Hydrogel with supramolecular surface functionalization for cancer cell capture and multicellular spheroid growth and release

2021 ◽  
Author(s):  
Yuting Wen ◽  
Nana Nyarko Mensah ◽  
Xia Song ◽  
Jingling Zhu ◽  
Wui Siew Tan ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Surface Functionalization ◽  
Multicellular Spheroid ◽  
Cell Capture ◽  
Hydrogel Scaffold ◽  
Adhesive Surface ◽  
Spheroid Growth ◽  
Cell Adhesive ◽  
Specific Cancer ◽  
Hydrogel Surface

A hydrogel scaffold with non-fouling but specific cancer cell adhesive surface was fabricated through surface modification using β-cyclodextrin-based host-guest chemistry. Interestingly, the hydrogel surface not only selectively captured specific cancer...

scholarly journals Folic acid modified electrospun poly(vinyl alcohol)/polyethyleneimine nanofibers for cancer cell capture applications

2016 ◽  
Vol 34 (6) ◽  
pp. 755-765 ◽  
Author(s):  
Zhang-yu Fan ◽  
Yi-li Zhao ◽  
Xiao-yue Zhu ◽  
Yu Luo ◽  
Ming-wu Shen ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cancer Cell ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Cell Capture

PDMS micropillar-based microchip for efficient cancer cell capture

RSC Advances ◽  
2015 ◽  
Vol 5 (64) ◽  
pp. 52161-52166 ◽  
Author(s):  
Jingrong Xiao ◽  
Weiqi He ◽  
Zhengtao Zhang ◽  
Weiying Zhang ◽  
Yiping Cao ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Microfluidic Device ◽  
Cell Capture

We introduce a micropillar-based microfluidic device for efficient and rapid cancer cell capture.

scholarly journals Monocyte Infiltration and Differentiation in 3D Multicellular Spheroid Cancer Models

Pathogens ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 969
Author(s):  
Natasha Helleberg Madsen ◽  
Boye Schnack Nielsen ◽  
Son Ly Nhat ◽  
Søren Skov ◽  
Monika Gad ◽  
...  
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Dependent Manner ◽  
Multicellular Spheroid ◽  
Tumor Associated Macrophages ◽  
Cancer Models ◽  
Ht 29 ◽  
Mcf 7

Tumor-associated macrophages often correlate with tumor progression, and therapies targeting immune cells in tumors have emerged as promising treatments. To select effective therapies, we established an in vitro 3D multicellular spheroid model including cancer cells, fibroblasts, and monocytes. We analyzed monocyte infiltration and differentiation in spheroids generated from fibroblasts and either of the cancer cell lines MCF-7, HT-29, PANC-1, or MIA PaCa-2. Monocytes rapidly infiltrated spheroids and differentiated into mature macrophages with diverse phenotypes in a cancer cell line-dependent manner. MIA PaCa-2 spheroids polarized infiltrating monocytes to M2-like macrophages with high CD206 and CD14 expression, whereas monocytes polarized by MCF-7 spheroids displayed an M1-like phenotype. Monocytes in HT-29 and PANC-1 primarily obtained an M2-like phenotype but also showed upregulation of M1 markers. Analysis of the secretion of 43 soluble factors demonstrated that the cytokine profile between spheroid cultures differed considerably depending on the cancer cell line. Secretion of most of the cytokines increased upon the addition of monocytes resulting in a more inflammatory and pro-tumorigenic environment. These multicellular spheroids can be used to recapitulate the tumor microenvironment and the phenotype of tumor-associated macrophages in vitro and provide more realistic 3D cancer models allowing the in vitro screening of immunotherapeutic compounds.

scholarly journals Transparent, biocompatible nanostructured surfaces for cancer cell capture and culture

2014 ◽  
pp. 2569 ◽  
Author(s):  
Bin Xiong ◽  
Boran Cheng ◽  
Zhaobo He ◽  
Libo Zhao ◽  
Yuanyuan Chen ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Capture ◽  
Nanostructured Surfaces

Light-Triggered Specific Cancer Cell Release from Cyclodextrin/Azobenzene and Aptamer-Modified Substrate

2016 ◽  
Vol 8 (40) ◽  
pp. 27360-27367 ◽  
Author(s):  
Qing Bian ◽  
Wenshuo Wang ◽  
Shutao Wang ◽  
Guojie Wang
Keyword(s):  
Cancer Cell ◽  
Specific Cancer ◽  
Cell Release

A Magnetic Dynamic Microbiointerface with Biofeedback Mechanism for Cancer Cell Capture and Release

2019 ◽  
Vol 11 (44) ◽  
pp. 41019-41029 ◽  
Author(s):  
Xiaohua Tian ◽  
Xiangyu Sha ◽  
Yonghai Feng ◽  
Yuqing Duan ◽  
Mingdong Dong ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Capture ◽  
Magnetic Dynamic ◽  
Capture And Release

Highly efficient near-infrared organic dots based on novel AEE fluorogen for specific cancer cell imaging

RSC Advances ◽  
2015 ◽  
Vol 5 (46) ◽  
pp. 36837-36844 ◽  
Author(s):  
Yan Zhang ◽  
Kaiwen Chang ◽  
Bin Xu ◽  
Jinlong Chen ◽  
Lulin Yan ◽  
...  
Keyword(s):  
Quantum Efficiency ◽  
Cancer Cell ◽  
Small Molecule ◽  
Near Infrared ◽  
Cell Imaging ◽  
Amphiphilic Polymer ◽  
Cancer Cell Imaging ◽  
Highly Efficient ◽  
Specific Cancer ◽  
High Fluorescence

Near-infrared emissive organic dots with a high fluorescence quantum efficiency (AEE dots) are prepared by using an amphiphilic polymer PSMA and a novel small molecule fluorogen (DPPBPA).

Sign in / Sign up

Export Citation Format

Share Document