Efficient cancer cell capturing SiNWAs prepared via surface-initiated SET-LRP and click chemistry

2015 ◽  
Vol 6 (19) ◽  
pp. 3708-3715 ◽  
Author(s):  
Lulu Xue ◽  
Zhonglin Lyu ◽  
Yafei Luan ◽  
Xinhong Xiong ◽  
Jingjing Pan ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Cancer Cell ◽  
Specific Cancer

Enhanced specific cancer cell capturing effect generated by combining a glycopolymer and aptamer through SI-SET-LRP and click chemistry.

Light-Triggered Specific Cancer Cell Release from Cyclodextrin/Azobenzene and Aptamer-Modified Substrate

2016 ◽  
Vol 8 (40) ◽  
pp. 27360-27367 ◽  
Author(s):  
Qing Bian ◽  
Wenshuo Wang ◽  
Shutao Wang ◽  
Guojie Wang
Keyword(s):  
Cancer Cell ◽  
Specific Cancer ◽  
Cell Release

Highly efficient near-infrared organic dots based on novel AEE fluorogen for specific cancer cell imaging

RSC Advances ◽  
2015 ◽  
Vol 5 (46) ◽  
pp. 36837-36844 ◽  
Author(s):  
Yan Zhang ◽  
Kaiwen Chang ◽  
Bin Xu ◽  
Jinlong Chen ◽  
Lulin Yan ◽  
...  
Keyword(s):  
Quantum Efficiency ◽  
Cancer Cell ◽  
Small Molecule ◽  
Near Infrared ◽  
Cell Imaging ◽  
Amphiphilic Polymer ◽  
Cancer Cell Imaging ◽  
Highly Efficient ◽  
Specific Cancer ◽  
High Fluorescence

Near-infrared emissive organic dots with a high fluorescence quantum efficiency (AEE dots) are prepared by using an amphiphilic polymer PSMA and a novel small molecule fluorogen (DPPBPA).

scholarly journals Synthesis and Cytotoxic Evaluation of Artemisinin–triazole Hybrids

2016 ◽  
Vol 11 (12) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Doan Duy Tien ◽  
Le Nhat Thuy Giang ◽  
Dang Thi Tuyet Anh ◽  
Nguyen Tien Dung ◽  
Thanh Nguyen Ha ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Click Chemistry ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Cytotoxic Agents ◽  
Artemisinin Derivative ◽  
Hybrid Compounds

Dihydroartemisinin was converted to its corresponding alkyne-functionalized esters, which were subsequently deployed as substrates for a ‘click’ chemistry-mediated coupling with 3′-azido-3′-deoxythydimine (AZT) to furnish novel triazole–artesunate–AZT hybrid compounds. Moreover, various substituted triazole–artemisinin hybrids were synthesized based on ‘click’ chemistry between propargyl-substituted derivatives and artemisinin containing a 2-hydroxypropane unit. Fourteen new hybrids were thus successfully prepared and evaluated as cytotoxic agents, revealing an interesting anticancer activity of four triazole–artemisinin derivative hybrids in KB and HepG2 cancer cell lines.

Design, Synthesis and Antiproliferative Activity of Novel Phenothiazine-1,2,3-Triazole Analogues

2017 ◽  
Vol 41 (12) ◽  
pp. 696-698 ◽  
Author(s):  
Xiao-Hua Ma ◽  
Nan Liu ◽  
Jing-Li Lu ◽  
Jie Zhao ◽  
Xiao-Jian Zhang
Keyword(s):  
Liver Cancer ◽  
Click Chemistry ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Cancer Cell Lines ◽  
Liver Cancer Cell ◽  
Design Synthesis ◽  
Triazole Derivatives

A series of seven novel 1-aryl-1,2,3-triazole derivatives bearing a 4-(phenothiazin-10-ylmethyl) moiety were designed using a molecular hybridisation approach and synthesised by alkyne/azide click chemistry. Most of the synthesised compounds exhibited moderate to good antiproliferative activity (IC50 values: 0.5 to 6.7 μM) against stomach, oesophagus, prostate, breast and liver cancer cell lines, but a compound containing a 4-chlorophenyl moiety showed better activity against all cell lines than 5-fluorouracil.

scholarly journals CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

2011 ◽  
Vol 226 (3) ◽  
pp. 482-494 ◽  
Author(s):  
Alvin J. X. Lee ◽  
Rebecca Roylance ◽  
Jil Sander ◽  
Patricia Gorman ◽  
David Endesfelder ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cell ◽  
Cancer Cell Death ◽  
Autophagy Induction ◽  
Specific Cancer

Hydrogel with supramolecular surface functionalization for cancer cell capture and multicellular spheroid growth and release

2021 ◽  
Author(s):  
Yuting Wen ◽  
Nana Nyarko Mensah ◽  
Xia Song ◽  
Jingling Zhu ◽  
Wui Siew Tan ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Surface Functionalization ◽  
Multicellular Spheroid ◽  
Cell Capture ◽  
Hydrogel Scaffold ◽  
Adhesive Surface ◽  
Spheroid Growth ◽  
Cell Adhesive ◽  
Specific Cancer ◽  
Hydrogel Surface

A hydrogel scaffold with non-fouling but specific cancer cell adhesive surface was fabricated through surface modification using β-cyclodextrin-based host-guest chemistry. Interestingly, the hydrogel surface not only selectively captured specific cancer...

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