Double pH-responsive supramolecular copolymer micelles based on the complementary multiple hydrogen bonds of nucleobases and acetalated dextran for drug delivery

2015 ◽  
Vol 6 (19) ◽  
pp. 3625-3633 ◽  
Author(s):  
Huihui Kuang ◽  
Yanjuan Wu ◽  
Zhiyun Zhang ◽  
Jizhen Li ◽  
Xuesi Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hydrogen Bonding ◽  
Hydrogen Bonds ◽  
Ph Responsive ◽  
Copolymer Micelles ◽  
Multiple Hydrogen Bonds

The formation and destabilization of supramolecular micelles based on hydrogen bonding between nucleobases and acetalated dextran.

Supramolecular Copolymer Micelles Based on the Complementary Multiple Hydrogen Bonds of Nucleobases for Drug Delivery

2011 ◽  
Vol 12 (4) ◽  
pp. 1370-1379 ◽  
Author(s):  
Dali Wang ◽  
Yue Su ◽  
Chengyu Jin ◽  
Bangshang Zhu ◽  
Yan Pang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hydrogen Bonds ◽  
Copolymer Micelles ◽  
Multiple Hydrogen Bonds

Selective encapsulation and extraction of hydrogenphosphate by a hydrogen bond donor tripodal receptor

CrystEngComm ◽  
2020 ◽  
Vol 22 (37) ◽  
pp. 6152-6160
Author(s):  
Sandeep Kumar Dey ◽  
Archana ◽  
Sybil Pereira ◽  
Sarvesh S. Harmalkar ◽  
Shashank N. Mhaldar ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Hydrogen Bonding ◽  
Hydrogen Bonds ◽  
Hydrogen Bond Donor ◽  
Tripodal Receptor ◽  
Multiple Hydrogen Bonds

Intramolecular N–H⋯OC hydrogen bonding between the inner amide groups dictates the receptor–anion complementarity in a tripodal receptor towards selective encapsulation of hydrogenphosphate in the outer urea cavity by multiple hydrogen bonds.

Controlling the assembly of hydrogen-bonded supramolecular polymers by the strategy of molecular tectonics

2004 ◽  
Vol 76 (7-8) ◽  
pp. 1345-1351 ◽  
Author(s):  
M.-Č. Perron ◽  
F. Monchamp ◽  
Hugues Duval ◽  
Danielle Boils-Boissier ◽  
J. D. Wuest
Keyword(s):  
Hydrogen Bonding ◽  
Hydrogen Bonds ◽  
Supramolecular Polymers ◽  
Molten State ◽  
Complex Molecules ◽  
Molecular Tectonics ◽  
Bifunctional Molecules ◽  
Multiple Hydrogen Bonding ◽  
Multiple Hydrogen Bonds ◽  
Hydrogen Bonded

Studies of how hydrogen bonding can be used to control molecular association continue to yield exciting discoveries in supramolecular chemistry. A simple way to make molecules that associate predictably is to link carefully selected cores to functional groups that form multiple hydrogen bonds according to reliable patterns. Bifunctional molecules constructed according to this strategy can associate to form linear aggregates robust enough to warrant the name supramolecular polymers, even though the bifunctional monomers are joined only by hydrogen bonds. More complex molecules with multiple hydrogen-bonding sites can be devised so that neighbors are held in predetermined positions, giving crystalline solids with predictable architectures and properties not previously seen in other materials. Initial studies of the ability of such compounds to associate in solution and in the molten state suggest that hydrogen-bonded networks can be purposefully designed to create novel par- tially ordered liquid materials, including liquid crystals, gels, and fluids with unusual rheological properties.

scholarly journals Characterization and optimization of pH-responsive polymer nanoparticles for drug delivery to oral biofilms

2016 ◽  
Vol 4 (18) ◽  
pp. 3075-3085 ◽  
Author(s):  
Jiayi Zhou ◽  
Benjamin Horev ◽  
Geelsu Hwang ◽  
Marlise I. Klein ◽  
Hyun Koo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Polymer Nanoparticles ◽  
Ph Responsive ◽  
Molecular Weights ◽  
Responsive Polymer ◽  
Oral Biofilms ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Corona and core molecular weights of p(DMAEMA)-b-p(DMAEMA-co-BMA-co-PAA) block copolymer micelles can be tuned to enhance drug release in response to acidic milieus consistent with oral biofilms.

Hyperbranched Double Hydrophilic Block Copolymer Micelles of Poly(ethylene oxide) and Polyglycerol for pH-Responsive Drug Delivery

2012 ◽  
Vol 13 (4) ◽  
pp. 1190-1196 ◽  
Author(s):  
Sueun Lee ◽  
Kyohei Saito ◽  
Hye-Ra Lee ◽  
Min Jae Lee ◽  
Yuji Shibasaki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Ethylene Oxide ◽  
Ph Responsive ◽  
Poly Ethylene Oxide ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Poly Ethylene

scholarly journals Photocapture of dynamic hydrogen-bonded assemblies

2004 ◽  
Vol 6 (4) ◽  
pp. 185-192 ◽  
Author(s):  
Nathan D. McClenaghan ◽  
Dario M. Bassani
Keyword(s):  
Hydrogen Bonding ◽  
Hydrogen Bonds ◽  
Supramolecular Assemblies ◽  
Topochemical Reaction ◽  
Hydrogen Bonding Interactions ◽  
Recent Advances ◽  
Weak Hydrogen Bonding ◽  
Supramolecular Template ◽  
Multiple Hydrogen Bonds ◽  
Hydrogen Bonded

Recent advances in the continuing study of [2+2] photodimerization reactions in supramolecular, non-covalent systems are presented. The covalent photocapture of small dynamic assemblies which are formed using weak hydrogen-bonding interactions between two different complementary units, barbiturates and melamines, is discussed. One unit serves as a photo-inert supramolecular template capable of bringing two photoactive units together using multiple hydrogen-bonds. The second type of unit unites the corresponding, complementary hydrogen-bonding motif with a photoactive unit. Irradiation of the supramolecular assemblies leads to photodimerization of adjacent units and generation of an imprinted site for the template. Moieties which are adapted to participate in photodimerization reactions are styrene, cinnamate, stilbene and fullerene units. The results are interpreted on the basis of topochemical reaction control.

Supramolecular prodrug micelles based on the complementary multiple hydrogen bonds as drug delivery platform for thrombosis therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (67) ◽  
pp. 62478-62484 ◽  
Author(s):  
Wen'en Li ◽  
Haibo Wang ◽  
Zeliang Wei ◽  
Juewei Ning ◽  
Limei Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hydrogen Bonds ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Delivery Platform ◽  
Poly Ethylene ◽  
Multiple Hydrogen Bonds

To improve the effect of thrombosis therapy, an amphiphilic supramolecular prodrug consisting of diosgenin derivative (theophylline–diosgenin) and uracil-terminated poly(ethylene glycol) (PEG-U) was designed and synthesized successfully.

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