Molecular binding behaviors and thermodynamics of ferrocenyl dimethylaminium derivatives by anionic pillar[5]arene

2015 ◽  
Vol 13 (44) ◽  
pp. 10808-10812 ◽  
Author(s):  
Cui-Fang Zhang ◽  
Sheng-Hua Li ◽  
Cai-Cai Zhang ◽  
Yu Liu
Keyword(s):  
Water Soluble ◽  
Molecular Binding ◽  
Synthetic Strategy

A novel anionic water-soluble pillar[5]arene (4C-WP5A) was synthesized via a convenient synthetic strategy of the direct cyclization of a functionalized hydroquinone monomer.

Molecular binding behavior of bipyridium derivatives by water-soluble carboxylato-biphen[3]arene

2015 ◽  
Vol 51 (30) ◽  
pp. 6621-6624 ◽  
Author(s):  
Junwei Ma ◽  
Hongmei Deng ◽  
Suxiang Ma ◽  
Jian Li ◽  
Xueshun Jia ◽  
...  
Keyword(s):  
Water Soluble ◽  
Molecular Binding ◽  
Binding Behavior

Complexation of paraquat derivatives and bis(N-mono-substituted bipyridine) cations by a negatively charged carboxylato-biphen[3]arene in water is described.

Interactions between water soluble porphyrin-based star polymer and amino acids: Spectroscopic evidence of molecular binding

2005 ◽  
Vol 71 (2) ◽  
Author(s):  
Nicola Angelini ◽  
Norberto Micali ◽  
Valentina Villari ◽  
Placido Mineo ◽  
Daniele Vitalini ◽  
...  
Keyword(s):  
Amino Acids ◽  
Water Soluble ◽  
Star Polymer ◽  
Spectroscopic Evidence ◽  
Molecular Binding ◽  
Water Soluble Porphyrin

scholarly journals HPMA-Based Polymer Conjugates for Repurposed Drug Mebendazole and Other Imidazole-Based Therapeutics

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2530
Author(s):  
Martin Studenovský ◽  
Anna Rumlerová ◽  
Libor Kostka ◽  
Tomáš Etrych
Keyword(s):  
Chemical Properties ◽  
Drug Repurposing ◽  
Water Soluble ◽  
Biologically Active ◽  
Lysosomal Hydrolases ◽  
Polymer Carrier ◽  
Design Synthesis ◽  
Polymer Conjugates ◽  
Synthetic Strategy ◽  
Physico Chemical

Recently, the antitumor potential of benzimidazole anthelmintics, such as mebendazole and its analogues, have been reported to have minimal side effects, in addition to their well-known anti-parasitic abilities. However, their administration is strongly limited owing to their extremely poor solubility, which highly depletes their overall bioavailability. This study describes the design, synthesis, and physico-chemical properties of polymer-mebendazole nanomedicines for drug repurposing in cancer therapy. The conjugation of mebendazole to water-soluble and biocompatible polymer carrier was carried out via biodegradable bond, relying on the hydrolytic action of lysosomal hydrolases for mebendazole release inside the tumor cells. Five low-molecular-weight mebendazole derivatives, differing in their inner structure, and two polymer conjugates differing in their linker structure, were synthesized. The overall synthetic strategy was designed to enable the modification and polymer conjugation of most benzimidazole-based anthelmintics, such as albendazole, fenbendazole or albendazole, besides the mebendazole. Furthermore, the described methodology may be suitable for conjugation of other biologically active compounds with a heterocyclic N-H group in their molecules.

scholarly journals Tunable benzothiadiazole-based donor–acceptor materials for two-photon excited fluorescence

2020 ◽  
Vol 4 (2) ◽  
pp. 555-566 ◽  
Author(s):  
Nathan R. Paisley ◽  
Christopher M. Tonge ◽  
Don M. Mayder ◽  
Kyle A. Thompson ◽  
Zachary M. Hudson
Keyword(s):  
Water Soluble ◽  
Photon Absorption ◽  
Water Soluble Polymer ◽  
Red Emission ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Synthetic Strategy ◽  
Polymer Dots ◽  
Fluorescent Materials ◽  
Donor Acceptor

Spectrally tunable, two-photon active benzothiadiazole-based fluorescent materials are realized by a simple synthetic strategy. Deep red emission from two-photon absorption, and incorporation into water-soluble polymer dots are achieved.

Molecular binding behavior of water-soluble calix[4]arenes with asymmetric 4,4′-bipyridinium guests in aqueous solution: regioselective recognition or not?

2016 ◽  
Vol 14 (46) ◽  
pp. 10804-10811 ◽  
Author(s):  
Kui Wang ◽  
Jian-Hua Cui ◽  
Si-Yang Xing ◽  
Hong-Xi Dou
Keyword(s):  
Aqueous Solution ◽  
Water Soluble ◽  
Molecular Binding ◽  
Binding Behavior

A unique regioselective recognition of N-methyl-N′-(naphthalen-2-ylmethyl)-4,4′-bipyridinium bromide iodide using a p-sulfonatocalix[4]arene was found.

A two-step synthetic strategy to obtain a water-soluble derivative of curcumin with improved antioxidant capacity and in vitro cytotoxicity in C6 glioma cells

2017 ◽  
Vol 71 ◽  
pp. 351-362 ◽  
Author(s):  
José M. Landeros ◽  
Fernando Belmont-Bernal ◽  
Alma Teresa Pérez-González ◽  
Mario Israel Pérez-Padrón ◽  
Patricia Guevara-Salazar ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Glioma Cells ◽  
C6 Glioma ◽  
In Vitro Cytotoxicity ◽  
Water Soluble ◽  
C6 Glioma Cells ◽  
Synthetic Strategy

scholarly journals Synthesis and Anchoring of Antineoplastic Ferrocene and Phthalocyanine Derivatives on Water-Soluble Polymeric Drug Carriers Derived from Lysine and Aspartic Acid

2008 ◽  
Vol 2008 ◽  
pp. 1-10 ◽  
Author(s):  
M. David Maree ◽  
Eberhard W. Neuse ◽  
Elizabeth Erasmus ◽  
Jannie C. Swarts
Keyword(s):  
Aspartic Acid ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Water Soluble ◽  
Amide Bond ◽  
Drug Conjugates ◽  
Synthetic Strategy ◽  
Coupling Reagent ◽  
Polymeric Drug ◽  
Derivatives Of

The general synthetic strategy towards water-soluble biodegradable drug carriers and the properties that they must have are discussed. The syntheses of water-soluble biodegradable copolymers of lysine and aspartic acid as potential drug-delivering devices, having amine-functionalised side chains are then described. Covalent anchoring of carboxylic acid derivatives of the antineoplastic ferrocene and photodynamically active phthalocyanine moieties to the amine-containing drug carrier copolymers under mild coupling conditions has been achieved utilising the coupling reagent O-benzotriazolyl-N,N,N′,N′-tetramethyluronium hexafluorophosphate to promote formation of the biodegradable amide bond. Even though the parent antineoplastic ferrocene and phthalocyanine derivatives are themselves insoluble in water at pH < 7, the new carrier-drug conjugates that were obtained are well water-soluble.

scholarly journals Solid-phase synthesis and evaluation of tumour-targeting phenylboronate-based MRI contrast agents

2020 ◽  
Vol 18 (39) ◽  
pp. 7899-7906
Author(s):  
Jonathan Martinelli ◽  
Rogelio Jiménez-Juárez ◽  
Diego Alberti ◽  
Simonetta Geninatti Crich ◽  
Kristina Djanashvili
Keyword(s):  
Contrast Agents ◽  
Functional Groups ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Mri Contrast Agents ◽  
Water Soluble ◽  
Tumour Targeting ◽  
Mri Contrast ◽  
Phase Synthesis ◽  
Synthetic Strategy

The advantage of a solid-phase synthetic strategy with DEAM-PS resin is applied for a clean and efficient preparation of water-soluble DOTA derivatives conjugated with phenylboronic functional groups.

A Resorcinol-Formaldehyde Resin as an Embedding Material for Electron Microscopy of Membranes

1969 ◽  
Vol 27 ◽  
pp. 328-329 ◽  
Author(s):  
J. G. Robertson ◽  
D. F. Parsons
Keyword(s):  
Electron Microscopy ◽  
Osmium Tetroxide ◽  
Neutral Lipids ◽  
Lipid Extraction ◽  
Water Soluble ◽  
Formaldehyde Resin ◽  
Electron Microscope Autoradiography ◽  
Resorcinol Formaldehyde ◽  
Major Disadvantage ◽  
Cell Organization

The extraction of lipids from tissues during fixation and embedding for electron microscopy is widely recognized as a source of possible artifact, especially at the membrane level of cell organization. Lipid extraction is also a major disadvantage in electron microscope autoradiography of radioactive lipids, as in studies of the uptake of radioactive fatty acids by intestinal slices. Retention of lipids by fixation with osmium tetroxide is generally limited to glycolipids, phospholipids and highly unsaturated neutral lipids. Saturated neutral lipids and sterols tend to be easily extracted by organic dehydrating reagents prior to embedding. Retention of the more saturated lipids in embedded tissue might be achieved by developing new cross-linking reagents, by the use of highly water soluble embedding materials or by working at very low temperatures.

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