One-step cross-linked injectable hydrogels with tunable properties for space-filling scaffolds in tissue engineering

RSC Advances ◽  
2015 ◽  
Vol 5 (51) ◽  
pp. 40820-40830 ◽  
Author(s):  
Jian-feng Pan ◽  
Heng-feng Yuan ◽  
Chang-an Guo ◽  
Jia Liu ◽  
Xiao-hua Geng ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Space Filling ◽  
Injectable Hydrogels ◽  
Tunable Properties ◽  
One Step

One-step cross-linked injectable hydrogels are prepared through Schiff-based reaction with tunable properties for space-filling scaffolds.

scholarly journals Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials?

2021 ◽  
Vol 22 (7) ◽  
pp. 3391
Author(s):  
Sylwia Grabska-Zielińska ◽  
Alina Sionkowska ◽  
Ewa Olewnik-Kruszkowska ◽  
Katarzyna Reczyńska ◽  
Elżbieta Pamuła
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Physicochemical Properties ◽  
Silk Fibroin ◽  
Three Dimensional ◽  
Microscopy Imaging ◽  
Maximum Deformation ◽  
One Step ◽  
Chitosan Blends ◽  
Fourier Transfer Infrared Spectroscopy

The aim of this work was to compare physicochemical properties of three dimensional scaffolds based on silk fibroin, collagen and chitosan blends, cross-linked with dialdehyde starch (DAS) and dialdehyde chitosan (DAC). DAS was commercially available, while DAC was obtained by one-step synthesis. Structure and physicochemical properties of the materials were characterized using Fourier transfer infrared spectroscopy with attenuated total reflectance device (FTIR-ATR), swelling behavior and water content measurements, porosity and density observations, scanning electron microscopy imaging (SEM), mechanical properties evaluation and thermogravimetric analysis. Metabolic activity with AlamarBlue assay and live/dead fluorescence staining were performed to evaluate the cytocompatibility of the obtained materials with MG-63 osteoblast-like cells. The results showed that the properties of the scaffolds based on silk fibroin, collagen and chitosan can be modified by chemical cross-linking with DAS and DAC. It was found that DAS and DAC have different influence on the properties of biopolymeric scaffolds. Materials cross-linked with DAS were characterized by higher swelling ability (~4000% for DAS cross-linked materials; ~2500% for DAC cross-linked materials), they had lower density (Coll/CTS/30SF scaffold cross-linked with DAS: 21.8 ± 2.4 g/cm3; cross-linked with DAC: 14.6 ± 0.7 g/cm3) and lower mechanical properties (maximum deformation for DAC cross-linked scaffolds was about 69%; for DAS cross-linked scaffolds it was in the range of 12.67 ± 1.51% and 19.83 ± 1.30%) in comparison to materials cross-linked with DAC. Additionally, scaffolds cross-linked with DAS exhibited higher biocompatibility than those cross-linked with DAC. However, the obtained results showed that both types of scaffolds can provide the support required in regenerative medicine and tissue engineering. The scaffolds presented in the present work can be potentially used in bone tissue engineering to facilitate healing of small bone defects.

scholarly journals Significance of Crosslinking Approaches in the Development of Next Generation Hydrogels for Corneal Tissue Engineering

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 319
Author(s):  
Promita Bhattacharjee ◽  
Mark Ahearne
Keyword(s):  
Tissue Engineering ◽  
Chemical Structure ◽  
Biochemical Properties ◽  
Corneal Tissue ◽  
Future Prospects ◽  
Chemical Additives ◽  
Injectable Hydrogels ◽  
Corneal Regeneration ◽  
Key Factor ◽  
Fuchs Endothelial Dystrophy

Medical conditions such as trachoma, keratoconus and Fuchs endothelial dystrophy can damage the cornea, leading to visual deterioration and blindness and necessitating a cornea transplant. Due to the shortage of donor corneas, hydrogels have been investigated as potential corneal replacements. A key factor that influences the physical and biochemical properties of these hydrogels is how they are crosslinked. In this paper, an overview is provided of different crosslinking techniques and crosslinking chemical additives that have been applied to hydrogels for the purposes of corneal tissue engineering, drug delivery or corneal repair. Factors that influence the success of a crosslinker are considered that include material composition, dosage, fabrication method, immunogenicity and toxicity. Different crosslinking techniques that have been used to develop injectable hydrogels for corneal regeneration are summarized. The limitations and future prospects of crosslinking strategies for use in corneal tissue engineering are discussed. It is demonstrated that the choice of crosslinking technique has a significant influence on the biocompatibility, mechanical properties and chemical structure of hydrogels that may be suitable for corneal tissue engineering and regenerative applications.

Self-assembly of Stimuli Responsive Coiled-coil Fibrous Hydrogels

Soft Matter ◽  
2021 ◽  
Author(s):  
Michael Meleties ◽  
Priya Katyal ◽  
Bonnie Lin ◽  
Dustin Britton ◽  
Jin Kim Montclare
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Coiled Coil ◽  
Stimuli Responsive ◽  
Tunable Properties ◽  
Stimuli Sensitive ◽  
Biomedical Fields

Owing to their tunable properties, hydrogels comprised of stimuli sensitive polymers are one of the most appealing scaffolds with applications in tissue engineering, drug delivery and other biomedical fields. We...

A Microfluidic Device to Fabricate One‐Step Cell Bead‐Laden Hydrogel Struts for Tissue Engineering

Small ◽  
2021 ◽  
pp. 2106487
Author(s):  
JuYeon Kim ◽  
Hyeongjin Lee ◽  
Eun‐Ju Jin ◽  
Yunju Jo ◽  
Baeki E. Kang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Microfluidic Device ◽  
One Step

Temperature- and pH-responsive chitosan-based injectable hydrogels for bone tissue engineering

2020 ◽  
Vol 111 ◽  
pp. 110862 ◽  
Author(s):  
K. Lavanya ◽  
S. Viji Chandran ◽  
K. Balagangadharan ◽  
N. Selvamurugan
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Ph Responsive ◽  
Injectable Hydrogels

Enzymatically-crosslinked injectable hydrogels based on biomimetic dextran–hyaluronic acid conjugates for cartilage tissue engineering

Biomaterials ◽  
2010 ◽  
Vol 31 (11) ◽  
pp. 3103-3113 ◽  
Author(s):  
R. Jin ◽  
L.S. Moreira Teixeira ◽  
P.J. Dijkstra ◽  
C.A. van Blitterswijk ◽  
M. Karperien ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Injectable Hydrogels

scholarly journals Injectable hydrogels for cartilage and bone tissue engineering

Bone Research ◽  
2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Mei Liu ◽  
Xin Zeng ◽  
Chao Ma ◽  
Huan Yi ◽  
Zeeshan Ali ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Injectable Hydrogels

scholarly journals Gellan Gum Injectable Hydrogels for Cartilage Tissue Engineering Applications: In Vitro Studies and Preliminary In Vivo Evaluation

2010 ◽  
Vol 16 (1) ◽  
pp. 343-353 ◽  
Author(s):  
João T. Oliveira ◽  
Tírcia C. Santos ◽  
Luís Martins ◽  
Ricardo Picciochi ◽  
Alexandra P. Marques ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Gellan Gum ◽  
In Vitro Studies ◽  
Cartilage Tissue ◽  
Engineering Applications ◽  
In Vivo Evaluation ◽  
Injectable Hydrogels

scholarly journals Structure–Property Evaluation of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering

2012 ◽  
Vol 13 (9) ◽  
pp. 2821-2830 ◽  
Author(s):  
Adam K. Ekenseair ◽  
Kristel W. M. Boere ◽  
Stephanie N. Tzouanas ◽  
Tiffany N. Vo ◽  
F. Kurtis Kasper ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Structure Property ◽  
Injectable Hydrogels ◽  
Property Evaluation
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