Nanostructure and cytotoxicity of self-assembled monoolein–capric acid lyotropic liquid crystalline nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (34) ◽  
pp. 26785-26795 ◽  
Author(s):  
Nhiem Tran ◽  
Xavier Mulet ◽  
Adrian M. Hawley ◽  
Tracey M. Hinton ◽  
Stephen T. Mudie ◽  
...  
Keyword(s):  
Liquid Crystalline ◽  
Capric Acid ◽  
Bicontinuous Cubic ◽  
Liquid Crystalline Nanoparticles ◽  
Self Assembled

Monoolein–capric acid combinations form into particles with internal nanostructures, including inverse hexagonal and bicontinuous cubic mesophases, with differing cytotoxicity.

scholarly journals Self-Assembled Cubic Liquid Crystalline Nanoparticles for Transdermal Delivery of Paeonol

2015 ◽  
Vol 21 ◽  
pp. 3298-3310 ◽  
Author(s):  
Jian-Chun Li ◽  
Na Zhu ◽  
Jin-Xiu Zhu ◽  
Wen-Jing Zhang ◽  
Hong-Min Zhang ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Liquid Crystalline ◽  
Liquid Crystalline Nanoparticles ◽  
Self Assembled

scholarly journals Formation of Self-Assembled Liquid Crystalline Nanoparticles and Absorption Enhancement of Ω-3s by Phospholipids and Oleic Acids

Pharmaceutics ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 68
Author(s):  
Sang-Won Jeon ◽  
Han-Sol Jin ◽  
Young-Joon Park
Keyword(s):  
Oleic Acid ◽  
Liquid Crystal ◽  
Oral Bioavailability ◽  
Liquid Crystalline ◽  
In Vitro Dissolution ◽  
Absorption Enhancement ◽  
Epa And Dha ◽  
Liquid Crystalline Nanoparticles ◽  
Self Assembled ◽  
The Impact

This study aimed to optimize and evaluate self-assembled liquid crystalline nanoparticles (SALCs) prepared from phospholipids and oleic acid for enhancing the absorption of ω-3s. We explored the structure and optimal formulation of SALCs, which are composed of ω-3 ethyl ester (ω-3 EE), phospholipids, and oleic acid, using a ternary diagram and evaluated the improvement in ω-3 dissolution, permeation, and oral bioavailability. The in vitro dissolution and pharmacokinetics of ω-3 SALCs were compared with those of Omacor soft capsules (as the reference). The shape of the liquid crystal was determined according to the composition of phospholipids, oleic acids, and ω-3s and was found to be in cubic, lamellar, and hexagonal forms. The dissolution rates of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) obtained from ω-3 SALCs were 1.7 to 2.3-fold higher than those of the Omacor soft capsules. Furthermore, a pharmacokinetic study in male beagle dogs revealed that ω-3 SALCs increased the oral bioavailability of ω-3 EE by 2.5-fold for EPA and 3.1-fold for DHA compared with the reference. We found an optimal formulation that spontaneously forms liquid crystal-based nanoparticles, improving the bioavailability of EPA and DHA, not found in the existing literature. Our findings offer insight into the impact of nanoparticle phase on the oral delivery of oil-soluble drugs and provide a novel ω-3 EE formulation that improves the bioavailability of EPA and DHA.

Bioimaging Applications of Non-Lamellar Liquid Crystalline Nanoparticles

2021 ◽  
Vol 21 (5) ◽  
pp. 2742-2759
Author(s):  
Sergio Murgia ◽  
Stefania Biffi ◽  
Marco Fornasier ◽  
Vito Lippolis ◽  
Giacomo Picci ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Liquid Crystalline ◽  
Colloidal Nanoparticles ◽  
Self Assembling ◽  
Complex Architectures ◽  
Imaging Probes ◽  
Bicontinuous Cubic ◽  
Liquid Crystalline Nanoparticles

Self-assembling processes of amphiphilic lipids in water give rise to complex architectures known as lyotropic liquid crystalline (LLC) phases. Particularly, bicontinuous cubic and hexagonal LLC phases can be dispersed in water forming colloidal nanoparticles respectively known as cubosomes and hexosomes. These non-lamellar LLC dispersions are of particular interest for pharmaceutical and biomedical applications as they are potentially non-toxic, chemically stable, and biocompatible, also allowing encapsulation of large amounts of drugs. Furthermore, conjugation of specific moieties enables their targeting, increasing therapeutic efficacies and reducing side effects by avoiding exposure of healthy tissues. In addition, as they can be easy loaded or functionalized with both hydrophobic and hydrophilic imaging probes, cubosomes and hexosomes can be used for the engineering of multifunctional/theranostic nanoplatforms. This review outlines recent advances in the applications of cubosomes and hexosomes for in vitro and in vivo bioimaging.

Self-Assembled Geometric Liquid-Crystalline Nanoparticles Imaged in Three Dimensions:  Hexosomes Are Not Necessarily Flat Hexagonal Prisms

Langmuir ◽  
2007 ◽  
Vol 23 (25) ◽  
pp. 12461-12464 ◽  
Author(s):  
Ben J. Boyd ◽  
Shakila B. Rizwan ◽  
Yao-Da Dong ◽  
Sarah Hook ◽  
Thomas Rades
Keyword(s):  
Liquid Crystalline ◽  
Three Dimensions ◽  
Liquid Crystalline Nanoparticles ◽  
Self Assembled

scholarly journals Lipase Action on Self-Assembled Lipid Liquid Crystalline Nanoparticles

2011 ◽  
Vol 100 (3) ◽  
pp. 503a
Author(s):  
Justas Barauskas ◽  
Daniel Anderberg ◽  
Allan Svendsen ◽  
Tommy Nylander
Keyword(s):  
Liquid Crystalline ◽  
Liquid Crystalline Nanoparticles ◽  
Self Assembled

Self-assembled Lyotropic Liquid Crystalline Phase Behavior of Monoolein–Capric Acid–Phospholipid Nanoparticulate Systems

Langmuir ◽  
2017 ◽  
Vol 33 (10) ◽  
pp. 2571-2580 ◽  
Author(s):  
Jiali Zhai ◽  
Nhiem Tran ◽  
Sampa Sarkar ◽  
Celesta Fong ◽  
Xavier Mulet ◽  
...  
Keyword(s):  
Phase Behavior ◽  
Crystalline Phase ◽  
Liquid Crystalline ◽  
Capric Acid ◽  
Liquid Crystalline Phase ◽  
Self Assembled ◽  
Nanoparticulate Systems
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