Rapid quantification of a chemically synthesized peptide GAP162 in rat plasma by liquid chromatography/triple quadrupole tandem mass spectrometry and application to a pharmacokinetic study

RSC Advances ◽  
2015 ◽  
Vol 5 (64) ◽  
pp. 51708-51716
Author(s):  
Xiaoping Zhao ◽  
Liping Kang ◽  
Taichang Zhang ◽  
Jianhua Chen ◽  
Xinyi Ren ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Biological Fluids ◽  
Rat Plasma ◽  
Tandem Mass ◽  
Triple Quadrupole ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Rapid Quantification

Liquid chromatography/tandem mass spectrometry (LC-MS/MS) is a promising analytical platform for the quantification of therapeutic peptide in biological fluids for pharmacokinetics (PK) studies.

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