Can graphene quantum dots cause DNA damage in cells?

Nanoscale ◽  
2015 ◽  
Vol 7 (21) ◽  
pp. 9894-9901 ◽  
Author(s):  
Dan Wang ◽  
Lin Zhu ◽  
Jian-Feng Chen ◽  
Liming Dai
Keyword(s):  
Dna Damage ◽  
Quantum Dots ◽  
Graphene Quantum Dots ◽  
In Cells

scholarly journals Hydroxylated-Graphene Quantum Dots Induce DNA Damage and Disrupt Microtubule Structure in Human Esophageal Epithelial Cells

2018 ◽  
Vol 164 (1) ◽  
pp. 339-352 ◽  
Author(s):  
Ming Li ◽  
Meng-Meng Gu ◽  
Xin Tian ◽  
Bei-Bei Xiao ◽  
Siyuan Lu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Quantum Dots ◽  
Epithelial Cells ◽  
Graphene Quantum Dots ◽  
Esophageal Epithelial Cells ◽  
Microtubule Structure

Electrochemiluminescence resonance energy transfer between graphene quantum dots and gold nanoparticles for DNA damage detection

The Analyst ◽  
2014 ◽  
Vol 139 (10) ◽  
pp. 2404-2410 ◽  
Author(s):  
Qian Lu ◽  
Wei Wei ◽  
Zhenxian Zhou ◽  
Zhixin Zhou ◽  
Yuanjian Zhang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Quantum Dots ◽  
Gold Nanoparticles ◽  
Energy Transfer ◽  
Damage Detection ◽  
Au Nanoparticles ◽  
Graphene Quantum Dots ◽  
Resonance Energy Transfer ◽  
Resonance Energy

Electrochemiluminescence resonance energy transfer between graphene quantum dots (GQDs) and Au nanoparticles results in the electrochemiluminescence signal of the GQDs being quenched or recovering.

scholarly journals Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Lei Qi ◽  
Tonghe Pan ◽  
Liling Ou ◽  
Zhiqiang Ye ◽  
Chunlei Yu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Quantum Dots ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Electrostatic Interactions ◽  
Rational Design ◽  
Graphene Quantum Dots ◽  
Cell Targeting ◽  
Disulfide Linkage ◽  
Cancer Cell Targeting

AbstractGraphene quantum dots (GQDs) are nano-sized graphene slices. With their small size, lamellar and aromatic-ring structure, GQDs tend to enter into the cell nucleus and interfere with DNA activity. Thus, GQD alone is expected to be an anticancer reagent. Herein, we developed GQDs that suppress the growth of tumor by selectively damaging the DNA of cancer cells. The amine-functionalized GQDs were modified with nucleus targeting TAT peptides (TAT-NGs) and further grafted with cancer-cell-targeting folic acid (FA) modified PEG via disulfide linkage (FAPEG-TNGs). The resulting FAPEG-TNGs exhibited good biocompatibility, nucleus uptake, and cancer cell targeting. They adsorb on DNA via the π–π and electrostatic interactions, which induce the DNA damage, the upregulation of the cell apoptosis related proteins, and the suppression of cancer cell growth, ultimately. This work presents a rational design of GQDs that induce the DNA damage to realize high therapeutic performance, leading to a distinct chemotherapy strategy for targeted tumor therapy.

Use of the comet assay to measure DNA damage in cells exposed to photosensitizers and gamma radiation

1999 ◽  
Vol 96 (1) ◽  
pp. 143-146 ◽  
Author(s):  
J.-P. Pouget ◽  
J.-L. Ravanat ◽  
T. Douki ◽  
M.-J. Richard ◽  
J. Cadet
Keyword(s):  
Dna Damage ◽  
Comet Assay ◽  
Gamma Radiation ◽  
In Cells

Preparation of Graphene Quantum Dots and Their Biological Applications

2016 ◽  
Vol 31 (4) ◽  
pp. 337 ◽  
Author(s):  
SUN Xiao-Dan ◽  
LIU Zhong-Qun ◽  
YAN Hao
Keyword(s):  
Quantum Dots ◽  
Graphene Quantum Dots ◽  
Biological Applications

Effect of graphene quantum dots on intestinal imaging and mesenteric microcirculation in mice

2014 ◽  
Vol 35 (4) ◽  
pp. 372
Author(s):  
Yong-qiang MA ◽  
Zhen-guo WANG ◽  
Xue-li GOU ◽  
Na LI ◽  
Ya-qiang FENG ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Graphene Quantum Dots ◽  
Mesenteric Microcirculation
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