Polypeptide–poly(ethylene glycol) miktoarm star copolymers with a fluorescently labeled core: synthesis, delivery and imaging of siRNA

2016 ◽  
Vol 7 (9) ◽  
pp. 1792-1802 ◽  
Author(s):  
Jianbing Huang ◽  
Hui Liang ◽  
Du Cheng ◽  
Jiang Lu
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Star Copolymers ◽  
Miktoarm Star ◽  
Poly Ethylene ◽  
Dual Functions

Polypeptide–PEG miktoarm star copolymers with a fluorescently labeled core have been synthesized and exhibit dual functions of gene delivery and bioimaging.

Synthesis and pyrolysis of ABC type miktoarm star copolymers with polystyrene, poly(lactic acid) and poly(ethylene glycol) arms

2012 ◽  
Vol 48 (10) ◽  
pp. 1755-1767 ◽  
Author(s):  
Suriye Ozlem ◽  
Birol Iskin ◽  
Gorkem Yilmaz ◽  
Manolya Kukut ◽  
Jale Hacaloglu ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Star Copolymers ◽  
Miktoarm Star ◽  
Poly Ethylene

Synthesis of Amphiphilic Miktoarm Star Copolymers of Poly(n-hexyl isocyanate) and Poly(ethylene glycol) through Reaction with the Active Methylene Group

2008 ◽  
Vol 41 (19) ◽  
pp. 7029-7032 ◽  
Author(s):  
M. Shahinur Rahman ◽  
Mohammad Changez ◽  
Jin-Wook Yoo ◽  
Chi H. Lee ◽  
Shashadhar Samal ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Star Copolymers ◽  
Miktoarm Star ◽  
Poly Ethylene ◽  
Active Methylene ◽  
Methylene Group

AB2 Y-shaped miktoarm star conductive polyaniline-modified poly(ethylene glycol) and its electrospun nanofiber blend with poly(ε-caprolactone)

RSC Advances ◽  
2015 ◽  
Vol 5 (46) ◽  
pp. 36715-36726 ◽  
Author(s):  
Bakhshali Massoumi ◽  
Somayeh Davtalab ◽  
Mehdi Jaymand ◽  
Ali Akbar Entezami
Keyword(s):  
Ethylene Glycol ◽  
Electrospun Nanofibers ◽  
Synthesis And Characterization ◽  
Electrospun Nanofiber ◽  
Poly Ethylene Glycol ◽  
Conductive Polyaniline ◽  
Miktoarm Star ◽  
Poly Ethylene ◽  
Type Ab

The aim of this study is the synthesis, and characterization of novel type AB2 Y-shaped miktoarm star conductive polyaniline-modified poly(ethylene glycol), and preparation of its electrospun nanofibers blend with poly(ε-caprolactone).

Cationic long-chain hyperbranched poly(ethylene glycol)s with low charge density for gene delivery

2013 ◽  
Vol 4 (2) ◽  
pp. 393-401 ◽  
Author(s):  
Chunlai Tu ◽  
Nan Li ◽  
Lijuan Zhu ◽  
Linzhu Zhou ◽  
Yue Su ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Charge Density ◽  
Poly Ethylene Glycol ◽  
Hyperbranched Poly ◽  
Poly Ethylene ◽  
Low Charge ◽  
Long Chain

scholarly journals The Importance of Poly(ethylene glycol) and Lipid Structure in Targeted Gene Delivery to Lymph Nodes by Lipid Nanoparticles

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1068 ◽  
Author(s):  
Danijela Zukancic ◽  
Estelle J. A. Suys ◽  
Emily H. Pilkington ◽  
Azizah Algarni ◽  
Hareth Al-Wassiti ◽  
...  
Keyword(s):  
Lymph Node ◽  
Gene Delivery ◽  
Ethylene Glycol ◽  
Lymph Nodes ◽  
Injection Site ◽  
Targeted Delivery ◽  
Lipid Nanoparticles ◽  
Tween 20 ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Targeted delivery of nucleic acids to lymph nodes is critical for the development of effective vaccines and immunotherapies. However, it remains challenging to achieve selective lymph node delivery. Current gene delivery systems target mainly to the liver and typically exhibit off-target transfection at various tissues. Here we report novel lipid nanoparticles (LNPs) that can deliver plasmid DNA (pDNA) to a draining lymph node, thereby significantly enhancing transfection at this target organ, and substantially reducing gene expression at the intramuscular injection site (muscle). In particular, we discovered that LNPs stabilized by 3% Tween 20, a surfactant with a branched poly(ethylene glycol) (PEG) chain linking to a short lipid tail, achieved highly specific transfection at the lymph node. This was in contrast to conventional LNPs stabilized with a linear PEG chain and two saturated lipid tails (PEG-DSPE) that predominately transfected at the injection site (muscle). Interestingly, replacing Tween 20 with Tween 80, which has a longer unsaturated lipid tail, led to a much lower transfection efficiency. Our work demonstrates the importance of PEGylation in selective organ targeting of nanoparticles, provides new insights into the structure–property relationship of LNPs, and offers a novel, simple, and practical PEGylation technology to prepare the next generation of safe and effective vaccines against viruses or tumours.

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