Roles of both amines and acid in supramolecular hydrogel formation of tetracarboxyl acid-appended calix[4]arene gelator

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 20066-20072 ◽  
Author(s):  
Heekyoung Choi ◽  
Ji Ha Lee ◽  
Jong Hwa Jung
Keyword(s):  
Tetracarboxylic Acid ◽  
Supramolecular Hydrogel ◽  
Arene Derivative ◽  
Hydrogel Formation

A tetracarboxylic acid-appended calix[4]arene derivative 1 which were insoluble in water could form a supramolecular hydrogel upon addition of both amines and HCl.

A colon-targeted podophyllotoxin nanoprodrug: synthesis, characterization, and supramolecular hydrogel formation for the drug combination

2021 ◽  
Vol 9 (14) ◽  
pp. 3200-3209
Author(s):  
Wei Ha ◽  
Xiao-Bo Zhao ◽  
Wei-Hua Zhao ◽  
Jiang-Jiang Tang ◽  
Yan-Ping Shi
Keyword(s):  
Self Assembly ◽  
Drug Combination ◽  
Therapeutic Agents ◽  
Supramolecular Hydrogel ◽  
Assembly Strategy ◽  
Hydrogel Formation

An ingeniously designed podophyllotoxin nanoprodrug was synthesized and offered an effective platform for co-delivery of multiple therapeutic agents for drug combination via the hierarchical self-assembly strategy.

Supramolecular Hydrogel Formation in a Series of Self-Assembling Lipopeptides with Varying Lipid Chain Length

2017 ◽  
Vol 18 (7) ◽  
pp. 2013-2023 ◽  
Author(s):  
V. Castelletto ◽  
A. Kaur ◽  
R. M. Kowalczyk ◽  
I. W. Hamley ◽  
M. Reza ◽  
...  
Keyword(s):  
Chain Length ◽  
Supramolecular Hydrogel ◽  
Self Assembling ◽  
Hydrogel Formation ◽  
Lipid Chain

scholarly journals Development of an Amino Sugar-Based Supramolecular Hydrogelator with Reduction Responsiveness

2021 ◽  
Author(s):  
Sayuri L. Higashi ◽  
Masato Ikeda
Keyword(s):  
Molecular Weight ◽  
Molecular Design ◽  
Soft Materials ◽  
Amino Sugar ◽  
Low Molecular Weight ◽  
Stimuli Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembling ◽  
Hydrogel Formation

Stimuli-responsive supramolecular hydrogels are a newly emerging class of aqueous soft materials with a wide variety of bioapplications. Here we report a reduction-responsive supramolecular hydrogel constructed from a markedly simple low-molecular-weight hydrogelator, which is developed on the basis of modular molecular design containing a hydrophilic amino sugar and a reduction-responsive nitrophenyl group. The hydrogel formation ability differs significantly between glucosamine- and galactosamine-based self-assembling molecules, which are epimers at the C4 position, and only the glucosamine-based derivative can act as a hydrogelator.

Supramolecular Hydrogel Formation Based on Tannic Acid

2017 ◽  
Vol 50 (2) ◽  
pp. 666-676 ◽  
Author(s):  
Hailong Fan ◽  
Le Wang ◽  
Xunda Feng ◽  
Yazhong Bu ◽  
Decheng Wu ◽  
...  
Keyword(s):  
Tannic Acid ◽  
Supramolecular Hydrogel ◽  
Hydrogel Formation

Negatively Charged Lipid Membranes Catalyze Supramolecular Hydrogel Formation

2016 ◽  
Vol 138 (28) ◽  
pp. 8670-8673 ◽  
Author(s):  
Frank Versluis ◽  
Daphne M. van Elsland ◽  
Serhii Mytnyk ◽  
Dayinta L. Perrier ◽  
Fanny Trausel ◽  
...  
Keyword(s):  
Lipid Membranes ◽  
Supramolecular Hydrogel ◽  
Hydrogel Formation

scholarly journals Development of an Amino Sugar-Based Supramolecular Hydrogelator with Reduction Responsiveness

2021 ◽  
Author(s):  
Sayuri L. Higashi ◽  
Masato Ikeda
Keyword(s):  
Molecular Weight ◽  
Molecular Design ◽  
Soft Materials ◽  
Amino Sugar ◽  
Low Molecular Weight ◽  
Stimuli Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembling ◽  
Hydrogel Formation

Stimuli-responsive supramolecular hydrogels are a newly emerging class of aqueous soft materials with a wide variety of bioapplications. Here we report a reduction-responsive supramolecular hydrogel constructed from a markedly simple low-molecular-weight hydrogelator, which is developed on the basis of modular molecular design containing a hydrophilic amino sugar and a reduction-responsive nitrophenyl group. The hydrogel formation ability differs significantly between glucosamine- and galactosamine-based self-assembling molecules, which are epimers at the C4 position, and only the glucosamine-based derivative can act as a hydrogelator.

Chemical stimulus-responsive supramolecular hydrogel formation and shrinkage of a hydrazone-containing short peptide derivative

Soft Matter ◽  
2020 ◽  
Vol 16 (4) ◽  
pp. 899-906 ◽  
Author(s):  
Takumi Sugiura ◽  
Takurou Kanada ◽  
Daisuke Mori ◽  
Hiroyuki Sakai ◽  
Aya Shibata ◽  
...  
Keyword(s):  
Exchange Reaction ◽  
Chemical Stimulus ◽  
Supramolecular Hydrogel ◽  
Short Peptide ◽  
Hydrazone Bond ◽  
Stimulus Responsive ◽  
Hydrogel Formation ◽  
Peptide Derivative

Herein, we describe a short peptide derivative containing a hydrazone bond showing transient hydrogel formation triggered by hydrazone–oxime exchange reaction.

scholarly journals Ultrasound-Induced Amino Acid-Based Hydrogels With Superior Mechanical Strength for Controllable Long-Term Release of Anti-Cercariae Drug

2021 ◽  
Vol 9 ◽  
Author(s):  
Liying Ling ◽  
Lei Zhu ◽  
Yibao Li ◽  
Chunhua Liu ◽  
Linxiu Cheng
Keyword(s):  
Drug Release ◽  
Slow Release ◽  
Superior Performance ◽  
Cytotoxicity Test ◽  
Tetracarboxylic Acid ◽  
Supramolecular Hydrogel ◽  
Stimulus Responsive ◽  
Potential Applications ◽  
Responsive Hydrogels

Stimulus-responsive hydrogels are significantly programmable materials that show potential applications in the field of biomedicine and the environment. Ultrasound as a stimulus can induce the formation of hydrogels, which exhibit the superior performance of different structures. In this study, we reported an ultrasound-induced supramolecular hydrogel based on aspartic acid derivative N,N′-diaspartate-3,4,9,10-perylene tetracarboxylic acid imide, showing superior performance in drug release. The results show that the driving force of this ultrasonic induced hydrogel could be attributed to hydrogen bonding and π-π interaction. The rheological and cytotoxicity test illustrate excellent mechanical properties and biocompatibility of the hydrogel. The anti-Schistosoma japonicum cercariae (CC) drug release results show large drug loadings (500 mg/ml) and long-term release (15 days) of this hydrogel. This study demonstrates that this hydrogel may serve as a slow-release platform for anti-CC.

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