Comparative study of normal, micro- & nano-sized iron oxide effect in potentiometric determination of fluconazole in biological fluids

RSC Advances ◽  
2015 ◽  
Vol 5 (47) ◽  
pp. 37957-37963 ◽  
Author(s):  
Lobna A. Hussein ◽  
Amira M. El-Kosasy ◽  
Yossra A. Trabik
Keyword(s):  
Iron Oxide ◽  
Comparative Study ◽  
Polyvinyl Chloride ◽  
Biological Fluids ◽  
Polymeric Matrix ◽  
Potentiometric Determination

Three novel fluconazole (FLU) selective electrodes were investigated with di-octyl phthalate as a plasticizer in a polymeric matrix of polyvinyl chloride and 2-hydroxypropyl-β-cyclodextrin as an ionophore.

scholarly journals Determination of Hydroxyurea in Capsules and Biological Fluids by Ion-Selective Potentiometry and Fluorimetry

2003 ◽  
Vol 86 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Amira M El-Kosasy
Keyword(s):  
Polyvinyl Chloride ◽  
Biological Fluids ◽  
Polymeric Matrix ◽  
Complex Method ◽  
Anionic Site ◽  
The Stability ◽  
The U.S ◽  
Mg Complexes

Abstract Two hydroxyurea selective electrodes were investigated with β-cyclodextrin used as ionophore and either tetrakis (p-chlorophenyl) borate (electrode 1), or tetrakis [3,4-bis (trifluoromethyl) phenyl] borate (electrode 2), as a fixed anionic site in a polymeric matrix of carboxylated polyvinyl chloride. Linear responses of hydroxyurea within a concentration range of 10−5–10−3M with slopes of 51.2 and 58.6 mV/decade with pH 3–6 were obtained by using electrodes 1 and 2, respectively. Two spectrofluorimetric methods involving the formation of drug–Al(III) complex (method 3) and drug–Mg(II) complex (method 4) at pH 5 were also investigated. These complexes emit fluorescence at wavelengths of 380 and 355 nm, after excitation at 305 nm, for Al and Mg complexes, respectively. The calibration graphs were rectilinear from 0.5 to 2.5 μg/mL for the Al complex and 1 to 5 μg/mL for the Mg complex. The 4 proposed methods display useful analytical characteristics for determination of hydroxyurea, with average recoveries of 100.2 ± 0.83 and 99.4 ± 1.81% in capsules and 99.7 ± 0.70 and 99.4 ± 1.25% in biological fluids for the potentiometric and fluorimetric methods, respectively. Results obtained by the proposed procedures were statistically analyzed and compared with those obtained by the U.S. Pharmacopeial method. The 4 proposed procedures were also used to determine the stability of the drug in the presence of its degradate, hydroxylamine.

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