ChemInform Abstract: A NEW APPROACH TO THE PREPARATION OF N-CARBOXY α-AMINO ACID ANHYDRIDES

1985 ◽  
Vol 16 (47) ◽  
Author(s):  
S. MOBASHERY ◽  
M. JOHNSTON
Keyword(s):  
Amino Acid ◽  
New Approach ◽  
Acid Anhydrides

A new approach to the preparation of N-carboxy .alpha.-amino acid anhydrides

1985 ◽  
Vol 50 (12) ◽  
pp. 2200-2202 ◽  
Author(s):  
Shahriar Mobashery ◽  
Michael Johnston
Keyword(s):  
Amino Acid ◽  
New Approach ◽  
Acid Anhydrides ◽  
Alpha Amino Acid

scholarly journals Avoided motifs: short amino acid strings missing from protein datasets

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Pablo Mier ◽  
Miguel A. Andrade-Navarro
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Protein Function ◽  
Large Protein ◽  
New Approach ◽  
Cellular Context ◽  
Human Proteins ◽  
Context Specific ◽  
Protein Datasets

Abstract According to the amino acid composition of natural proteins, it could be expected that all possible sequences of three or four amino acids will occur at least once in large protein datasets purely by chance. However, in some species or cellular context, specific short amino acid motifs are missing due to unknown reasons. We describe these as Avoided Motifs, short amino acid combinations missing from biological sequences. Here we identify 209 human and 154 bacterial Avoided Motifs of length four amino acids, and discuss their possible functionality according to their presence in other species. Furthermore, we determine two Avoided Motifs of length three amino acids in human proteins specifically located in the cytoplasm, and two more in secreted proteins. Our results support the hypothesis that the characterization of Avoided Motifs in particular contexts can provide us with information about functional motifs, pointing to a new approach in the use of molecular sequences for the discovery of protein function.

New Approach to the Coupling of γ-Amino β-Hydroxy Acids and β,γ-Dihydroxy Acids with α-Amino Acid Esters

1996 ◽  
Vol 61 (26) ◽  
pp. 9196-9201 ◽  
Author(s):  
Claudio Palomo ◽  
José I. Miranda ◽  
Anthony Linden
Keyword(s):  
Amino Acid ◽  
Amino Acid Esters ◽  
Hydroxy Acids ◽  
New Approach ◽  
Acid Esters

scholarly journals Electrospinning and Post-Spun Chain Conformations of Synthetic, Hydrophobic Poly(α-amino acid)s

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 327 ◽  
Author(s):  
Kesavan Devarayan ◽  
Souta Nakagami ◽  
Shuichi Suzuki ◽  
Ichiro Yuki ◽  
Kousaku Ohkawa
Keyword(s):  
Amino Acid ◽  
Trifluoroacetic Acid ◽  
Average Molecular Weight ◽  
Helical Structure ◽  
Degree Of Polymerization ◽  
Random Coil ◽  
X Ray Diffraction ◽  
Ft Ir ◽  
Acid Anhydrides ◽  
Chain Conformations

Electrospinning and post-spun conformations of hydrophobic poly(α-amino acid)s are described in this study. The poly(α-amino acid)s, poly(Gly), poly(l-Ala), poly(l-Val), and poly(l-Leu) were synthesized via corresponding N-carboxy-α-amino acid anhydrides. The average molecular weight and degree of polymerization of these polymers were determined by N-terminus labeling using 2,4-dinitrofluorobenzene and by viscometry in the case of poly(Gly). These poly(α-amino acid)s were electrospun from trifluoroacetic acid or trifluoroacetic acid/dichloromethane solutions. The FT-IR spectroscopy and wide-angle X-ray diffraction indicated that the electrospun poly(l-Ala) and poly(l-Leu) fibers predominantly adopts α-helical structure, whereas poly(l-Val) and poly(Gly) fibers exhibited mainly β-strand and random coil structures, respectively.

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