scholarly journals Techniques for Molecular Imaging Probe Design

2011 ◽  
Vol 10 (6) ◽  
pp. 7290.2011.00003 ◽  
Author(s):  
Fred Reynolds ◽  
Kimberly A. Kelly
Keyword(s):  
Molecular Imaging ◽  
Target Selection ◽  
Relevant Information ◽  
Probe Design ◽  
Imaging Probe ◽  
Molecular Imaging Probes ◽  
Genomics And Proteomics ◽  
Imaging Probes ◽  
Molecular Imaging Probe ◽  
Underlying Mechanisms

Molecular imaging allows clinicians to visualize disease-specific molecules, thereby providing relevant information in the diagnosis and treatment of patients. With advances in genomics and proteomics and underlying mechanisms of disease pathology, the number of targets identified has significantly outpaced the number of developed molecular imaging probes. There has been a concerted effort to bridge this gap with multidisciplinary efforts in chemistry, proteomics, physics, material science, and biology—all essential to progress in molecular imaging probe development. In this review, we discuss target selection, screening techniques, and probe optimization with the aim of developing clinically relevant molecularly targeted imaging agents.

CLIC1 antibody conjugated nanoscale contrast agent as a sensitive and targeted molecular imaging probe for gallbladder cancer diagnosis

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24104-24110 ◽  
Author(s):  
Wei Lu ◽  
Ning Wang ◽  
YanYan Chu ◽  
Linzhu Zhou ◽  
Maolan Li ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Gallbladder Cancer ◽  
Cancer Diagnosis ◽  
Imaging Probe ◽  
Molecular Imaging Probes ◽  
Imaging Probes ◽  
Molecular Imaging Probe ◽  
Targeted Molecular Imaging

CLIC1 antibody-conjugated nano-scale contrast agents exhibit a fast and sensitive detection of gallbladder tumors and may be used in the future as powerful targeted molecular imaging probes for gallbladder cancer diagnosis.

scholarly journals Multimodal Imaging Probe for Melanoma Evaluating of PTK7 Expression by Sgc8-c Aptamer Recognition

2021 ◽  
Author(s):  
Estefanía Sicco ◽  
Amy Mónaco ◽  
Marcelo Fernandez ◽  
María Moreno ◽  
Victoria Calzada ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Dna Aptamer ◽  
Specific Expression ◽  
Imaging Probe ◽  
Molecular Imaging Probes ◽  
Imaging Probes ◽  
Diagnosis Of Cancer ◽  
Animal Tumor

Abstract Melanoma is one of the most aggressive and deadly skin cancers, and although histopathological criteria are used for its prognosis, biomarkers are necessary to identify the different evolution stages. The applications of molecular imaging include the in vivo diagnosis of cancer with probes that recognize the tumor-biomarkers specific expression allowing external images acquisitions and evaluations of the biological process in quali-quantitative ways. Aptamers are oligonucleotides that recognize targets with high affinity and specificity presenting advantages that make them interesting molecular imaging probes. Sgc8-c (DNA-aptamer) selectively recognizes PTK7-receptor overexpressed in various types of tumors. Herein, Sgc8-c was evaluated, in two melanoma models, non-metastatic and metastatic, as molecular imaging probe for in vivo diagnostic. Firstly, two probes, radio- and fluorescent-probe, were in vitro evaluated verifying the high specific PTK7 recognition and its internalization in tumor cells by the endosomal route. Secondly, in vivo proof of concept was performed in animal tumor models. Likewise, they have rapid clearance from blood exhibiting excellent target (tumor)/non-target organ ratios. Furthermore, optimal biodistribution was observed 24 hours after probes-injections accumulating almost exclusively in the tumor tissue. Sgc8-c is a potential tool for their specific use in the early detection of melanoma.

scholarly journals Metallic nanoparticles as synthetic building blocks for cancer diagnostics: from materials design to molecular imaging applications

2015 ◽  
Vol 3 (28) ◽  
pp. 5657-5672 ◽  
Author(s):  
Vincenzo Mirabello ◽  
David G. Calatayud ◽  
Rory L. Arrowsmith ◽  
Haobo Ge ◽  
Sofia I. Pascu
Keyword(s):  
Molecular Imaging ◽  
Medical Diagnosis ◽  
Metallic Nanoparticles ◽  
Building Blocks ◽  
Cancer Diagnostics ◽  
Probe Design ◽  
Degenerative Diseases ◽  
Imaging Probe ◽  
Molecular Imaging Probe ◽  
Synthetic Scaffolds

New perspectives on the efficiency of metallic nanoparticles as synthetic scaffolds for molecular imaging probe design and their use in medical diagnosis of degenerative diseases such as cancer.

Functional MOFs as molecular imaging probes and theranostics

2020 ◽  
pp. 425-443
Author(s):  
Rajasekharreddy Pala ◽  
Subhaswaraj Pattnaik ◽  
Yun Zeng ◽  
Siddhardha Busi ◽  
Surya M. Nauli ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Molecular Imaging Probes ◽  
Imaging Probes

Preparation and comparative evaluation of 99m Tc-HYNIC-cNGR and 99m Tc-HYNIC-PEG2 -cNGR as tumor-targeting molecular imaging probes

2018 ◽  
Vol 61 (2) ◽  
pp. 68-76 ◽  
Author(s):  
Kusum Vats ◽  
Drishty Satpati ◽  
Rohit Sharma ◽  
Chandan Kumar ◽  
Haladhar Dev Sarma ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Comparative Evaluation ◽  
Tumor Targeting ◽  
Molecular Imaging Probes ◽  
Imaging Probes
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