scholarly journals The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells

2016 ◽  
Vol 14 (3) ◽  
pp. 947-956 ◽  
Author(s):  
Mark C. Bagley ◽  
Jessica E. Dwyer ◽  
Mohammed Baashen ◽  
Matthew C. Dix ◽  
Paola G. S. Murziani ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Werner Syndrome ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
P38α Mapk ◽  
P38 Mapk Inhibitor ◽  
Mapk Inhibitor

Microwave-assisted synthesis of the p38α MAPK inhibitor RO3201195 and its effect on the proliferation of Werner syndrome cells.

scholarly journals Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells

2010 ◽  
Vol 2 (2) ◽  
pp. 203-213 ◽  
Author(s):  
Mark C Bagley ◽  
Terence Davis ◽  
Matthew C Dix ◽  
Paola GS Murziani ◽  
Michal J Rokicki ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Werner Syndrome ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
P38 Mapk Inhibitors ◽  
Mapk Inhibitors

Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome

2010 ◽  
Vol 2 (2) ◽  
pp. 193-201 ◽  
Author(s):  
Mark C Bagley ◽  
Terence Davis ◽  
Michal J Rokicki ◽  
Caroline S Widdowson ◽  
David Kipling
Keyword(s):  
P38 Mapk ◽  
Werner Syndrome ◽  
Therapeutic Use ◽  
P38 Mapk Inhibitor ◽  
Mapk Inhibitor

Additive effects of heat and p38 mapk inhibitor treatment on melanin synthesis

2007 ◽  
Vol 30 (5) ◽  
pp. 581-586 ◽  
Author(s):  
Dong-Seok Kim ◽  
Seo-Hyoung Park ◽  
Sun-Bang Kwon ◽  
Jung-Im Na ◽  
Chang-Hun Huh ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Additive Effects ◽  
Melanin Synthesis ◽  
P38 Mapk Inhibitor ◽  
Inhibitor Treatment ◽  
Mapk Inhibitor

scholarly journals Protective effects of the p38 MAPK inhibitor SB203580 on NMDA-induced injury in primary cerebral cortical neurons

2014 ◽  
Vol 10 (4) ◽  
pp. 1942-1948 ◽  
Author(s):  
XUE-WEN LIU ◽  
EN-FEI JI ◽  
PENG HE ◽  
RUI-XIAN XING ◽  
BU-XIAN TIAN ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Cortical Neurons ◽  
Protective Effects ◽  
Cerebral Cortical Neurons ◽  
P38 Mapk Inhibitor ◽  
Mapk Inhibitor

scholarly journals Metformin combined with p38 MAPK inhibitor improves cisplatin sensitivity in cisplatin-resistant ovarian cancer

2014 ◽  
Vol 10 (5) ◽  
pp. 2346-2350 ◽  
Author(s):  
YA XIE ◽  
ZHENG PENG ◽  
MINGXING SHI ◽  
MEI JI ◽  
HONGJUN GUO ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
P38 Mapk ◽  
Cisplatin Sensitivity ◽  
P38 Mapk Inhibitor ◽  
Mapk Inhibitor

scholarly journals Overexpression of long non coding RNA OR3A4 is associated with altered p38 signalling, morphological and phenotypic changes, and reduced immunogenicity in Barretts Oesophagus

2021 ◽  
Author(s):  
Thomas Nieto ◽  
Yash Sinha ◽  
Qin Qin Zhuang ◽  
Mathew Coleman ◽  
Joanne D Stockton ◽  
...  
Keyword(s):  
T Cells ◽  
P38 Mapk ◽  
Significant Risk ◽  
Oesophageal Adenocarcinoma ◽  
Cellular Phenotype ◽  
Over Expression ◽  
Non Coding Rna ◽  
P38 Mapk Inhibitor ◽  
Long Non Coding Rna ◽  
Mapk Inhibitor

Background: Barretts Oesophagus (BO) presents a particular pathological dilemma, in that patients who have no dysplasia within their BO experience a small but significant risk of malignant progression each year. Screening programmes have attempted to reduce the mortality from BO associated oesophageal adenocarcinoma but cannot predict which BO patients will progress to invasive malignancy. We have previously identified the long non coding RNA, OR3A4, is differentially hypomethylated in progressive BO. We aimed to understand its role in BO pathogenicity Methods: The stable BO cell line CP-A, as well as the oesophageal adenocarcinoma cells line OE-33 was transfected with a lentiviral OR3A4 over-expression vector, and underwent high resolution microscopy, immunofluorescence, RT-qPCR, RNA sequencing, and targeted drug screening with the p38-MAPK inhibitor domipramod to understand the effects of OR3A4 expression on progression. We then compared progressive vs. non-progressive BO samples using quantitative multi-fluorophore (Vectra) immunohistochemistry. Results: Over-expression of OR3A4 in CP-A lines resulted in a hyperproliferative, dysplastic cellular phenotype, with strong over-expression of MAPK and anti-apoptotic pathways at the RNA and protein level, which was sensitive to the p38-MAPK inhibitor domipramod. Vectra immunohistochemistry demonstrated that progressive BO had reduced visibility associated with a reduction in CD8+ T-cells and CD68+ macrophages and reduced CD4+ T-cells in the stomal compartment. Conclusion: The overexpression of OR3A4, which we have previously shown is associated with progressive BO leads to a proliferative dysplastic cellular phenotype associated with increased, reversible MAPK signalling and loss of immune visibility.

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