Molecular imaging probes derived from natural peptides

2016 ◽  
Vol 33 (6) ◽  
pp. 761-800 ◽  
Author(s):  
C. L. Charron ◽  
J. L. Hickey ◽  
T. K. Nsiama ◽  
D. R. Cruickshank ◽  
W. L. Turnbull ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Therapeutic Agents ◽  
Imaging Agents ◽  
Target Specificity ◽  
Molecular Imaging Probes ◽  
Molecular Imaging Agents ◽  
Imaging Probes ◽  
Natural Peptides

Natural peptides possess a unique target specificity for their endogenous receptor that allows them to be exploited as diagnostic and therapeutic agents. This has led to the discovery and derivatization of various natural peptides into molecular imaging agents.

scholarly journals Target-responsive vasoactive probes for ultrasensitive molecular imaging

2019 ◽  
Author(s):  
Robert Ohlendorf ◽  
Agata Wiśniowska ◽  
Mitul Desai ◽  
Ali Barandov ◽  
Adrian L. Slusarczyk ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
The Body ◽  
Noninvasive Detection ◽  
Imaging Agents ◽  
Wide Field ◽  
Functional Magnetic Resonance ◽  
Deep Tissue ◽  
Vasoactive Peptides ◽  
Molecular Imaging Agents ◽  
Imaging Probes

ABSTRACTThe ability to monitor molecules volumetrically throughout the body could provide valuable biomarkers for studies of healthy function and disease, but noninvasive detection of molecular targets in living subjects often suffers from poor sensitivity or selectivity. Here we describe a family of potent imaging probes that can be activated by molecules of interest in deep tissue, providing a basis for mapping nanomolar-scale analytes without the radiation or heavy metal content associated with traditional molecular imaging agents. The probes are reversibly-caged vasodilators that induce responses detectable by hemodynamic imaging; they are constructed by combining vasoactive peptides with synthetic chemical appendages and protein blocking domains. We use this architecture to create ultrasensitive biotin-responsive imaging agents, which we apply for wide-field mapping of targets in rat brains using functional magnetic resonance imaging. We also adapt the sensor design for detecting the neurotransmitter dopamine, illustrating versatility of this approach for addressing biologically important molecules.

scholarly journals A Systematic Review of Molecular Imaging Agents Targeting Bradykinin B1 and B2 Receptors

2020 ◽  
Vol 13 (8) ◽  
pp. 199
Author(s):  
Joseph Lau ◽  
Julie Rousseau ◽  
Daniel Kwon ◽  
François Bénard ◽  
Kuo-Shyan Lin
Keyword(s):  
Molecular Imaging ◽  
Smooth Muscle Contraction ◽  
Therapeutic Interventions ◽  
Imaging Agents ◽  
Kinin System ◽  
Normal Tissues ◽  
Molecular Imaging Agents ◽  
Inflammatory State ◽  
B2 Receptors ◽  
Tissue Trauma

Kinins, bradykinin and kallidin are vasoactive peptides that signal through the bradykinin B1 and B2 receptors (B1R and B2R). B2R is constitutively expressed in healthy tissues and mediates responses such as vasodilation, fluid balance and retention, smooth muscle contraction, and algesia, while B1R is absent in normal tissues and is induced by tissue trauma or inflammation. B2R is activated by kinins, while B1R is activated by kinins that lack the C-terminal arginine residue. Perturbations of the kinin system have been implicated in inflammation, chronic pain, vasculopathy, neuropathy, obesity, diabetes, and cancer. In general, excess activation and signaling of the kinin system lead to a pro-inflammatory state. Depending on the disease context, agonism or antagonism of the bradykinin receptors have been considered as therapeutic options. In this review, we summarize molecular imaging agents targeting these G protein-coupled receptors, including optical and radioactive probes that have been used to interrogate B1R/B2R expression at the cellular and anatomical levels, respectively. Several of these preclinical agents, described herein, have the potential to guide therapeutic interventions for these receptors.

Functional MOFs as molecular imaging probes and theranostics

2020 ◽  
pp. 425-443
Author(s):  
Rajasekharreddy Pala ◽  
Subhaswaraj Pattnaik ◽  
Yun Zeng ◽  
Siddhardha Busi ◽  
Surya M. Nauli ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Molecular Imaging Probes ◽  
Imaging Probes

scholarly journals Techniques for Molecular Imaging Probe Design

2011 ◽  
Vol 10 (6) ◽  
pp. 7290.2011.00003 ◽  
Author(s):  
Fred Reynolds ◽  
Kimberly A. Kelly
Keyword(s):  
Molecular Imaging ◽  
Target Selection ◽  
Relevant Information ◽  
Probe Design ◽  
Imaging Probe ◽  
Molecular Imaging Probes ◽  
Genomics And Proteomics ◽  
Imaging Probes ◽  
Molecular Imaging Probe ◽  
Underlying Mechanisms

Molecular imaging allows clinicians to visualize disease-specific molecules, thereby providing relevant information in the diagnosis and treatment of patients. With advances in genomics and proteomics and underlying mechanisms of disease pathology, the number of targets identified has significantly outpaced the number of developed molecular imaging probes. There has been a concerted effort to bridge this gap with multidisciplinary efforts in chemistry, proteomics, physics, material science, and biology—all essential to progress in molecular imaging probe development. In this review, we discuss target selection, screening techniques, and probe optimization with the aim of developing clinically relevant molecularly targeted imaging agents.

Preparation and comparative evaluation of 99m Tc-HYNIC-cNGR and 99m Tc-HYNIC-PEG2 -cNGR as tumor-targeting molecular imaging probes

2018 ◽  
Vol 61 (2) ◽  
pp. 68-76 ◽  
Author(s):  
Kusum Vats ◽  
Drishty Satpati ◽  
Rohit Sharma ◽  
Chandan Kumar ◽  
Haladhar Dev Sarma ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Comparative Evaluation ◽  
Tumor Targeting ◽  
Molecular Imaging Probes ◽  
Imaging Probes
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