Bridge between Temperature and Light: Bottom-Up Synthetic Route to Structure-Defined Graphene Quantum Dots as a Temperature Probe In Vitro and in Cells

2020 ◽  
Vol 12 (19) ◽  
pp. 22002-22011 ◽  
Author(s):  
Tian Gao ◽  
Xi Wang ◽  
Jie Zhao ◽  
Peng Jiang ◽  
Feng-Lei Jiang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Graphene Quantum Dots ◽  
Synthetic Route ◽  
Bottom Up ◽  
Temperature Probe ◽  
In Cells

(Invited) In Vitro and In Vivo Near-Infrared Imaging with Biocompatible Bottom-up and Top-Down-Synthesized Graphene Quantum Dots

2020 ◽  
Vol MA2020-01 (6) ◽  
pp. 648-648
Author(s):  
Anton V Naumov ◽  
Md Tanvir Hasan ◽  
Elizabeth Campbell ◽  
Ching-Wei Lin ◽  
Angela M. Belcher
Keyword(s):  
Quantum Dots ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Graphene Quantum Dots ◽  
Top Down ◽  
Near Infrared Imaging ◽  
Bottom Up

(Invited) In Vitro and In Vivo Near-Infrared Imaging with Biocompatible Bottom-up and Top-Down-Synthesized Graphene Quantum Dots

2021 ◽  
Vol MA2021-01 (10) ◽  
pp. 534-534
Author(s):  
Anton V. Naumov ◽  
Md. Tanvir Hasan ◽  
Ching-Wei Lin ◽  
Angela Belcher ◽  
Jeffery Coffer ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Graphene Quantum Dots ◽  
Top Down ◽  
Near Infrared Imaging ◽  
Bottom Up

scholarly journals Effects of Doxorubicin Delivery by Nitrogen-Doped Graphene Quantum Dots on Cancer Cell Growth: Experimental Study and Mathematical Modeling

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 140
Author(s):  
Madison Frieler ◽  
Christine Pho ◽  
Bong Han Lee ◽  
Hana Dobrovolny ◽  
Giridhar R. Akkaraju ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Cell Growth ◽  
Cancer Cell ◽  
Graphene Quantum Dots ◽  
Maximum Effect ◽  
Cancer Cell Growth ◽  
Nitrogen Doped ◽  
Nitrogen Doped Graphene ◽  
Doped Graphene

With 18 million new cases diagnosed each year worldwide, cancer strongly impacts both science and society. Current models of cancer cell growth and therapeutic efficacy in vitro are time-dependent and often do not consider the Emax value (the maximum reduction in the growth rate), leading to inconsistencies in the obtained IC50 (concentration of the drug at half maximum effect). In this work, we introduce a new dual experimental/modeling approach to model HeLa and MCF-7 cancer cell growth and assess the efficacy of doxorubicin chemotherapeutics, whether alone or delivered by novel nitrogen-doped graphene quantum dots (N-GQDs). These biocompatible/biodegradable nanoparticles were used for the first time in this work for the delivery and fluorescence tracking of doxorubicin, ultimately decreasing its IC50 by over 1.5 and allowing for the use of up to 10 times lower doses of the drug to achieve the same therapeutic effect. Based on the experimental in vitro studies with nanomaterial-delivered chemotherapy, we also developed a method of cancer cell growth modeling that (1) includes an Emax value, which is often not characterized, and (2), most importantly, is measurement time-independent. This will allow for the more consistent assessment of the efficiency of anti-cancer drugs and nanomaterial-delivered formulations, as well as efficacy improvements of nanomaterial delivery.

Can graphene quantum dots cause DNA damage in cells?

Nanoscale ◽  
2015 ◽  
Vol 7 (21) ◽  
pp. 9894-9901 ◽  
Author(s):  
Dan Wang ◽  
Lin Zhu ◽  
Jian-Feng Chen ◽  
Liming Dai
Keyword(s):  
Dna Damage ◽  
Quantum Dots ◽  
Graphene Quantum Dots ◽  
In Cells

Graphene Quantum Dots-Coated Bismuth Nanoparticles for Improved CT Imaging and Photothermal Performance

2018 ◽  
Vol 19 (01) ◽  
pp. 1850043 ◽  
Author(s):  
Samireh Badrigilan ◽  
Behrouz Shaabani ◽  
Nahideh Ghareh Aghaji ◽  
Asghar Mesbahi
Keyword(s):  
Quantum Dots ◽  
Photothermal Therapy ◽  
High Performance ◽  
Blood Compatibility ◽  
Graphene Quantum Dots ◽  
Ct Imaging ◽  
Bismuth Nanoparticles ◽  
Contrast Ct ◽  
Absorbance Profile

By integrating high-performance CT imaging and photothermal therapy (PTT) into one nanoprobe, an effective theranostic can be achieved for clinical cancer treatment. In this study, the graphene quantum dots (GQDs)-coated bismuth (Bi) nanoparticle (NP) as a theranostic nanoprobe is synthesized and its capabilities for computed tomography (CT) imaging and PTT are investigated. Such nanotheranostic exhibits good physiological dispersity with satisfactory blood compatibility and cytotoxicity. Most importantly, the GQDs-Bi NPs offer strong and steady absorbance profile in NIR region with excellent photostability, which can remarkably convert photo-to-thermal with the photothermal efficiency of 30.0%. Thanks to the powerful PTT effect, co-delivery of GQDs-Bi NPs/NIR laser can effectively induce HeLa cells death in vitro. Cooperatively, NPs hold X-ray attenuation coefficient for high-contrast CT imaging with the corresponding CT improvement efficacy as high as 32.7[Formula: see text]HU[Formula: see text]mg[Formula: see text]. The obtained results highlight the potential of GQDs-Bi NPs as a successful theranostic nanoagent for CT imaging and cancer photothermal therapy.

scholarly journals Modulation of β-amyloid aggregation by graphene quantum dots

2019 ◽  
Vol 6 (6) ◽  
pp. 190271 ◽  
Author(s):  
Changliang Liu ◽  
Huan Huang ◽  
Lilusi Ma ◽  
Xiaocui Fang ◽  
Chen Wang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Structural Changes ◽  
Graphene Quantum Dots ◽  
Amyloid Peptide ◽  
Therapeutic Drug ◽  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Regulatory Effects ◽  
Β Amyloid Peptide

Misfolding and abnormal aggregation of β-amyloid peptide is associated with the onset and progress of Alzheimer's disease (AD). Therefore, modulating β-amyloid aggregation is critical for the treatment of AD. Herein, we studied the regulatory effects and mechanism of graphene quantum dots (GQDs) on 1–42 β-amyloid (Aβ 1–42 ) aggregation. GQDs displayed significant regulatory effects on the aggregation of Aβ 1–42 peptide as detected by thioflavin T (ThT) assay. Then, the changes of confirmations and structures induced by GQDs on the Aβ 1–42 aggregation were monitored by circular dichroism (CD), dynamic light scattering (DLS) and transmission electron microscope (TEM). The in vitro cytotoxicity experiments further demonstrated the feasibility of GQDs on the regulation of Aβ 1–42 aggregation. Meanwhile, the structural changes of a Aβ 1–42 /GQDs mixture in different pH revealed that electrostatic interaction was the major driving force in the co-assembly process of Aβ 1–42 and GQDs. The proposed mechanism of the regulatory effects of GQDs on the Aβ 1–42 aggregation was also deduced reasonably. This work not only demonstrated the potential feasibility of GQDs as therapeutic drug for AD but also clarified the regulatory mechanism of GQDs on the Aβ 1–42 aggregation.

GFP Plasmid and Chemoreagent Conjugated with Graphene Quantum Dots as a Novel Gene Delivery Platform for Colon Cancer Inhibition In Vitro and In Vivo

2020 ◽  
Vol 3 (9) ◽  
pp. 5948-5956
Author(s):  
Pei-Ying Lo ◽  
Guang-Yu Lee ◽  
Jia-Huei Zheng ◽  
Jen-Hsien Huang ◽  
Er-Chieh Cho ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Quantum Dots ◽  
Gene Delivery ◽  
Graphene Quantum Dots ◽  
Novel Gene ◽  
Delivery Platform ◽  
Cancer Inhibition

scholarly journals Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking In Vivo

Materials ◽  
2019 ◽  
Vol 12 (13) ◽  
pp. 2191 ◽  
Author(s):  
Yu Wang ◽  
Nan Xu ◽  
Yongkai He ◽  
Jingyun Wang ◽  
Dan Wang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Real Time ◽  
Fluorescent Dyes ◽  
Graphene Quantum Dots ◽  
Shell Nanoparticles ◽  
One Pot ◽  
Real Time Tracking

Fluorescence imaging offers a new approach to visualize real-time details on a cellular level in vitro and in vivo without radioactive damage. Poor light stability of organic fluorescent dyes makes long-term imaging difficult. Due to their outstanding optical properties and unique structural features, graphene quantum dots (GQDs) are promising in the field of imaging for real-time tracking in vivo. At present, GQDs are mainly loaded on the surface of nanoparticles. In this study, we developed an efficient and convenient one-pot method to load GQDs into nanoparticles, leading to longer metabolic processes in blood and increased delivery of GQDs to tumors. Optical-magneto ferroferric oxide@polypyrrole (Fe3O4@PPy) core-shell nanoparticles were chosen for their potential use in cancer therapy. The in vivo results demonstrated that by loading GQDs, it was possible to monitor the distribution and metabolism of nanoparticles. This study provided new insights into the application of GQDs in long-term in vivo real-time tracking.

scholarly journals Fabrication of highly fluorescent graphene quantum dots using l-glutamic acid for in vitro/in vivo imaging and sensing

2013 ◽  
Vol 1 (31) ◽  
pp. 4676 ◽  
Author(s):  
Xu Wu ◽  
Fei Tian ◽  
Wenxue Wang ◽  
Jiao Chen ◽  
Min Wu ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Glutamic Acid ◽  
In Vivo Imaging ◽  
Graphene Quantum Dots
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