scholarly journals Fabrication of Decellularized Engineered Extracellular Matrix through Bioreactor-Based Environment for Bone Tissue Engineering

ACS Omega ◽  
2020 ◽  
Vol 5 (49) ◽  
pp. 31943-31956
Author(s):  
Hanieh Nokhbatolfoghahaei ◽  
Zahrasadat Paknejad ◽  
Mahboubeh Bohlouli ◽  
Maryam Rezai Rad ◽  
Pouyan Aminishakib ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Tissue

scholarly journals Cell-secreted extracellular matrix, independent of cell source, promotes the osteogenic differentiation of human stromal vascular fraction

2018 ◽  
Vol 6 (24) ◽  
pp. 4104-4115 ◽  
Author(s):  
Jenna N. Harvestine ◽  
Hakan Orbay ◽  
Jonathan Y. Chen ◽  
David E. Sahar ◽  
J. Kent Leach
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Osteogenic Differentiation ◽  
Bone Tissue ◽  
Stromal Vascular Fraction ◽  
Cell Source

Cell-secreted extracellular matrix potentiates osteogenic differentiation by stromal vascular fraction for bone tissue engineering.

scholarly journals An ECM-Mimicking, Mesenchymal Stem Cell-Embedded Hybrid Scaffold for Bone Regeneration

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Jozafina Haj ◽  
Tharwat Haj Khalil ◽  
Mizied Falah ◽  
Eyal Zussman ◽  
Samer Srouji
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Bone Repair ◽  
Dorsal Side ◽  
Human Mscs ◽  
Hybrid Scaffold

While biologically feasible, bone repair is often inadequate, particularly in cases of large defects. The search for effective bone regeneration strategies has led to the emergence of bone tissue engineering (TE) techniques. When integrating electrospinning techniques, scaffolds featuring randomly oriented or aligned fibers, characteristic of the extracellular matrix (ECM), can be fabricated. In parallel, mesenchymal stem cells (MSCs), which are capable of both self-renewing and differentiating into numerous tissue types, have been suggested to be a suitable option for cell-based tissue engineering therapies. This work aimed to create a novel biocompatible hybrid scaffold composed of electrospun polymeric nanofibers combined with osteoconductive ceramics, loaded with human MSCs, to yield a tissue-like construct to promote in vivo bone formation. Characterization of the cell-embedded scaffolds demonstrated their resemblance to bone tissue extracellular matrix, on both micro- and nanoscales and MSC viability and integration within the electrospun nanofibers. Subcutaneous implantation of the cell-embedded scaffolds in the dorsal side of mice led to new bone, muscle, adipose, and connective tissue formation within 8 weeks. This hybrid scaffold may represent a step forward in the pursuit of advanced bone tissue engineering scaffolds.

scholarly journals Towards 4th generation biomaterials: a covalent hybrid polymer–ormoglass architecture

Nanoscale ◽  
2015 ◽  
Vol 7 (37) ◽  
pp. 15349-15361 ◽  
Author(s):  
N. Sachot ◽  
M. A. Mateos-Timoneda ◽  
J. A. Planell ◽  
A. H. Velders ◽  
M. Lewandowska ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Cell Fate ◽  
Hybrid Materials ◽  
Hybrid Polymer ◽  
Fate Control ◽  
Cell Fate Control

Nanostructured hybrid materials are an excellent option to create extracellular matrix-like environments for cell fate control in bone tissue engineering.

An In Vitro Assessment of a Cell-Containing Collagenous Extracellular Matrix–like Scaffold for Bone Tissue Engineering

2010 ◽  
Vol 16 (3) ◽  
pp. 781-793 ◽  
Author(s):  
Claudio E. Pedraza ◽  
Benedetto Marelli ◽  
Florencia Chicatun ◽  
Marc D. McKee ◽  
Showan N. Nazhat
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
A Cell ◽  
In Vitro Assessment

scholarly journals Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 599
Author(s):  
Gustavo A. Rico-Llanos ◽  
Sara Borrego-González ◽  
Miguelangel Moncayo-Donoso ◽  
José Becerra ◽  
Rick Visser
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Mechanical Strength ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Collagen Type ◽  
Collagen Type I ◽  
Current Status ◽  
Type I ◽  
Organic Constituent

Collagen type I is the main organic constituent of the bone extracellular matrix and has been used for decades as scaffolding material in bone tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources and can be processed in a great number of ways to manufacture biomaterials in the form of sponges, particles, or hydrogels, among others, for different applications. Despite its great biocompatibility and osteoconductivity, collagen type I also has some drawbacks, such as its high biodegradability, low mechanical strength, and lack of osteoinductive activity. Therefore, many attempts have been made to improve the collagen type I-based implants for bone tissue engineering. This review aims to summarize the current status of collagen type I as a biomaterial for bone tissue engineering, as well as to highlight some of the main efforts that have been made recently towards designing and producing collagen implants to improve bone regeneration.

Demineralized and decellularized bone extracellular matrix incorporated electrospun nanofibrous scaffold for bone regeneration

2021 ◽  
Author(s):  
Chanjuan Dong ◽  
Fangyu Qiao ◽  
Guobao Chen ◽  
Yonggang Lv
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Cell Attachment ◽  
Nanofibrous Scaffold ◽  
Proliferation And Differentiation

The extracellular matrix (ECM)-based materials has been employed as scaffolds for bone tissue engineering, providing a suitable microenvironment that possesses biophysical and biochemical cues for cell attachment, proliferation and differentiation....

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