scholarly journals Effects of histone deacetylase inhibitors on ATP‑binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells

2019 ◽  
Author(s):  
Hao Wang ◽  
Chun‑Hua Chi ◽  
Ying Zhang ◽  
Bin Shi ◽  
Ru Jia ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lung Cancer ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Atp Binding ◽  
Atp Binding Cassette Transporters ◽  
Hct116 Cells ◽  
Atp Binding Cassette

scholarly journals The Mechanisms of Yu Ping Feng San in Tracking the Cisplatin-Resistance by Regulating ATP-Binding Cassette Transporter and Glutathione S-Transferase in Lung Cancer Cells

2021 ◽  
Vol 12 ◽  
Author(s):  
Yingqing Du ◽  
Yuzhong Zheng ◽  
Ciel Xiaomei Yu ◽  
Lishan Zhong ◽  
Yafang Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Cell Viability ◽  
Cancer Cells ◽  
Cisplatin Resistance ◽  
Atp Binding ◽  
Anti Cancer ◽  
Atp Binding Cassette Transporters ◽  
Cisplatin Accumulation ◽  
Atp Binding Cassette

Cisplatin is one of the first line anti-cancer drugs prescribed for treatment of solid tumors; however, the chemotherapeutic drug resistance is still a major obstacle of cisplatin in treating cancers. Yu Ping Feng San (YPFS), a well-known ancient Chinese herbal combination formula consisting of Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, is prescribed as a herbal decoction to treat immune disorders in clinic. To understand the fast-onset action of YPFS as an anti-cancer drug to fight against the drug resistance of cisplatin, we provided detailed analyses of intracellular cisplatin accumulation, cell viability, and expressions and activities of ATP-binding cassette transporters and glutathione S-transferases (GSTs) in YPFS-treated lung cancer cell lines. In cultured A549 or its cisplatin-resistance A549/DDP cells, application of YPFS increased accumulation of intracellular cisplatin, resulting in lower cell viability. In parallel, the activities and expressions of ATP-binding cassette transporters and GSTs were down-regulated in the presence of YPFS. The expression of p65 subunit of NF-κB complex was reduced by treating the cultures with YPFS, leading to a high ratio of Bax/Bcl-2, i.e. increasing the rate of cell death. Prim-O-glucosylcimifugin, one of the abundant ingredients in YPFS, modulated the activity of GSTs, and then elevated cisplatin accumulation, resulting in increased cell apoptosis. The present result supports the notion of YPFS in reversing drug resistance of cisplatin in lung cancer cells by elevating of intracellular cisplatin, and the underlying mechanism may be down regulating the activities and expressions of ATP-binding cassette transporters and GSTs.

scholarly journals Increased expressions of cellular ATP-binding cassette transporters may be a promising diagnostic marker for colorectal cancer

2020 ◽  
Vol 41 (8) ◽  
pp. 834-840
Author(s):  
Renad Qutub ◽  
Ayat Al-Ghafari ◽  
Huda Al Doghaither ◽  
Ulfat Omar ◽  
Jihan Ghulam
Keyword(s):  
Colorectal Cancer ◽  
Diagnostic Marker ◽  
Atp Binding ◽  
Atp Binding Cassette Transporters ◽  
Atp Binding Cassette

scholarly journals Stimulation of Cholesterol Excretion by the Liver X Receptor Agonist Requires ATP-binding Cassette Transporters G5 and G8

2003 ◽  
Vol 278 (18) ◽  
pp. 15565-15570 ◽  
Author(s):  
Liqing Yu ◽  
Jennifer York ◽  
Klaus von Bergmann ◽  
Dieter Lutjohann ◽  
Jonathan C. Cohen ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Liver X Receptor ◽  
Atp Binding ◽  
Atp Binding Cassette Transporters ◽  
Cholesterol Excretion ◽  
Liver X Receptor Agonist ◽  
Stimulation Of ◽  
Atp Binding Cassette
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