Negatively Charged Lipid Membranes Catalyze Supramolecular Hydrogel Formation

2016 ◽  
Vol 138 (28) ◽  
pp. 8670-8673 ◽  
Author(s):  
Frank Versluis ◽  
Daphne M. van Elsland ◽  
Serhii Mytnyk ◽  
Dayinta L. Perrier ◽  
Fanny Trausel ◽  
...  
Keyword(s):  
Lipid Membranes ◽  
Supramolecular Hydrogel ◽  
Hydrogel Formation

A colon-targeted podophyllotoxin nanoprodrug: synthesis, characterization, and supramolecular hydrogel formation for the drug combination

2021 ◽  
Vol 9 (14) ◽  
pp. 3200-3209
Author(s):  
Wei Ha ◽  
Xiao-Bo Zhao ◽  
Wei-Hua Zhao ◽  
Jiang-Jiang Tang ◽  
Yan-Ping Shi
Keyword(s):  
Self Assembly ◽  
Drug Combination ◽  
Therapeutic Agents ◽  
Supramolecular Hydrogel ◽  
Assembly Strategy ◽  
Hydrogel Formation

An ingeniously designed podophyllotoxin nanoprodrug was synthesized and offered an effective platform for co-delivery of multiple therapeutic agents for drug combination via the hierarchical self-assembly strategy.

Supramolecular Hydrogel Formation in a Series of Self-Assembling Lipopeptides with Varying Lipid Chain Length

2017 ◽  
Vol 18 (7) ◽  
pp. 2013-2023 ◽  
Author(s):  
V. Castelletto ◽  
A. Kaur ◽  
R. M. Kowalczyk ◽  
I. W. Hamley ◽  
M. Reza ◽  
...  
Keyword(s):  
Chain Length ◽  
Supramolecular Hydrogel ◽  
Self Assembling ◽  
Hydrogel Formation ◽  
Lipid Chain

scholarly journals Development of an Amino Sugar-Based Supramolecular Hydrogelator with Reduction Responsiveness

2021 ◽  
Author(s):  
Sayuri L. Higashi ◽  
Masato Ikeda
Keyword(s):  
Molecular Weight ◽  
Molecular Design ◽  
Soft Materials ◽  
Amino Sugar ◽  
Low Molecular Weight ◽  
Stimuli Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembling ◽  
Hydrogel Formation

Stimuli-responsive supramolecular hydrogels are a newly emerging class of aqueous soft materials with a wide variety of bioapplications. Here we report a reduction-responsive supramolecular hydrogel constructed from a markedly simple low-molecular-weight hydrogelator, which is developed on the basis of modular molecular design containing a hydrophilic amino sugar and a reduction-responsive nitrophenyl group. The hydrogel formation ability differs significantly between glucosamine- and galactosamine-based self-assembling molecules, which are epimers at the C4 position, and only the glucosamine-based derivative can act as a hydrogelator.

Roles of both amines and acid in supramolecular hydrogel formation of tetracarboxyl acid-appended calix[4]arene gelator

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 20066-20072 ◽  
Author(s):  
Heekyoung Choi ◽  
Ji Ha Lee ◽  
Jong Hwa Jung
Keyword(s):  
Tetracarboxylic Acid ◽  
Supramolecular Hydrogel ◽  
Arene Derivative ◽  
Hydrogel Formation

A tetracarboxylic acid-appended calix[4]arene derivative 1 which were insoluble in water could form a supramolecular hydrogel upon addition of both amines and HCl.

Supramolecular Hydrogel Formation Based on Tannic Acid

2017 ◽  
Vol 50 (2) ◽  
pp. 666-676 ◽  
Author(s):  
Hailong Fan ◽  
Le Wang ◽  
Xunda Feng ◽  
Yazhong Bu ◽  
Decheng Wu ◽  
...  
Keyword(s):  
Tannic Acid ◽  
Supramolecular Hydrogel ◽  
Hydrogel Formation

scholarly journals Development of an Amino Sugar-Based Supramolecular Hydrogelator with Reduction Responsiveness

2021 ◽  
Author(s):  
Sayuri L. Higashi ◽  
Masato Ikeda
Keyword(s):  
Molecular Weight ◽  
Molecular Design ◽  
Soft Materials ◽  
Amino Sugar ◽  
Low Molecular Weight ◽  
Stimuli Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembling ◽  
Hydrogel Formation

Stimuli-responsive supramolecular hydrogels are a newly emerging class of aqueous soft materials with a wide variety of bioapplications. Here we report a reduction-responsive supramolecular hydrogel constructed from a markedly simple low-molecular-weight hydrogelator, which is developed on the basis of modular molecular design containing a hydrophilic amino sugar and a reduction-responsive nitrophenyl group. The hydrogel formation ability differs significantly between glucosamine- and galactosamine-based self-assembling molecules, which are epimers at the C4 position, and only the glucosamine-based derivative can act as a hydrogelator.

Chemical stimulus-responsive supramolecular hydrogel formation and shrinkage of a hydrazone-containing short peptide derivative

Soft Matter ◽  
2020 ◽  
Vol 16 (4) ◽  
pp. 899-906 ◽  
Author(s):  
Takumi Sugiura ◽  
Takurou Kanada ◽  
Daisuke Mori ◽  
Hiroyuki Sakai ◽  
Aya Shibata ◽  
...  
Keyword(s):  
Exchange Reaction ◽  
Chemical Stimulus ◽  
Supramolecular Hydrogel ◽  
Short Peptide ◽  
Hydrazone Bond ◽  
Stimulus Responsive ◽  
Hydrogel Formation ◽  
Peptide Derivative

Herein, we describe a short peptide derivative containing a hydrazone bond showing transient hydrogel formation triggered by hydrazone–oxime exchange reaction.

Redox Reactions in Lipid Membranes as a Model for Primordial Energy-Conserving Systems

1997 ◽  
Vol 161 ◽  
pp. 437-442
Author(s):  
Salvatore Di Bernardo ◽  
Romana Fato ◽  
Giorgio Lenaz
Keyword(s):  
Experimental Evidence ◽  
Lipid Membranes ◽  
Energy Supply ◽  
Redox Reactions ◽  
Living Systems ◽  
Asymmetric Distribution ◽  
Conservation Of Energy ◽  
Asymmetrical Distribution ◽  
Energy Conserving ◽  
Living Organisms

AbstractOne of the peculiar aspects of living systems is the production and conservation of energy. This aspect is provided by specialized organelles, such as the mitochondria and chloroplasts, in developed living organisms. In primordial systems lacking specialized enzymatic complexes the energy supply was probably bound to the generation and maintenance of an asymmetric distribution of charged molecules in compartmentalized systems. On the basis of experimental evidence, we suggest that lipophilic quinones were involved in the generation of this asymmetrical distribution of charges through vectorial redox reactions across lipid membranes.

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