RAFT polymerization of ciprofloxacin prodrug monomers for the controlled intracellular delivery of antibiotics

2016 ◽  
Vol 7 (4) ◽  
pp. 826-837 ◽  
Author(s):  
Debobrato Das ◽  
Selvi Srinivasan ◽  
Abby M. Kelly ◽  
David Y. Chiu ◽  
Bridget K. Daugherty ◽  
...  
Keyword(s):  
Raft Polymerization ◽  
Intracellular Delivery ◽  
Methacrylate Group ◽  
Aliphatic Esters

Prodrug monomers derived from the antibiotic ciprofloxacin were synthesized with phenolic or aliphatic esters linking the drug to a polymerizable methacrylate group.

scholarly journals A new proton sponge polymer synthesized by RAFT polymerization for intracellular delivery of biotherapeutics

2014 ◽  
Vol 5 (5) ◽  
pp. 1593-1604 ◽  
Author(s):  
Isil Kurtulus ◽  
Gokhan Yilmaz ◽  
Muhammed Ucuncu ◽  
Mustafa Emrullahoglu ◽  
C. Remzi Becer ◽  
...  
Keyword(s):  
Raft Polymerization ◽  
Intracellular Delivery ◽  
Proton Sponge

Synthesis of Zwitterionic Chimeric Polymersomes for Efficient Protein Loading and Intracellular Delivery

2021 ◽  
Author(s):  
bingbing zhao ◽  
Yuting Yan ◽  
Junmei Zhang ◽  
Enping Chen ◽  
Ke Wang ◽  
...  
Keyword(s):  
Ring Opening ◽  
Triblock Copolymer ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Intracellular Delivery ◽  
Ring Opening Polymerization ◽  
H Nmr ◽  
Protein Loading ◽  
Reversible Addition

A novel zwitterionic triblock copolymer of poly(dimethylamino carbonate)-polycaprolactone-poly((2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium) [PAC(DMA)-PCL-PMDMSA] was designed and synthesized via sequential ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer (RAFT) polymerization successively. The 1H NMR and...

Probing Cellular Outcomes Using Heterobivalent Constructs

2019 ◽  
Author(s):  
Rohit Bhadoria ◽  
Kefeng Ping ◽  
Christer Lohk ◽  
Ivar Järving ◽  
Pavel Starkov
Keyword(s):  
Cell Viability ◽  
Small Molecules ◽  
Cellular Uptake ◽  
Kinase Inhibitors ◽  
Rho Kinase ◽  
Intracellular Delivery ◽  
Rho Kinase Inhibitors

<div> <div> <div> <p>Conjugation techniques are central to improving intracellular delivery of bioactive small molecules. However, tracking and assessing the overall biological outcome of these constructs remains poorly understood. We addressed this issue by having developed a focused library of heterobivalent constructs based on Rho kinase inhibitors to probe various scenarios. By comparing induction of a phenotype of interest vs. cell viability vs. cellular uptake, we demonstrate that such conjugates indeed lead to divergent cellular outcomes. </p> </div> </div> </div>

Intracellular Delivery of Nanocarriers for Cancer Therapy

2007 ◽  
Vol 3 (4) ◽  
pp. 329-338 ◽  
Author(s):  
Yah-el Har-el ◽  
Yoshinori Kato
Keyword(s):  
Cancer Therapy ◽  
Intracellular Delivery

Mesomorphic Behaviour of Saturated and Monounsaturated C18 and C22 Fatty Acid Esters of Cholesterol

1994 ◽  
Vol 59 (4) ◽  
pp. 833-840
Author(s):  
Slavomír Pirkl
Keyword(s):  
Phase Transitions ◽  
Fatty Acid ◽  
Fatty Acid Esters ◽  
Aliphatic Esters ◽  
Acid Esters

The phase transitions and effective optical rotary power of saturated and monounsaturated aliphatic esters of cholesterol with 18 and 22 carbon atoms in the chain have been described. The effect of cis/trans isomerism on these properties is discussed.

Investigation of novel diethanolamine dithiocarbamate agent for RAFT polymerization: DFT computational study of the oligomer molecules

2021 ◽  
Vol 44 (3) ◽  
Author(s):  
Ümİt Yİldİko ◽  
Ahmet Çağri Ata ◽  
Aslihan Aycan Tanriverdİ ◽  
İsmaİl Çakmak
Keyword(s):  
Computational Study ◽  
Raft Polymerization
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