scholarly journals Iron oxide nanorods as high-performance magnetic resonance imaging contrast agents

Nanoscale ◽  
2015 ◽  
Vol 7 (20) ◽  
pp. 9174-9184 ◽  
Author(s):  
Jeotikanta Mohapatra ◽  
Arijit Mitra ◽  
Himanshu Tyagi ◽  
D. Bahadur ◽  
M. Aslam

An efficient magnetic resonance imaging (MRI) contrast agent with a highR2relaxivity value is achieved by controlling the shape of iron oxide to rod like morphology with a length of 30–70 nm and diameter of 4–12 nm.

2017 ◽  
Vol 8 (34) ◽  
pp. 5157-5166 ◽  
Author(s):  
A. V. Fuchs ◽  
A. P. Bapat ◽  
G. J. Cowin ◽  
K. J. Thurecht

A switchable polymeric 19F magnetic resonance imaging (MRI) contrast agent was synthesised whereby the transverse (T2) relaxation times increased as a therapeutic was released from a hyperbranched polymer (HBP) scaffold.


2010 ◽  
Vol 03 (03) ◽  
pp. 197-200 ◽  
Author(s):  
CHUNJIAO ZHOU ◽  
PENGFEI RONG ◽  
WENJIE ZHANG ◽  
JIANDA ZHOU ◽  
QINGLIN ZHANG ◽  
...  

Fulvic acid coated Fe 3 O 4 superparamagnetic nanoparticles were synthesized by a coprecipitation technique with iron salts and a small molecule stabilizer-fulvic acid. The prepared nanoparticles were well dispersed in water with about 10 nm in size according to transmission electron microscopy (TEM) observations. Fourier transform infrared spectroscopy (FTIR) revealed that fulvic acid were successfully covalently bonded to Fe 3 O 4 through the two adjacent phenolic hydroxyl groups and the carboxyl (- COOH ) groups were functionalized to the surface. The vibrating sample magnetometer (VSM) result showed that the nanoparticles were superparamagnetic and the saturation magnetizations were 60 emu/g. Moreover, their efficacy of liver magnetic resonance imaging (MRI) contrast agent was investigated by using live rat and tumor-bearing rabbit models through conventional clinical 1.5T MRI.


2016 ◽  
Vol 7 (14) ◽  
pp. 2531-2541 ◽  
Author(s):  
Chunhua Guo ◽  
Ling Sun ◽  
Wenchuan She ◽  
Ning Li ◽  
Lei Jiang ◽  
...  

An amphiphilic dendronized heparin–gadolinium conjugate self-assembles into a nanoscale system by a combination of the features of the nanoparticle, dendrimer and heparin. The nanoscale system demonstrates great potential as an efficient and safe MRI contrast agent.


2017 ◽  
Vol 5 (12) ◽  
pp. 2403-2415 ◽  
Author(s):  
Kun Liu ◽  
Xu Yan ◽  
Yun-Jun Xu ◽  
Liang Dong ◽  
Li-Na Hao ◽  
...  

It is a significant challenge to develop nanoscale magnetic resonance imaging (MRI) contrast agents with high performance of relaxation.


2018 ◽  
Vol 6 (40) ◽  
pp. 6413-6423 ◽  
Author(s):  
Juanjuan Li ◽  
Ruitao Cha ◽  
Yulong Zhang ◽  
Hongbo Guo ◽  
Keying Long ◽  
...  

Even though iron oxide (Fe3O4) nanoparticles are promising materials for magnetic resonance imaging (MRI) contrast agents, their biocompatibility and targeting efficacy still need to be improved.


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