scholarly journals A new proton sponge polymer synthesized by RAFT polymerization for intracellular delivery of biotherapeutics

2014 ◽  
Vol 5 (5) ◽  
pp. 1593-1604 ◽  
Author(s):  
Isil Kurtulus ◽  
Gokhan Yilmaz ◽  
Muhammed Ucuncu ◽  
Mustafa Emrullahoglu ◽  
C. Remzi Becer ◽  
...  
Keyword(s):  
Raft Polymerization ◽  
Intracellular Delivery ◽  
Proton Sponge

Synthesis of Zwitterionic Chimeric Polymersomes for Efficient Protein Loading and Intracellular Delivery

2021 ◽  
Author(s):  
bingbing zhao ◽  
Yuting Yan ◽  
Junmei Zhang ◽  
Enping Chen ◽  
Ke Wang ◽  
...  
Keyword(s):  
Ring Opening ◽  
Triblock Copolymer ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Intracellular Delivery ◽  
Ring Opening Polymerization ◽  
H Nmr ◽  
Protein Loading ◽  
Reversible Addition

A novel zwitterionic triblock copolymer of poly(dimethylamino carbonate)-polycaprolactone-poly((2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium) [PAC(DMA)-PCL-PMDMSA] was designed and synthesized via sequential ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer (RAFT) polymerization successively. The 1H NMR and...

RAFT polymerization of ciprofloxacin prodrug monomers for the controlled intracellular delivery of antibiotics

2016 ◽  
Vol 7 (4) ◽  
pp. 826-837 ◽  
Author(s):  
Debobrato Das ◽  
Selvi Srinivasan ◽  
Abby M. Kelly ◽  
David Y. Chiu ◽  
Bridget K. Daugherty ◽  
...  
Keyword(s):  
Raft Polymerization ◽  
Intracellular Delivery ◽  
Methacrylate Group ◽  
Aliphatic Esters

Prodrug monomers derived from the antibiotic ciprofloxacin were synthesized with phenolic or aliphatic esters linking the drug to a polymerizable methacrylate group.

Probing Cellular Outcomes Using Heterobivalent Constructs

2019 ◽  
Author(s):  
Rohit Bhadoria ◽  
Kefeng Ping ◽  
Christer Lohk ◽  
Ivar Järving ◽  
Pavel Starkov
Keyword(s):  
Cell Viability ◽  
Small Molecules ◽  
Cellular Uptake ◽  
Kinase Inhibitors ◽  
Rho Kinase ◽  
Intracellular Delivery ◽  
Rho Kinase Inhibitors

<div> <div> <div> <p>Conjugation techniques are central to improving intracellular delivery of bioactive small molecules. However, tracking and assessing the overall biological outcome of these constructs remains poorly understood. We addressed this issue by having developed a focused library of heterobivalent constructs based on Rho kinase inhibitors to probe various scenarios. By comparing induction of a phenotype of interest vs. cell viability vs. cellular uptake, we demonstrate that such conjugates indeed lead to divergent cellular outcomes. </p> </div> </div> </div>

Intracellular Delivery of Nanocarriers for Cancer Therapy

2007 ◽  
Vol 3 (4) ◽  
pp. 329-338 ◽  
Author(s):  
Yah-el Har-el ◽  
Yoshinori Kato
Keyword(s):  
Cancer Therapy ◽  
Intracellular Delivery
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