Steric stabilisation of self-assembled cubic lyotropic liquid crystalline nanoparticles: high throughput evaluation of triblock polyethylene oxide-polypropylene oxide-polyethylene oxide copolymers

Soft Matter ◽  
2011 ◽  
Vol 7 (10) ◽  
pp. 4768 ◽  
Author(s):  
Josephine Y. T. Chong ◽  
Xavier Mulet ◽  
Lynne J. Waddington ◽  
Ben J. Boyd ◽  
Calum J. Drummond
Keyword(s):  
High Throughput ◽  
Polyethylene Oxide ◽  
Liquid Crystalline ◽  
Polypropylene Oxide ◽  
Liquid Crystalline Nanoparticles ◽  
Self Assembled ◽  
Steric Stabilisation

scholarly journals Self-Assembled Cubic Liquid Crystalline Nanoparticles for Transdermal Delivery of Paeonol

2015 ◽  
Vol 21 ◽  
pp. 3298-3310 ◽  
Author(s):  
Jian-Chun Li ◽  
Na Zhu ◽  
Jin-Xiu Zhu ◽  
Wen-Jing Zhang ◽  
Hong-Min Zhang ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Liquid Crystalline ◽  
Liquid Crystalline Nanoparticles ◽  
Self Assembled

scholarly journals Formation of Self-Assembled Liquid Crystalline Nanoparticles and Absorption Enhancement of Ω-3s by Phospholipids and Oleic Acids

Pharmaceutics ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 68
Author(s):  
Sang-Won Jeon ◽  
Han-Sol Jin ◽  
Young-Joon Park
Keyword(s):  
Oleic Acid ◽  
Liquid Crystal ◽  
Oral Bioavailability ◽  
Liquid Crystalline ◽  
In Vitro Dissolution ◽  
Absorption Enhancement ◽  
Epa And Dha ◽  
Liquid Crystalline Nanoparticles ◽  
Self Assembled ◽  
The Impact

This study aimed to optimize and evaluate self-assembled liquid crystalline nanoparticles (SALCs) prepared from phospholipids and oleic acid for enhancing the absorption of ω-3s. We explored the structure and optimal formulation of SALCs, which are composed of ω-3 ethyl ester (ω-3 EE), phospholipids, and oleic acid, using a ternary diagram and evaluated the improvement in ω-3 dissolution, permeation, and oral bioavailability. The in vitro dissolution and pharmacokinetics of ω-3 SALCs were compared with those of Omacor soft capsules (as the reference). The shape of the liquid crystal was determined according to the composition of phospholipids, oleic acids, and ω-3s and was found to be in cubic, lamellar, and hexagonal forms. The dissolution rates of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) obtained from ω-3 SALCs were 1.7 to 2.3-fold higher than those of the Omacor soft capsules. Furthermore, a pharmacokinetic study in male beagle dogs revealed that ω-3 SALCs increased the oral bioavailability of ω-3 EE by 2.5-fold for EPA and 3.1-fold for DHA compared with the reference. We found an optimal formulation that spontaneously forms liquid crystal-based nanoparticles, improving the bioavailability of EPA and DHA, not found in the existing literature. Our findings offer insight into the impact of nanoparticle phase on the oral delivery of oil-soluble drugs and provide a novel ω-3 EE formulation that improves the bioavailability of EPA and DHA.

Self-Assembled Geometric Liquid-Crystalline Nanoparticles Imaged in Three Dimensions:  Hexosomes Are Not Necessarily Flat Hexagonal Prisms

Langmuir ◽  
2007 ◽  
Vol 23 (25) ◽  
pp. 12461-12464 ◽  
Author(s):  
Ben J. Boyd ◽  
Shakila B. Rizwan ◽  
Yao-Da Dong ◽  
Sarah Hook ◽  
Thomas Rades
Keyword(s):  
Liquid Crystalline ◽  
Three Dimensions ◽  
Liquid Crystalline Nanoparticles ◽  
Self Assembled

scholarly journals Lipase Action on Self-Assembled Lipid Liquid Crystalline Nanoparticles

2011 ◽  
Vol 100 (3) ◽  
pp. 503a
Author(s):  
Justas Barauskas ◽  
Daniel Anderberg ◽  
Allan Svendsen ◽  
Tommy Nylander
Keyword(s):  
Liquid Crystalline ◽  
Liquid Crystalline Nanoparticles ◽  
Self Assembled

Nanostructure and cytotoxicity of self-assembled monoolein–capric acid lyotropic liquid crystalline nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (34) ◽  
pp. 26785-26795 ◽  
Author(s):  
Nhiem Tran ◽  
Xavier Mulet ◽  
Adrian M. Hawley ◽  
Tracey M. Hinton ◽  
Stephen T. Mudie ◽  
...  
Keyword(s):  
Liquid Crystalline ◽  
Capric Acid ◽  
Bicontinuous Cubic ◽  
Liquid Crystalline Nanoparticles ◽  
Self Assembled

Monoolein–capric acid combinations form into particles with internal nanostructures, including inverse hexagonal and bicontinuous cubic mesophases, with differing cytotoxicity.

Amphiphilic brush polymers produced using the RAFT polymerisation method stabilise and reduce the cell cytotoxicity of lipid lyotropic liquid crystalline nanoparticles

2016 ◽  
Vol 191 ◽  
pp. 545-563 ◽  
Author(s):  
Jiali Zhai ◽  
Randy Suryadinata ◽  
Bao Luan ◽  
Nhiem Tran ◽  
Tracey M. Hinton ◽  
...  
Keyword(s):  
Liquid Crystalline ◽  
Water Channel ◽  
Pluronic F127 ◽  
Cubic Phase ◽  
Valuable Insight ◽  
Liquid Crystalline Nanoparticles ◽  
Self Assembled ◽  
Poly Ethylene ◽  
Double Diamond

Self-assembled lipid lyotropic liquid crystalline nanoparticles such as hexosomes and cubosomes contain internal anisotropic and isotropic nanostructures, respectively. Despite the remarkable potential of such nanoparticles in various biomedical applications, the stabilisers used in formulating the nanoparticles are often limited to commercially available polymers such as the Pluronic block copolymers. This study explored the potential of using Reversible Addition-Fragmentation chain Transfer (RAFT) technology to design amphiphilic brush-type polymers for the purpose of stabilising phytantriol and monoolein-based lipid dispersions. The synthesised brush-type polymers consisted of a hydrophobic C12 short chain and a hydrophilic poly(ethylene glycol)methyl ether acrylate (PEGA) long chain with multiple 9-unit poly(ethylene oxide) (PEO) brushes with various molecular weights. It was observed that increasing the PEO brush density and thus the length of the hydrophilic component improved the stabilisation effectiveness for phytantriol and monoolein-based cubosomes. Synchrotron small-angle X-ray scattering (SAXS) experiments confirmed that the RAFT polymer-stabilised cubosomes had an internal double-diamond cubic phase with tunable water channel sizes. These properties were dependent on the molecular weight of the polymers, which were considered in some cases to be anisotropically distributed within the cubosomes. The in vitro toxicity of the cubosomes was assessed by cell viability of two human adenocarcinoma cell lines and haemolytic activities to mouse erythrocytes. The results showed that phytantriol cubosomes stabilised by the RAFT polymers were less toxic compared to their Pluronic F127-stabilised analogues. This study provides valuable insight into designing non-linear amphiphilic polymers for the effective stabilisation and cellular toxicity improvement of self-assembled lipid lyotropic liquid crystalline nanoparticles.

scholarly journals Quality by design (QbD) in the formulation and optimization of liquid crystalline nanoparticles (LCNPs): A risk based industrial approach

2021 ◽  
Vol 141 ◽  
pp. 111940
Author(s):  
Tejashree Waghule ◽  
Neha Dabholkar ◽  
Srividya Gorantla ◽  
Vamshi Krishna Rapalli ◽  
Ranendra Narayan Saha ◽  
...  
Keyword(s):  
Liquid Crystalline ◽  
Quality By Design ◽  
Liquid Crystalline Nanoparticles
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