Glutathione- and pH-responsive nonporous silica prodrug nanoparticles for controlled release and cancer therapy

Nanoscale ◽  
2015 ◽  
Vol 7 (13) ◽  
pp. 5859-5868 ◽  
Author(s):  
Zhigang Xu ◽  
Shiying Liu ◽  
Yuejun Kang ◽  
Mingfeng Wang
Keyword(s):  
Controlled Release ◽  
Cancer Therapy ◽  
Anticancer Drugs ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Silica Matrices

Stimuli-responsive nonporous silica prodrug nanoparticles are developed by covalently encapsulating anticancer drugs camptothecin (CPT) and doxorubicin (DOX) into silica matrices through glutathione (GSH)-responsive disulfide and pH-responsive hydrazone bonds.

scholarly journals Hyperthermia evaluation and drug/protein-controlled release using alternating magnetic field stimuli-responsive Mn–Zn ferrite composite particles

RSC Advances ◽  
2020 ◽  
Vol 10 (66) ◽  
pp. 40206-40214
Author(s):  
Wararat Montha ◽  
Weerakanya Maneeprakorn ◽  
I-Ming Tang ◽  
Weeraphat Pon-On
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Therapy ◽  
Regenerative Medicine ◽  
Alternating Magnetic Field ◽  
Composite Particles ◽  
Stimuli Responsive ◽  
Zn Ferrite

Drug delivery particles in which the release of biomolecules is triggered by a magnetic simulant have attracted much attention and may have great potential in the fields of cancer therapy and tissue regenerative medicine.

scholarly journals Synthesis of surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

MedChemComm ◽  
2017 ◽  
Vol 8 (9) ◽  
pp. 1797-1805 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Drug Delivery Applications

Herein, we propose a “host–guest” complexation-based mesoporous silica drug carrier, MSNs@Mela@TTM, for pH-responsive drug delivery applications in cancer therapy.

Diazonaphthoquinone-based amphiphilic polymer assemblies for NIR/UV light- and pH-responsive controlled release

2018 ◽  
Vol 9 (4) ◽  
pp. 463-471 ◽  
Author(s):  
Qingwei Li ◽  
Ziquan Cao ◽  
Guojie Wang
Keyword(s):  
Controlled Release ◽  
Uv Light ◽  
Amphiphilic Polymer ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Responsive Polymer ◽  
Self Assembled ◽  
Stimuli Responsive Polymer ◽  
Ph Controlled

A multiple-stimuli-responsive polymer nanocarrier has been self-assembled for NIR/UV light- and pH-controlled cargo release.

pH-responsive dendritic polyrotaxane drug-polymer conjugates forming nanoparticles as efficient drug delivery system for cancer therapy

2015 ◽  
Vol 6 (11) ◽  
pp. 2098-2107 ◽  
Author(s):  
Yang Kang ◽  
Xiao-Mei Zhang ◽  
Sheng Zhang ◽  
Li-Sheng Ding ◽  
Bang-Jing Li
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Polymer Conjugates

pH stimuli-responsive controlled selective release of drugs at the endosomal compartments of the PR-g-DOX supramolecular micelles.

scholarly journals Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 527 ◽  
Author(s):  
Sugata Barui ◽  
Valentina Cauda
Keyword(s):  
Controlled Release ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Cancer Therapeutics ◽  
High Loading ◽  
Active Targeting ◽  
Stimuli Responsive

The presence of leaky vasculature and the lack of lymphatic drainage of small structures by the solid tumors formulate nanoparticles as promising delivery vehicles in cancer therapy. In particular, among various nanoparticles, the mesoporous silica nanoparticles (MSN) exhibit numerous outstanding features, including mechanical thermal and chemical stability, huge surface area and ordered porous interior to store different anti-cancer therapeutics with high loading capacity and tunable release mechanisms. Furthermore, one can easily decorate the surface of MSN by attaching ligands for active targeting specifically to the cancer region exploiting overexpressed receptors. The controlled release of drugs to the disease site without any leakage to healthy tissues can be achieved by employing environment responsive gatekeepers for the end-capping of MSN. To achieve precise cancer chemotherapy, the most desired delivery system should possess high loading efficiency, site-specificity and capacity of controlled release. In this review we will focus on multimodal decorations of MSN, which is the most demanding ongoing approach related to MSN application in cancer therapy. Herein, we will report about the recently tried efforts for multimodal modifications of MSN, exploiting both the active targeting and stimuli responsive behavior simultaneously, along with individual targeted delivery and stimuli responsive cancer therapy using MSN.

Dual Stimuli‐Responsive Controlled Release Nanocarrier for Multidrug Resistance Cancer Therapy

ChemPhysChem ◽  
2019 ◽  
Vol 20 (24) ◽  
pp. 3271-3275
Author(s):  
Xiangyu Jiao ◽  
Zemin Wang ◽  
Fang Wang ◽  
Yongqiang Wen
Keyword(s):  
Multidrug Resistance ◽  
Controlled Release ◽  
Cancer Therapy ◽  
Stimuli Responsive

Unimolecular micelles of pH-responsive star-like copolymers for co-delivery of anticancer drugs and small-molecular photothermal agents: a new drug-carrier for combinational chemo/photothermal cancer therapy

2017 ◽  
Vol 5 (43) ◽  
pp. 8514-8524 ◽  
Author(s):  
Tao Jia ◽  
Shuo Huang ◽  
Cangjie Yang ◽  
Mingfeng Wang
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Therapeutic Effect ◽  
Anticancer Drugs ◽  
Drug Carrier ◽  
Ph Responsive ◽  
New Drug

Robust unimolecular micelles of amphiphilic pH-responsive starlike copolymers that carry anticancer drugs and photothermal agents show enhanced therapeutic effect against cancer cells.

scholarly journals Smart stimuli-responsive nanocarriers for the cancer therapy – nanomedicine

2021 ◽  
Vol 10 (1) ◽  
pp. 933-953
Author(s):  
Baranya Murugan ◽  
Suresh Sagadevan ◽  
Is Fatimah ◽  
Won-Chun Oh ◽  
Mohd Abd Motalib Hossain ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Release Profile ◽  
Acidic Ph ◽  
Stimuli Responsive ◽  
External Stimuli

Abstract Nanomedicine is ongoing current research in the applications of nanotechnology for cancer therapy. Simply from a technology perspective, this field of research has an enormous broadening and success to date. Recently, nanomedicine has also made inroads in the treatment of cancer. Stimuli-responsive nanoparticles are an emerging field of research because its targeting capacity is of great interest in the treatment of cancer. The responsive nanoparticles are efficient in encountering different internal biological stimuli (acidic, pH, redox, and enzyme) and external stimuli (temperature, ultrasounds, magnetic field, and light), which are used as smart nanocarriers for delivery of the chemotherapeutic and imaging agents for cancer therapy. In-depth, the responsive nanocarrier that responds to the biological cues is of pronounced interest due to its capability to provide a controlled release profile at the tumor-specific site. The outlook of this review focuses on the stimuli-responsive nanocarrier drug delivery systems in sequence to address the biological challenges that need to be evaluated to overcome conventional cancer therapy.

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