Diketo acids and their amino acid/dipeptidic analogues as promising scaffolds for the development of bacterial methionine aminopeptidase inhibitors

RSC Advances ◽  
2015 ◽  
Vol 5 (43) ◽  
pp. 34173-34183 ◽  
Author(s):  
Mir Mohammad Masood ◽  
Vijay K. Pillalamarri ◽  
Mohammad Irfan ◽  
Babita Aneja ◽  
Mohamad Aman Jairajpuri ◽  
...  
Keyword(s):  
Amino Acid ◽  
Enzymatic Assay ◽  
Methionine Aminopeptidase ◽  
Diketo Acids ◽  
Aminopeptidase Inhibitors

Diketo acids and their peptidic analogues were designed and synthesised as bacterial MetAP inhibitors. In the enzymatic assay, the representative compound 5e showed excellent inhibition of bacterial MetAPs with no cytotoxicity.

Ionic Immobilization, Diversification, and Release: Application to the Generation of a Library of Methionine Aminopeptidase Inhibitors

2008 ◽  
Vol 10 (2) ◽  
pp. 185-194 ◽  
Author(s):  
Punitha Vedantham ◽  
Jennifer M. Guerra ◽  
Frank Schoenen ◽  
Min Huang ◽  
Parul J. Gor ◽  
...  
Keyword(s):  
Methionine Aminopeptidase ◽  
Aminopeptidase Inhibitors

scholarly journals New Enzymatic Assay for Glycohemoglobin

2003 ◽  
Vol 49 (2) ◽  
pp. 269-274 ◽  
Author(s):  
Ikunosuke Sakurabayashi ◽  
Tatsurou Watano ◽  
Satoshi Yonehara ◽  
Kaori Ishimaru ◽  
Kaoru Hirai ◽  
...  
Keyword(s):  
Amino Acid ◽  
Blood Cells ◽  
Hplc Method ◽  
Enzymatic Assay ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Blood Samples ◽  
Total Hemoglobin ◽  
Patients With Diabetes ◽  
Fructosyl Amino Acid Oxidase

Abstract Background: Previous methods to measure glycohemoglobin (GHb) have been time-consuming or imprecise; we therefore developed a new enzymatic assay for GHb. Methods: Blood cells were first hemolyzed, and hemoglobin was digested with protease to yield fructosyl amino acid. Fructosyl amino acid oxidase acts on the fructosyl amino acid and generates hydrogen peroxide, which reacts with chromogens in the presence of peroxidase. Total hemoglobin was measured spectrometrically in the same reaction tube. The results were reported as the ratio of the concentrations of GHb and hemoglobin. Results: The measured values were comparable to those determined with a HPLC method and with an immunoassay in blood samples from 2854 patients with diabetes. Regression analysis for the enzymatic assay (y) vs the HPLC method (x) produced the following: r = 0.979; slope, 0.994 [95% confidence interval (CI), 0.986–1.001]; y-intercept, 0.04% (95% CI, −0.09% to 0.01%); n = 2854. For the enzymatic assay (y) vs the immunoassay (x), the regression statistics were as follows: r = 0.982; slope, 1.002 (95% CI, 0.995–1.009); y-intercept, 0% (95% CI, −0.05% to 0.05%); n = 2854. Conclusions: The values measured by the new enzymatic assay are sufficiently correlated with those of the conventional HPLC method and immunoassay, but the proposed assay for GHb is rapid and has high precision.

Investigations and design of pyridine-2-carboxylic acid thiazol-2-ylamide analogs as methionine aminopeptidase inhibitors using 3D-QSAR and molecular docking

2014 ◽  
Vol 23 (8) ◽  
pp. 3861-3875 ◽  
Author(s):  
Potshangbam Angamba Meetei ◽  
Alexander S. Hauser ◽  
Prathigadapa S. Raju ◽  
R. S. Rathore ◽  
N. Prakash Prabhu ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Carboxylic Acid ◽  
3D Qsar ◽  
Methionine Aminopeptidase ◽  
Aminopeptidase Inhibitors

Methionine Aminopeptidase Inhibitors in Mammalian Cells

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Natalia Condic ◽  
Cassandra Ramtahal ◽  
Jamila Boukari ◽  
Alex Croes ◽  
Calvin Nguyen ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Methionine Aminopeptidase ◽  
Aminopeptidase Inhibitors

Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors

2004 ◽  
Vol 14 (1) ◽  
pp. 77-79 ◽  
Author(s):  
Xubo Hu ◽  
Jinge Zhu ◽  
Sumant Srivathsan ◽  
Dehua Pei
Keyword(s):  
Hydroxamic Acids ◽  
Methionine Aminopeptidase ◽  
Aminopeptidase Inhibitors

Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors

2010 ◽  
Vol 20 (14) ◽  
pp. 4038-4044 ◽  
Author(s):  
Markus A. Altmeyer ◽  
Aline Marschner ◽  
Rolf Schiffmann ◽  
Christian D. Klein
Keyword(s):  
Methionine Aminopeptidase ◽  
Subtype Selectivity ◽  
Aminopeptidase Inhibitors

Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors

2006 ◽  
Vol 66 (3) ◽  
pp. 538-546 ◽  
Author(s):  
Artem G. Evdokimov ◽  
Matthew Pokross ◽  
Richard L. Walter ◽  
Marlene Mekel ◽  
Bobby L. Barnett ◽  
...  
Keyword(s):  
Methionine Aminopeptidase ◽  
Aminopeptidase Inhibitors

scholarly journals Potential Cytotoxicity of Methionine Aminopeptidase Inhibitors on Mammalian Cells

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Alex Croes ◽  
Jamila Boukari ◽  
Melissa Alvarez ◽  
Jennifer Clymer ◽  
Robert Flores ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Methionine Aminopeptidase ◽  
Aminopeptidase Inhibitors
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