Multi-stimuli responsive supramolecular hydrogels based on Fe3+ and diblock copolymer micelle complexation

2016 ◽  
Vol 7 (7) ◽  
pp. 1405-1412 ◽  
Author(s):  
Zhen Tao ◽  
Kang Peng ◽  
Yujiao Fan ◽  
Yunfei Liu ◽  
Haiyang Yang
Keyword(s):  
Carboxylic Acid ◽  
Uv Irradiation ◽  
Diblock Copolymer ◽  
Biomedical Application ◽  
Stimuli Responsive ◽  
Ferric Ions ◽  
Supramolecular Hydrogel ◽  
Carboxylic Acid Groups ◽  
Copolymer Micelle ◽  
Redox Agents

We report a multi-stimuli responsive supramolecular hydrogel with great potential for biomedical application, which was composed of the micelle-forming diblock copolymer and physically cross-linked by complexation between ferric ions and carboxylic acid groups, exhibiting gel–sol transition caused by UV irradiation, multidentate ligands (EDTA) and redox agents (Na2S2O4).

scholarly journals Controlled Ring-Opening Polymerization of N-(3-tert-Butoxy-3-oxopropyl) Glycine Derived N-Carboxyanhydrides towards Well-defined Peptoid-based Polyacids

2021 ◽  
Author(s):  
Donghui Zhang ◽  
Bailee Barrett ◽  
Garrett Sternhagen
Keyword(s):  
Carboxylic Acid ◽  
Ring Opening ◽  
Building Blocks ◽  
Ring Opening Polymerization ◽  
Supramolecular Assemblies ◽  
Stimuli Responsive ◽  
Carboxylic Acid Groups

Polypeptoids bearing carboxylic acid groups on the N-substituent are useful building blocks for the construction of peptidomimetic supramolecular assemblies with stimuli-responsive properties. Towards this end, N-(3-tert-butoxy-3-oxopropyl) glycine derived N-carboxyanhydride (tBuO2Pr-NCA)...

scholarly journals Grafting TRAIL through Either Amino or Carboxylic Groups onto Maghemite Nanoparticles: Influence on Pro-Apoptotic Efficiency

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 502
Author(s):  
Hanene Belkahla ◽  
Andrei Alexandru Constantinescu ◽  
Tijani Gharbi ◽  
Florent Barbault ◽  
Alexandre Chevillot-Biraud ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Cancer Therapy ◽  
Computational Study ◽  
Carcinoma Cells ◽  
Maghemite Nanoparticles ◽  
Carboxylic Acid Groups ◽  
Lung Carcinoma Cells ◽  
Biological Studies ◽  
Apoptotic Effect ◽  
Carboxylic Groups

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF cytokine superfamily. TRAIL is able to induce apoptosis through engagement of its death receptors DR4 and DR5 in a wide variety of tumor cells while sparing vital normal cells. This makes it a promising agent for cancer therapy. Here, we present two different ways of covalently grafting TRAIL onto maghemite nanoparticles (NPs): (a) by using carboxylic acid groups of the protein to graft it onto maghemite NPs previously functionalized with amino groups, and (b) by using the amino functions of the protein to graft it onto NPs functionalized with carboxylic acid groups. The two resulting nanovectors, NH-TRAIL@NPs-CO and CO-TRAIL@NPs-NH, were thoroughly characterized. Biological studies performed on human breast and lung carcinoma cells (MDA-MB-231 and H1703 cell lines) established these nanovectors are potential agents for cancer therapy. The pro-apoptotic effect is somewhat greater for CO-TRAIL@NPs-NH than NH-TRAIL@NPs-CO, as evidenced by viability studies and apoptosis analysis. A computational study indicated that regardless of whether TRAIL is attached to NPs through an acid or an amino group, DR4 recognition is not affected in either case.

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

Dual-temperature and pH responsive (ethylene glycol)-based nanogels via structural design

2014 ◽  
Vol 5 (8) ◽  
pp. 3061-3070 ◽  
Author(s):  
Yohei Kotsuchibashi ◽  
Ravin Narain
Keyword(s):  
Carboxylic Acid ◽  
Ethylene Glycol ◽  
Salt Concentration ◽  
Structural Design ◽  
Solution Temperature ◽  
Ph Responsive ◽  
Solution Ph ◽  
Critical Solution Temperature ◽  
Carboxylic Acid Groups ◽  
The Core

Dual-temperature and pH responsive (ethylene glycol)-based nanogels were synthesized. Both the core and the shell of the nanogels showed a lower critical solution temperature (LCST) and the LCST of the shell was strongly affected by the solution pH and salt concentration due to the presence of carboxylic acid groups at the nanogel surface.

Metal ion retention properties of water-insoluble polymers containing carboxylic acid groups

2005 ◽  
Vol 99 (3) ◽  
pp. 697-705 ◽  
Author(s):  
Bernabé L. Rivas ◽  
Benita Quilodrán ◽  
Eduardo Quiroz
Keyword(s):  
Carboxylic Acid ◽  
Metal Ion ◽  
Carboxylic Acid Groups ◽  
Insoluble Polymers

Stabilization of perfluoropolyethers (PFPEs) with acyl fluoride and carboxylic acid end-groups by UV-irradiation

2019 ◽  
Vol 156 ◽  
pp. 44-49 ◽  
Author(s):  
Saurabh Saxena ◽  
Prateek Malik ◽  
Ajay K. Tyagi ◽  
Geetha Seshadri ◽  
Uttam Kumar Mandal
Keyword(s):  
Carboxylic Acid ◽  
Uv Irradiation ◽  
End Groups

Oxidation of poly[bis(4-methylphenoxy)phosphazene] surfaces and chemistry of the surface carboxylic acid groups

1992 ◽  
Vol 4 (4) ◽  
pp. 769-775 ◽  
Author(s):  
Harry R. Allcock ◽  
Richard J. Fitzpatrick ◽  
Lawrence Salvati
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acid Groups

Direct synthesis of ordered and highly functionalized organosilicas containing carboxylic acid groups

2007 ◽  
Vol 17 (7) ◽  
pp. 616 ◽  
Author(s):  
Rola Mouawia ◽  
Ahmad Mehdi ◽  
Catherine Rey? ◽  
Robert Corriu
Keyword(s):  
Carboxylic Acid ◽  
Direct Synthesis ◽  
Carboxylic Acid Groups
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