Photophysical behavior and photodynamic therapy activity of conjugates of zinc monocarboxyphenoxy phthalocyanine with human serum albumin and chitosan

2017 ◽  
Vol 173 ◽  
pp. 292-300 ◽  
Author(s):  
David O. Oluwole ◽  
Earl Prinsloo ◽  
Tebello Nyokong
Keyword(s):  
Photodynamic Therapy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Photophysical Behavior

scholarly journals Human serum albumin nanoparticles loaded with phthalocyanine dyes for potential use in photodynamic therapy for atherosclerotic plaques

2019 ◽  
Vol 2 (2) ◽  
pp. 279-302 ◽  
Author(s):  
Subhadeep Banerjee ◽  
Jayeeta Sengupta ◽  
Ana Isabel Aljarilla ◽  
Francesca Setaro ◽  
Petri Makinen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Contrast Agent ◽  
Human Serum ◽  
Zinc Phthalocyanine ◽  
Atherosclerotic Plaques ◽  
Albumin Nanoparticles ◽  
Vulnerable Plaques ◽  
Potential Use

Diseases caused by obstruction or rupture of vulnerable plaques in the arterial walls such as cardiovascular infarction or stroke are the leading cause of death in the world. In the present work, we developed human serum albumin nanoparticles loaded by physisorption with zinc phthalocyanine, TT1, mainly used for industrial application as near-infrared photosensitizer and compared these to HSA NPs loaded with the well-known silicone phthalocyanine (Pc4). The use of NIR light allows for better tissue penetration, while the use of nanoparticles permits high local concentrations. The particles were characterized and tested for toxicity and stability as well as for their potential use as a contrast agent and NIR photosensitizer for photodynamic therapy in cardiovascular disease. We focused on the distribution of the nanoparticles in RAW264.7 macrophage cells and atherosclerotic mice. The nanoparticles had an average size of 120 nm according to dynamic light scattering, good loading capacity for zinc phthalocyanine, and satisfying stability in 50% (v/v) fetal bovine serum for 8 hours and in an aqueous environment at 4°C for 4–6 weeks. Under light irradiation we found a high production of singlet oxygen and the products showed no dark toxicity in vitro with macrophages (the target cells in vulnerable plaques), but at a low g/mL nanoparticle concentration killed efficiently the macrophages upon LED illumination. Injection of the contrast agent in atherosclerotic mice led to a visible fluorescence signal of zinc phthalocyanine in the atherosclerotic plaque at 30 minutes and in the lungs with a fast clearance of the nanoparticles. Zinc phthalocyanine loaded human serum albumin nanoparticles present an interesting candidate for the visualization and potentially photodynamic treatment of macrophages in atherosclerotic plaques.

Targeted photosensitizer nanoconjugates based on human serum albumin selectively kill tumor cells upon photo-irradiation

RSC Advances ◽  
2015 ◽  
Vol 5 (62) ◽  
pp. 50572-50579 ◽  
Author(s):  
Cheng-Yi Tang ◽  
Yong-hui Liao ◽  
Guo-Sheng Tan ◽  
Xiao-Ming Wang ◽  
Gui-Hua Lu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Cells

Small and non-toxic nanoconjugates RGD–HSA–Ce6 could provide targeted and effective photodynamic therapy of tumor cells.

Hydrophobic IR780 encapsulated in biodegradable human serum albumin nanoparticles for photothermal and photodynamic therapy

2015 ◽  
Vol 14 ◽  
pp. 61-69 ◽  
Author(s):  
Chenxiao Jiang ◽  
Hao Cheng ◽  
Ahu Yuan ◽  
Xiaolei Tang ◽  
Jinhui Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Albumin Nanoparticles

Biosupramolecular complexes of amphiphilic photosensitizers with human serum albumin and cucurbit[7]uril as carriers for photodynamic therapy

2021 ◽  
pp. 112284
Author(s):  
José Robinson-Duggon ◽  
Christopher D. McTiernan ◽  
Marcelo Muñoz ◽  
Daniel Guerra ◽  
Elizabeth Escobar Álvarez ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum

scholarly journals Photophysical Behavior and the Binding to Human Serum Albumin of a Novel Triazole Compound

2013 ◽  
Vol 71 (5) ◽  
pp. 837
Author(s):  
Wenying He ◽  
Hongzong Si ◽  
Feng Luan ◽  
Luyong Wu ◽  
Jilong Zhou ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Photophysical Behavior
Sign in / Sign up

Export Citation Format

Share Document