Cationic benzylidene cyclopentanone photosensitizers for selective photodynamic inactivation of bacteria over mammalian cells

RSC Advances ◽  
2015 ◽  
Vol 5 (69) ◽  
pp. 56067-56074 ◽  
Author(s):  
Yanyan Fang ◽  
Tianlong Liu ◽  
Qianli Zou ◽  
Yuxia Zhao ◽  
Feipeng Wu
Keyword(s):  
Mammalian Cells ◽  
Photodynamic Inactivation ◽  
Bacterial Cells ◽  
Inactivation Of Bacteria

Cationic modified benzylidene cyclopentanone photosensitizers selectively photo-inactivate bacterial cells over mammalian cells.

Selective Photodynamic Inactivation of Bacterial Cells over Mammalian Cells by New Triarylmethanes

Langmuir ◽  
2014 ◽  
Vol 30 (48) ◽  
pp. 14573-14580 ◽  
Author(s):  
Ke Li ◽  
Wanhua Lei ◽  
Guoyu Jiang ◽  
Yuanjun Hou ◽  
Baowen Zhang ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Photodynamic Inactivation ◽  
Bacterial Cells

scholarly journals The Use of Bacteriophage for Detection and Biocontrol of Foodborne Pathogen

2018 ◽  
Vol 28 (1) ◽  
pp. 33
Author(s):  
Tati Ariyanti
Keyword(s):  
Mammalian Cells ◽  
Food Industry ◽  
Pathogenic Bacteria ◽  
Foodborne Pathogen ◽  
Foodborne Disease ◽  
Bacterial Cells ◽  
Detection Tool ◽  
Specific Receptors ◽  
Antibiotics Detection ◽  
Potential Use

Bacteriophages are viruses that have ability to attack bacterial cells in specific receptors, infect, multiply in bacterial cells and eventually lyse bacterial cells. This unique bacteriophage character is highly beneficial because it is harmless to mammalian cells and does not interfere with natural microbes. Bacteriophages are easy to obtain because they are widespread in the environment such as soil, water, animal, and farm waste or food. This paper describes the potential use of bacteriophages to detect pathogen and foodborne pathogen biocontrol. Bacteriophages are very potential to control the growth of pathogenic bacteria both in food industry and environment. Bacteriophages act as antibiotics, detection tool for pathogenic bacteria in the food chain, food biopreservative from pathogen bacteria contamination, and foodborne disease prevention. Although research on bacteriophage in Indonesia has not been widely reported, research on bacteriophage utilization is being carried on.

Role of an endoplasmic reticulum Ca2+-independent phospholipase A2 in oxidant-induced renal cell death

2002 ◽  
Vol 283 (3) ◽  
pp. F492-F498 ◽  
Author(s):  
Brian S. Cummings ◽  
Jane McHowat ◽  
Rick G. Schnellmann
Keyword(s):  
Lipid Peroxidation ◽  
Endoplasmic Reticulum ◽  
Subcellular Localization ◽  
Mammalian Cells ◽  
Cumene Hydroperoxide ◽  
Physiological Role ◽  
Antimycin A ◽  
Bacterial Cells ◽  
Tert Butylhydroperoxide ◽  
Membrane Bound

Phospholipase A2(PLA2) hydrolyzes the sn-2 ester bond in phospholipids, releasing a fatty acid and a lysophospholipid. Recently, a novel 85-kDa membrane-bound-Ca2+-independent PLA2 (iPLA2) was identified in insect and bacterial cells transfected with candidate PLA2 sequences. However, few data exist demonstrating a membrane-bound-iPLA2 in mammalian cells, its subcellular localization, or its physiological role. Herein, we demonstrate the expression of an 85-kDa endoplasmic reticulum (ER)-Ca2+-iPLA2 (ER-iPLA2) in rabbit renal proximal tubule cells (RPTC) that is plasmalogen selective and is inhibited by the specific Ca2+-iPLA2inhibitor bromoenol lactone (BEL). RPTC exposed to tert-butylhydroperoxide for 24 h exhibited 20% oncosis compared with 2% in controls. Inhibition of ER-iPLA2 with BEL before tert-butylhydroperoxide exposure resulted in 50% oncosis. To determine whether this effect was common to oxidants, we tested the ability of BEL to potentiate oncosis induced by cumene hydroperoxide, menadione, duraquinone, cisplatin, and the nonoxidant antimycin A. All oxidants tested produced oncosis after 24 h, and prior inhibition of ER-iPLA2 potentiated oncosis at least twofold. In contrast, inhibition of ER-iPLA2 did not alter antimycin A-induced oncosis. Lipid peroxidation increased from 1.4- to 5.2-fold in RPTC treated with BEL before oxidant exposure, whereas no change was seen in antimycin A-treated RPTC. These results are the first to demonstrate the expression and subcellular localization of an ER-iPLA2. These results also suggest that ER-iPLA2 functions to protect against oxidant-induced lipid peroxidation and oncosis.

Attachment of Salmonella to mammalian cells in vitro

1983 ◽  
Vol 29 (12) ◽  
pp. 1731-1735 ◽  
Author(s):  
Clifford S. Mintz ◽  
Dean O. Cliver ◽  
R. H. Deibel
Keyword(s):  
Cell Lines ◽  
Mammalian Cells ◽  
Culture Cell ◽  
Intestinal Cell ◽  
Tissue Culture Cell ◽  
Bacterial Cells ◽  
Intestinal Cell Line ◽  
Hela Cell Lines ◽  
High Concentrations

The attachment of Salmonella typhimurium strain PHL67342 to several mammalian tissue culture cell lines was investigated. Strain PHL67342 failed to attach in significant numbers to the Buffalo green monkey (BGM), swine testicular (ST), and HeLa cell lines. Significant attachment was observed with the Henle intestinal cell line. Log-phase cells of strain PHL67342 attached in greatest numbers to the Henle cells after 45 min of incubation at 37 °C. Attachment to the Henle cells was not affected by D-mannose or D-galactose, but was markedly inhibited by high concentrations of alpha-methyl-D-mannoside. Also, Salmonella lipopolysaccharide had no effect on the attachment of strain PHL67342 to the Henle cells. Fimbriae were not detected on the bacterial cells used in the adherence experiments. These results suggest that some bacterial factor(s) other than fimbriae and lipopolysaccharide mediate the attachment of strain PHL67342 to the Henle cells.

Photodynamic Inactivation of Bacteria Using Novel Electrogenerated Porphyrin-Fullerene C60 Polymeric Films

2015 ◽  
Vol 49 (12) ◽  
pp. 7456-7463 ◽  
Author(s):  
M. Belén Ballatore ◽  
Javier Durantini ◽  
Natalia S. Gsponer ◽  
María B. Suarez ◽  
Miguel Gervaldo ◽  
...  
Keyword(s):  
Fullerene C60 ◽  
Polymeric Films ◽  
Photodynamic Inactivation ◽  
Inactivation Of Bacteria

Conjugated Polyelectrolytes with Imidazolium Solubilizing Groups. Properties and Application to Photodynamic Inactivation of Bacteria

2015 ◽  
Vol 7 (51) ◽  
pp. 28027-28034 ◽  
Author(s):  
Anand Parthasarathy ◽  
Harry C. Pappas ◽  
Eric H. Hill ◽  
Yun Huang ◽  
David G. Whitten ◽  
...  
Keyword(s):  
Photodynamic Inactivation ◽  
Conjugated Polyelectrolytes ◽  
Inactivation Of Bacteria

Improving Photodynamic Inactivation of Bacteria in Dentistry: Highly Effective and Fast Killing of Oral Key Pathogens with Novel Tooth-Colored Type-II Photosensitizers

2014 ◽  
Vol 57 (12) ◽  
pp. 5157-5168 ◽  
Author(s):  
Andreas Späth ◽  
Christoph Leibl ◽  
Fabian Cieplik ◽  
Karin Lehner ◽  
Johannes Regensburger ◽  
...  
Keyword(s):  
Photodynamic Inactivation ◽  
Type Ii ◽  
Highly Effective ◽  
Inactivation Of Bacteria
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