Dual-temperature and pH responsive (ethylene glycol)-based nanogels via structural design

2014 ◽  
Vol 5 (8) ◽  
pp. 3061-3070 ◽  
Author(s):  
Yohei Kotsuchibashi ◽  
Ravin Narain
Keyword(s):  
Carboxylic Acid ◽  
Ethylene Glycol ◽  
Salt Concentration ◽  
Structural Design ◽  
Solution Temperature ◽  
Ph Responsive ◽  
Solution Ph ◽  
Critical Solution Temperature ◽  
Carboxylic Acid Groups ◽  
The Core

Dual-temperature and pH responsive (ethylene glycol)-based nanogels were synthesized. Both the core and the shell of the nanogels showed a lower critical solution temperature (LCST) and the LCST of the shell was strongly affected by the solution pH and salt concentration due to the presence of carboxylic acid groups at the nanogel surface.

scholarly journals Modulating the Thermoresponse of Polymer-Protein Conjugates with Hydrogels for Controlled Release

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2772
Author(s):  
Vincent Huynh ◽  
Natalie Ifraimov ◽  
Ryan G. Wylie
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Ethylene Glycol ◽  
Solution Temperature ◽  
Residence Times ◽  
Release Rates ◽  
Critical Solution Temperature ◽  
Protein Conjugates ◽  
Particle Encapsulation ◽  
Glycol Methyl Ether

Sustained release is being explored to increase plasma and tissue residence times of polymer-protein therapeutics for improved efficacy. Recently, poly(oligo(ethylene glycol) methyl ether methacrylate) (PEGMA) polymers have been established as potential PEG alternatives to further decrease immunogenicity and introduce responsive or sieving properties. We developed a drug delivery system that locally depresses the lower critical solution temperature (LCST) of PEGMA-protein conjugates within zwitterionic hydrogels for controlled release. Inside the hydrogel the conjugates partially aggregate through PEGMA-PEGMA chain interactions to limit their release rates, whereas conjugates outside of the hydrogel are completely solubilized. Release can therefore be tuned by altering hydrogel components and the PEGMA’s temperature sensitivity without the need for traditional controlled release mechanisms such as particle encapsulation or affinity interactions. Combining local LCST depression technology and degradable zwitterionic hydrogels, complete release of the conjugate was achieved over 13 days.

scholarly journals Smart, Naturally-Derived Macromolecules for Controlled Drug Release

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1918
Author(s):  
Izabela Zaborniak ◽  
Angelika Macior ◽  
Paweł Chmielarz
Keyword(s):  
Smart Materials ◽  
Phase Transfer ◽  
Controlled Drug Release ◽  
Polymer Chains ◽  
Solution Temperature ◽  
Hydrodynamic Diameter ◽  
Ph Responsive ◽  
Critical Solution Temperature ◽  
Vis Spectroscopy ◽  
Responsive Behavior

A series of troxerutin-based macromolecules with ten poly(acrylic acid) (PAA) or poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) homopolymer side chains were synthesized by a supplemental activator and reducing agent atom transfer radical polymerization (SARA ATRP) approach. The prepared precisely-defined structures with low dispersity (Mw/Mn < 1.09 for PAA-based, and Mw/Mn < 1.71 for PDMAEMA-based macromolecules) exhibited pH-responsive behavior depending on the length of the polymer grafts. The properties of the received polyelectrolytes were investigated by dynamic light scattering (DLS) measurement to determine the hydrodynamic diameter and zeta potential upon pH changes. Additionally, PDMAEMA-based polymers showed thermoresponsive properties and exhibited phase transfer at a lower critical solution temperature (LCST). Thanks to polyelectrolyte characteristics, the prepared polymers were investigated as smart materials for controlled release of quercetin. The influence of the length of the polymer grafts for the quercetin release profile was examined by UV–VIS spectroscopy. The results suggest the strong correlation between the length of the polymer chains and the efficiency of active substance release, thus, the adjustment of the composition of the macromolecules characterized by branched architecture can precisely control the properties of smart delivery systems.

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