Forced degradation of lafutidine and characterization of its non-volatile and volatile degradation products using LC-MS/TOF, LC-MSn and HS-GC-MS

2015 ◽  
Vol 39 (12) ◽  
pp. 9679-9692 ◽  
Author(s):  
Shah Kinalkumar Pravinchandra ◽  
Moolchand Kurmi ◽  
Sanjay Kumar ◽  
Saranjit Singh
Keyword(s):  
Degradation Products ◽  
Forced Degradation ◽  
Degradation Behaviour ◽  
Intrinsic Degradation

The study involved establishment of the intrinsic degradation behaviour of lafutidine under hydrolytic, oxidative and photolytic conditions.

Study of forced degradation behaviour of cobicistat and atazanavir using LC/ESI/QTOF/MS; a combination of in-sourced and collision-induced dissociation for evaluation of the fragmentation patterns of degradation products

2018 ◽  
Vol 42 (23) ◽  
pp. 19113-19128
Author(s):  
Shandilya Mahamuni Baira ◽  
Padmini Gunupudi ◽  
Vigjna Abbaraju ◽  
Srinivas R. ◽  
M. V. N. Kumar Talluri
Keyword(s):  
Degradation Products ◽  
Collision Induced Dissociation ◽  
Forced Degradation ◽  
Degradation Behaviour ◽  
Fragmentation Patterns

The present study describes the LC/MS/MS characterization of degradation products of cobicistat and atazanavir.

Stability behaviour of antiretroviral drugs and their combinations. 1: characterization of tenofovir disoproxil fumarate degradation products by mass spectrometry

RSC Advances ◽  
2015 ◽  
Vol 5 (116) ◽  
pp. 96117-96129 ◽  
Author(s):  
Moolchand Kurmi ◽  
Vijaya Madhyanapu Golla ◽  
Sanjay Kumar ◽  
Archana Sahu ◽  
Saranjit Singh
Keyword(s):  
Mass Spectrometry ◽  
Tenofovir Disoproxil Fumarate ◽  
Degradation Products ◽  
Antiretroviral Drugs ◽  
Degradation Behaviour ◽  
Stability Behaviour ◽  
Intrinsic Degradation

The investigation established the intrinsic degradation behaviour of tenofovir disoproxil fumarate in solid and solution states.

Synthesis and Characterization of Potential and Degraded Impurities of Regadenoson

2020 ◽  
Vol 16 (8) ◽  
pp. 1130-1139
Author(s):  
Singaram Sathiyanarayanan ◽  
Chidambaram Subramanian Venkatesan ◽  
Senthamaraikannan Kabilan
Keyword(s):  
Mass Spectra ◽  
Degradation Products ◽  
Hplc Method ◽  
Forced Degradation ◽  
Spectroscopic Techniques ◽  
A2a Adenosine Receptor ◽  
Degradation Study ◽  
Related Substances ◽  
Adenosine Receptor Agonist

Background: Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator and commonly used as a pharmacologic cardiac stressing agents. Methods: HPLC method was used for the analysis of related substances. The degraded impurities during the process were isolated and characterized by IR, Mass and NMR spectral analysis. Results: Forced degradation study of regadenoson under conditions of hydrolysis (neutral, acidic and alkaline) and oxidations suggested in the ICH Q1A(R2) was accomplished. The drug showed significant degradation under all the above conditions. On the whole, five novel degradation products were found under diverse conditions along with process related impurities which were not reported earlier. Conclusion: All the degradation products were well characterized by using advanced spectroscopic techniques like IR, 1H NMR, 13C NMR and Mass spectra. The identification of these impurities will be productive for the quality control during the production and stability behavior of the regadenoson drug substance.

LC-MS/MS method for the characterization of the forced degradation products of Entecavir

2014 ◽  
Vol 37 (4) ◽  
pp. 368-375 ◽  
Author(s):  
Thippani Ramesh ◽  
Pothuraju Nageswara Rao ◽  
Ramisetti Nageswara Rao
Keyword(s):  
Degradation Products ◽  
Forced Degradation

Identification and structural characterization of the stress degradation products of omeprazole using Q-TOF-LC-ESI-MS/MS and NMR experiments: evaluation of the toxicity of the degradation products

2019 ◽  
Vol 43 (19) ◽  
pp. 7294-7306 ◽  
Author(s):  
G. Shankar ◽  
Roshan M. Borkar ◽  
Suresh Udutha ◽  
M. Kanakaraju ◽  
G. Sai Charan ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Proton Pump Inhibitor ◽  
Gastroesophageal Reflux ◽  
Degradation Products ◽  
Forced Degradation ◽  
Peptic Ulcers ◽  
Ich Guidelines ◽  
Stress Degradation ◽  
Forced Degradation Studies

Omeprazole (OMP), a prototype proton pump inhibitor used for the treatment of peptic ulcers and gastroesophageal reflux disease (GERD), was subjected to forced degradation studies as per ICH guidelines Q1A (R2).

scholarly journals Characterization of forced degradation products of toloxatone by LC-ESI-MS/MS

2018 ◽  
Vol 26 (4) ◽  
pp. 467-480 ◽  
Author(s):  
Robert Skibiński ◽  
Jakub Trawiński ◽  
Łukasz Komsta ◽  
Diana Murzec
Keyword(s):  
Degradation Products ◽  
Forced Degradation ◽  
Esi Ms
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