K. Mallapragada ◽  
Sacide Alsoy Altinkaya
Keyword(s):  
Sirna Delivery ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Pentablock Copolymers ◽  
First Time

Temperature and pH responsive pentablock copolymers were used for the first time in developing polyplex and multicomponent siRNA delivery systems.

Lipid-based siRNA Delivery Systems

2012 ◽  
Vol 39 (5) ◽  
pp. 396-401 ◽  
Author(s):  
Wen-Juan DONG ◽  
Yin-Jian ZHOU ◽  
Wei LIANG
Keyword(s):  
Sirna Delivery ◽  
Delivery Systems

pH responsive chitosan-coated microemulsions as drug delivery systems

2020 ◽  
pp. 1-12
Author(s):  
Daniela Díaz-Zepeda ◽  
René D. Peralta-Rodríguez ◽  
Bertha Puente-Urbina ◽  
Gladis Cortez-Mazatan ◽  
H. Iván Meléndez-Ortiz
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Responsive

scholarly journals The Nanosystems Involved in Treating Lung Cancer

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 682
Author(s):  
Andreea Crintea ◽  
Alina Gabriela Dutu ◽  
Gabriel Samasca ◽  
Ioan Alexandru Florian ◽  
Iulia Lupan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Side Effects ◽  
Chromosomal Rearrangements ◽  
Sirna Delivery ◽  
Delivery Systems ◽  
Inorganic Nanoparticles ◽  
New Methods ◽  
Different Types ◽  
Or Gene ◽  
The Many

Even though there are various types of cancer, this pathology as a whole is considered the principal cause of death worldwide. Lung cancer is known as a heterogeneous condition, and it is apparent that genome modification presents a significant role in the occurrence of this disorder. There are conventional procedures that can be utilized against diverse cancer types, such as chemotherapy or radiotherapy, but they are hampered by the numerous side effects. Owing to the many adverse events observed in these therapies, it is imperative to continuously develop new and improved strategies for managing individuals with cancer. Nanomedicine plays an important role in establishing new methods for detecting chromosomal rearrangements and mutations for targeted chemotherapeutics or the local delivery of drugs via different types of nano-particle carriers to the lungs or other organs or areas of interest. Because of the complex signaling pathways involved in developing different types of cancer, the need to discover new methods for prevention and detection is crucial in producing gene delivery materials that exhibit the desired roles. Scientists have confirmed that nanotechnology-based procedures are more effective than conventional chemotherapy or radiotherapy, with minor side effects. Several nanoparticles, nanomaterials, and nanosystems have been studied, including liposomes, dendrimers, polymers, micelles, inorganic nanoparticles, such as gold nanoparticles or carbon nanotubes, and even siRNA delivery systems. The cytotoxicity of such nanosystems is a debatable concern, and nanotechnology-based delivery systems must be improved to increase the bioavailability, biocompatibility, and safety profiles, since these nanosystems boast a remarkable potential in many biomedical applications, including anti-tumor activity or gene therapy. In this review, the nanosystems involved in treating lung cancer and its associated challenges are discussed.

Doubly dendronized poly(norbornene)s as siRNA delivery systems

Polymer ◽  
2021 ◽  
pp. 123680
Author(s):  
Sung Hyun Cho ◽  
Ho-Joong Kim ◽  
Dong-Hyun Lee ◽  
Si Kyung Yang
Keyword(s):  
Sirna Delivery ◽  
Delivery Systems

A water-soluble hybrid[4]arene: synthesis, host–guest complexation and application in the construction of a supra-amphiphile

2016 ◽  
Vol 40 (5) ◽  
pp. 4756-4760 ◽  
Author(s):  
Bin Hua ◽  
Li Shao ◽  
Jiong Zhou ◽  
Guocan Yu
Keyword(s):  
Water Soluble ◽  
Ph Responsive ◽  
New Host ◽  
Recognition Motif ◽  
First Time

A water-soluble hybrid[4]arene was synthesized for the first time and its pH-responsive host–guest complexation with paraquat in water was investigated. This new host–guest recognition motif was further applied in the construction of a supra-amphiphile.

scholarly journals pH-Responsive Release of Ruthenium Metallotherapeutics from Mesoporous Silica-Based Nanocarriers

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 460
Author(s):  
Minja Mladenović ◽  
Ibrahim Morgan ◽  
Nebojša Ilić ◽  
Mohamad Saoud ◽  
Marija V. Pergal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Inductively Coupled Plasma ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Emission Spectrometry ◽  
Ph Responsive

Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.

Recent advances in siRNA delivery systems for prostate cancer therapy

2021 ◽  
Vol 22 ◽  
Author(s):  
Shahin Aghamiri ◽  
Pourya Raee ◽  
Shiva Shahmohamadnejad ◽  
Sasan Shabani ◽  
Jaber Ghorbani ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Sirna Delivery ◽  
Delivery Systems ◽  
Multi Drug Resistance ◽  
New Paradigm ◽  
Polymeric Systems ◽  
Chemotherapy Drugs ◽  
Prostate Cancer Therapy ◽  
Effective Delivery ◽  
Critical Problems

: The critical problems of conventional prostate cancer therapeutic strategies like nonspecific toxicity and multi-drug resistance prompted the development and application of countless nanoparticle-based siRNA therapeutics. The main challenges to siRNA-based therapeutics becoming a new paradigm in the treatment of prostate cancer stem from the lack of safe and effective delivery systems, immune system stimulation, poor knowledge of nano-bio interactions, and limitations concerning designing, manufacturing, clinical translation, and commercialization. In this review, we provide cutting-edge advances in nanoparticle-mediated siRNA delivery carriers like polymeric systems, lipid systems, specific systems, and rigid nanoparticles for the treatment of prostate cancer. Moreover, co-delivery of conventional chemotherapy drugs with siRNA as a robust revolutionary strategy for prostate cancer combinational therapy is completely covered.

scholarly journals Self-aggregated nanoparticles of N -dodecyl,N ′-glycidyl(chitosan) as pH-responsive drug delivery systems for quercetin

2017 ◽  
Vol 135 (2) ◽  
pp. 45678 ◽  
Author(s):  
Rafael de Oliveira Pedro ◽  
Susana Pereira ◽  
Francisco M. Goycoolea ◽  
Carla C. Schmitt ◽  
Miguel G. Neumann
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Responsive

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

2014 ◽  
Vol 50 (58) ◽  
pp. 7824-7827 ◽  
Author(s):  
Minghui Zan ◽  
Junjie Li ◽  
Shizhong Luo ◽  
Zhishen Ge
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Lysosomal Ph ◽  
Tumor Acidity

The multistage polymeric nanogel delivery systems were constructed via host–guest interactions, which showed tumor acidity-triggered disassembly into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

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