scholarly journals Towards 4th generation biomaterials: a covalent hybrid polymer–ormoglass architecture

Nanoscale ◽  
2015 ◽  
Vol 7 (37) ◽  
pp. 15349-15361 ◽  
Author(s):  
N. Sachot ◽  
M. A. Mateos-Timoneda ◽  
J. A. Planell ◽  
A. H. Velders ◽  
M. Lewandowska ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Cell Fate ◽  
Hybrid Materials ◽  
Hybrid Polymer ◽  
Fate Control ◽  
Cell Fate Control

Nanostructured hybrid materials are an excellent option to create extracellular matrix-like environments for cell fate control in bone tissue engineering.

scholarly journals A New Approach for Glyco-Functionalization of Collagen-Based Biomaterials

2019 ◽  
Vol 20 (7) ◽  
pp. 1747 ◽  
Author(s):  
Ines Figuereido ◽  
Alice Paiotta ◽  
Roberta Dal Magro ◽  
Francesca Tinelli ◽  
Roberta Corti ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Cell Fate ◽  
Cell Biology ◽  
Aqueous Media ◽  
New Approach ◽  
Cell Microenvironment ◽  
Fate Control ◽  
Ecm Proteins ◽  
Cell Fate Control

The cell microenvironment plays a pivotal role in mediating cell adhesion, survival, and proliferation in physiological and pathological states. The relevance of extracellular matrix (ECM) proteins in cell fate control is an important issue to take into consideration for both tissue engineering and cell biology studies. The glycosylation of ECM proteins remains, however, largely unexplored. In order to investigate the physio-pathological effects of differential ECM glycosylation, the design of affordable chemoselective methods for ECM components glycosylation is desirable. We will describe a new chemoselective glycosylation approach exploitable in aqueous media and on non-protected substrates, allowing rapid access to glyco-functionalized biomaterials.

scholarly journals Cell-secreted extracellular matrix, independent of cell source, promotes the osteogenic differentiation of human stromal vascular fraction

2018 ◽  
Vol 6 (24) ◽  
pp. 4104-4115 ◽  
Author(s):  
Jenna N. Harvestine ◽  
Hakan Orbay ◽  
Jonathan Y. Chen ◽  
David E. Sahar ◽  
J. Kent Leach
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Osteogenic Differentiation ◽  
Bone Tissue ◽  
Stromal Vascular Fraction ◽  
Cell Source

Cell-secreted extracellular matrix potentiates osteogenic differentiation by stromal vascular fraction for bone tissue engineering.

scholarly journals Fabrication of Decellularized Engineered Extracellular Matrix through Bioreactor-Based Environment for Bone Tissue Engineering

ACS Omega ◽  
2020 ◽  
Vol 5 (49) ◽  
pp. 31943-31956
Author(s):  
Hanieh Nokhbatolfoghahaei ◽  
Zahrasadat Paknejad ◽  
Mahboubeh Bohlouli ◽  
Maryam Rezai Rad ◽  
Pouyan Aminishakib ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Tissue

scholarly journals Alginate- and gelatin-based bioactive photocross-linkable hybrid materials for bone tissue engineering

2017 ◽  
Vol 157 ◽  
pp. 1714-1722 ◽  
Author(s):  
Joanna Lewandowska-Łańcucka ◽  
Katarzyna Mystek ◽  
Arn Mignon ◽  
Sandra Van Vlierberghe ◽  
Anna Łatkiewicz ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Hybrid Materials

Via precise interface engineering towards bioinspired composites with improved 3D printing processability and mechanical properties

2017 ◽  
Vol 5 (25) ◽  
pp. 5037-5047 ◽  
Author(s):  
Felix Hanßke ◽  
Onur Bas ◽  
Cédryck Vaquette ◽  
Gernot Hochleitner ◽  
Jürgen Groll ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Hybrid Materials ◽  
Elastic Moduli ◽  
Interface Engineering ◽  
Organic Hybrid ◽  
Biodegradable Composite

Precise interface engineering in inorganic–organic hybrid materials enhances both the elastic moduli and toughness of a biodegradable composite, which is of relevance for load-bearing applications in bone tissue engineering.

scholarly journals An ECM-Mimicking, Mesenchymal Stem Cell-Embedded Hybrid Scaffold for Bone Regeneration

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Jozafina Haj ◽  
Tharwat Haj Khalil ◽  
Mizied Falah ◽  
Eyal Zussman ◽  
Samer Srouji
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Bone Repair ◽  
Dorsal Side ◽  
Human Mscs ◽  
Hybrid Scaffold

While biologically feasible, bone repair is often inadequate, particularly in cases of large defects. The search for effective bone regeneration strategies has led to the emergence of bone tissue engineering (TE) techniques. When integrating electrospinning techniques, scaffolds featuring randomly oriented or aligned fibers, characteristic of the extracellular matrix (ECM), can be fabricated. In parallel, mesenchymal stem cells (MSCs), which are capable of both self-renewing and differentiating into numerous tissue types, have been suggested to be a suitable option for cell-based tissue engineering therapies. This work aimed to create a novel biocompatible hybrid scaffold composed of electrospun polymeric nanofibers combined with osteoconductive ceramics, loaded with human MSCs, to yield a tissue-like construct to promote in vivo bone formation. Characterization of the cell-embedded scaffolds demonstrated their resemblance to bone tissue extracellular matrix, on both micro- and nanoscales and MSC viability and integration within the electrospun nanofibers. Subcutaneous implantation of the cell-embedded scaffolds in the dorsal side of mice led to new bone, muscle, adipose, and connective tissue formation within 8 weeks. This hybrid scaffold may represent a step forward in the pursuit of advanced bone tissue engineering scaffolds.

Hybrid materials for bone tissue engineering from biomimetic growth of hydroxiapatite on cellulose nanowhiskers

2016 ◽  
Vol 152 ◽  
pp. 734-746 ◽  
Author(s):  
Elizângela H. Fragal ◽  
Thelma S.P. Cellet ◽  
Vanessa H. Fragal ◽  
Mychelle V.P. Companhoni ◽  
Tânia Ueda-Nakamura ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Hybrid Materials ◽  
Cellulose Nanowhiskers
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