Scalable synthesis of the unusual amino acid segment (ADMOA unit) of marine anti-inflammatory peptide: solomonamide A

2015 ◽  
Vol 13 (22) ◽  
pp. 6242-6248 ◽  
Author(s):  
Nerella Kavitha ◽  
Srivari Chandrasekhar
Keyword(s):  
Amino Acid ◽  
New Approach ◽  
Anti Inflammatory ◽  
Scalable Synthesis ◽  
Amino Acid Segment ◽  
Unusual Amino Acid

A new approach has been developed for the synthesis of the unusual amino acid segment (ADMOA unit) of solomonamide A starting from d-glucose.

Scalable Synthesis of L-allo-Enduracididine: The Unusual Amino Acid Present in Teixobactin

Synlett ◽  
2021 ◽  
Author(s):  
Srivari Chandrashekar ◽  
Namdeo Gangathade ◽  
Kiranmai Nayani ◽  
Hemalatha Bukya ◽  
Prathama S Mainkar
Keyword(s):  
Amino Acid ◽  
Synthetic Route ◽  
Asymmetric Dihydroxylation ◽  
Scalable Synthesis ◽  
Unusual Amino Acid ◽  
Synthetic Transformations

A scalable synthesis of L-allo-enduracididine is achieved from commercially available (S)-glycidol in ten linear steps involving well established synthetic transformations. The synthetic route is flexible and can be used to synthesize all four diastereomers, by changing the stereochemistry of glycidol and Sharpless asymmetric dihydroxylation reagent.

scholarly journals Synthetic study on dolastatin 16: concise and scalable synthesis of two unusual amino acid units

2015 ◽  
Vol 56 (1) ◽  
pp. 168-171 ◽  
Author(s):  
Taiki Umezawa ◽  
Akinori Sato ◽  
Yasuto Ameda ◽  
Loida O. Casalme ◽  
Fuyuhiko Matsuda
Keyword(s):  
Amino Acid ◽  
Scalable Synthesis ◽  
Unusual Amino Acid

scholarly journals Neuroimmune Response Mediated by Cytokines in Natural Scrapie after Chronic Dexamethasone Treatment

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 204
Author(s):  
Isabel M. Guijarro ◽  
Moisés Garcés ◽  
Pol Andrés-Benito ◽  
Belén Marín ◽  
Alicia Otero ◽  
...  
Keyword(s):  
Prion Diseases ◽  
Global Approach ◽  
Profile Data ◽  
Dexamethasone Treatment ◽  
New Approach ◽  
Complex Interactions ◽  
Natural Scrapie ◽  
Anti Inflammatory

The actual role of prion protein-induced glial activation and subsequent cytokine secretion during prion diseases is still incompletely understood. The overall aim of this study is to assess the effect of an anti-inflammatory treatment with dexamethasone on different cytokines released by neuroglial cells that are potentially related to neuroinflammation in natural scrapie. This study emphasizes the complex interactions existent among several pleiotropic neuromodulator peptides and provides a global approach to clarify neuroinflammatory processes in prion diseases. Additionally, an impairment of communication between microglial and astroglial populations mediated by cytokines, mainly IL-1, is suggested. The main novelty of this study is that it is the first one assessing in situ neuroinflammatory activity in relation to chronic anti-inflammatory therapy, gaining relevance because it is based on a natural model. The cytokine profile data would suggest the activation of some neurotoxicity-associated route. Consequently, targeting such a pathway might be a new approach to modify the damaging effects of neuroinflammation.

scholarly journals Avoided motifs: short amino acid strings missing from protein datasets

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Pablo Mier ◽  
Miguel A. Andrade-Navarro
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Protein Function ◽  
Large Protein ◽  
New Approach ◽  
Cellular Context ◽  
Human Proteins ◽  
Context Specific ◽  
Protein Datasets

Abstract According to the amino acid composition of natural proteins, it could be expected that all possible sequences of three or four amino acids will occur at least once in large protein datasets purely by chance. However, in some species or cellular context, specific short amino acid motifs are missing due to unknown reasons. We describe these as Avoided Motifs, short amino acid combinations missing from biological sequences. Here we identify 209 human and 154 bacterial Avoided Motifs of length four amino acids, and discuss their possible functionality according to their presence in other species. Furthermore, we determine two Avoided Motifs of length three amino acids in human proteins specifically located in the cytoplasm, and two more in secreted proteins. Our results support the hypothesis that the characterization of Avoided Motifs in particular contexts can provide us with information about functional motifs, pointing to a new approach in the use of molecular sequences for the discovery of protein function.

scholarly journals Identification of the Active Principle Conferring Anti-Inflammatory and Antinociceptive Properties in Bamboo Plant

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 3054
Author(s):  
Bruna Araujo Sousa ◽  
Osmar Nascimento Silva ◽  
William Farias Porto ◽  
Thales Lima Rocha ◽  
Luciano Paulino Silva ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Folk Medicine ◽  
Active Principle ◽  
Therapeutic Effects ◽  
Protein Biochemistry ◽  
Antinociceptive Effects ◽  
Cellular Pathways ◽  
Anti Inflammatory ◽  
Bamboo Plant

Early plants began colonizing earth about 450 million years ago. During the process of coevolution, their metabolic cellular pathways produced a myriad of natural chemicals, many of which remain uncharacterized biologically. Popular preparations containing some of these molecules have been used medicinally for thousands of years. In Brazilian folk medicine, plant extracts from the bamboo plant Guadua paniculata Munro have been used for the treatment of infections and pain. However, the chemical basis of these therapeutic effects has not yet been identified. Here, we performed protein biochemistry and downstream pharmacological assays to determine the mechanisms underlying the anti-inflammatory and antinociceptive effects of an aqueous extract of the G. paniculata rhizome, which we termed AqGP. The anti-inflammatory and antinociceptive effects of AqGP were assessed in mice. We identified and purified a protein (AgGP), with an amino acid sequence similar to that of thaumatins (~20 kDa), capable of repressing inflammation through downregulation of neutrophil recruitment and of decreasing hyperalgesia in mice. In conclusion, we have identified the molecule and the molecular mechanism responsible for the anti-inflammatory and antinociceptive properties of a plant commonly used in Brazilian folk medicine.

Streptokinase secretion by Serratia marcescens signaled by the C-terminal 41 amino acid segment of metalloprotease

IUBMB Life ◽  
1998 ◽  
Vol 45 (4) ◽  
pp. 725-733
Author(s):  
Ki Seok Kim ◽  
Kwang Hee Bae ◽  
Il Chul Kim ◽  
Si Myung Byun ◽  
Yong Chul Shin
Keyword(s):  
Amino Acid ◽  
Serratia Marcescens ◽  
Amino Acid Segment
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