Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells

2015 ◽  
Vol 13 (40) ◽  
pp. 10226-10235 ◽  
Author(s):  
Yi-Min Liu ◽  
Hsueh-Yun Lee ◽  
Mei-Jung Lai ◽  
Shiow-Lin Pan ◽  
Hsiang-Ling Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Histone Deacetylase 6 ◽  
Hct116 Cells

We synthesized a series of pyrimidinedione derivatives and evaluated their activities.

Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models

2019 ◽  
Vol 62 (18) ◽  
pp. 8557-8577 ◽  
Author(s):  
Sida Shen ◽  
Melissa Hadley ◽  
Kseniya Ustinova ◽  
Jiri Pavlicek ◽  
Tessa Knox ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Mouse Models ◽  
Histone Deacetylase 6

Histone deacetylase 6– HDAC6– a new regulator of glucocorticoid receptor-mediated metabolic processes

2010 ◽  
Vol 5 (S 01) ◽  
Author(s):  
R Winkler ◽  
M Clemenz ◽  
M Bloch ◽  
A Foryst-Ludwig ◽  
C Böhm ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Histone Deacetylase ◽  
Histone Deacetylase 6 ◽  
Metabolic Processes
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