Synthesis and biological evaluation of novel 7-O-lipophilic substituted baicalein derivatives as potential anticancer agents

MedChemComm ◽  
2015 ◽  
Vol 6 (10) ◽  
pp. 1864-1873 ◽  
Author(s):  
Shao-Hung Wang ◽  
Ching-Hsein Chen ◽  
Chih-Yu Lo ◽  
Ji-Zhen Feng ◽  
Hong-Jhih Lin ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

A series of lipophilic 7-O-substituted baicalein derivatives were synthesized and evaluated for their anticancer activity.

scholarly journals Synthesis and Biological Evaluation of 1,3,4-Oxadiazole Fused Resveratrol Derivatives as Anticancer Agents

2020 ◽  
Vol 32 (8) ◽  
pp. 1967-1971
Author(s):  
Vema Venkata Naresh ◽  
Y. Bharathi Kumari ◽  
Mussulla Sridhar ◽  
Addada Ramakrishnam Raju ◽  
A. Srinivasa Rao
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agents ◽  
Human Cancer ◽  
Positive Control ◽  
Biological Evaluation ◽  
Human Cancer Cell Lines ◽  
Control Drug ◽  
Novel Target ◽  
Synthesis And Biological Evaluation ◽  
A549 Lung

A novel target compounds (9a-j) were design and synthesized and characterized by 1H & 13C NMR, ESI-MS spectral analysis. Further, these were tested for their anticancer activity against three human cancer cell lines such as MCF-7, MDA MB-231 (breast), A549 (Lung) and adriamycin was used as positive control. Among ten compounds, two compounds like 9b and 9j were showed a significant anticancer activity compared to control drug.

Design, synthesis, and biological evaluation of pyrazole-linked aloe emodin derivatives as potential anticancer agents

2021 ◽  
Author(s):  
Guddeti Dileep Kumar ◽  
Bandi Siva ◽  
Sravanthi Vadlamudi ◽  
Surendar Reddy Bathula ◽  
Hashnu Dutta ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Lead Compounds ◽  
Traditional Medicinal Plants ◽  
Aloe Emodin ◽  
Synthesis And Biological Evaluation

In connection with our continuous efforts to generate new derivatives from lead compounds isolated from traditional medicinal plants, a series of aloe-emodin derivatives were synthesized and assessed for potential anticancer activity against a panel of cancer cell lines.

scholarly journals Synthesis and biological evaluation of 4-(1H-1,2,4-triazol-1-yl)benzoic acid hybrids as anticancer agents

RSC Advances ◽  
2019 ◽  
Vol 9 (33) ◽  
pp. 19065-19074 ◽  
Author(s):  
Hatem A. Abuelizz ◽  
Hanem M. Awad ◽  
Mohamed Marzouk ◽  
Fahd A. Nasr ◽  
Ali S. Alqahtani ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Anticancer Activity ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Ms Analysis ◽  
Normal Human ◽  
Hct 116 ◽  
Synthesis And Biological Evaluation ◽  
Mcf 7

A series of 4-(1H-1,2,4-triazol-1-yl)benzoic acid hybrids (1–17) was successfully synthesized and their structures were established by NMR and MS analysis. Their anticancer activity against HCT-116, MCF-7 and normal human RPE-1 cells were examined.

Synthesis and Biological Evaluation of 1,3,4-Thiadiazole Linked Phthalimide Derivatives as Anticancer Agents

2017 ◽  
Vol 14 (10) ◽  
Author(s):  
Zahra Rezaei ◽  
Setareh Moghimi ◽  
Rezvan Javaheri ◽  
Mehdi Asadi ◽  
Mohammad Mahdavi ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Design, Synthesis and Biological Evaluation of Tetrahydrodibenzo[b,g][1,8]napthyridinones as Potential Anticancer Agents and Novel Aurora Kinases Inhibitors

2021 ◽  
Vol 6 (14) ◽  
pp. 3444-3452
Author(s):  
Asha V. Chate ◽  
Pramod A. Tagad ◽  
Giribala M. Bondle ◽  
Aniket P. Sarkate ◽  
Shailee V. Tiwari ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Aurora Kinases ◽  
Synthesis And Biological Evaluation

scholarly journals Molecular modeling study, synthesis and biological evaluation of combretastatin A-4 analogues as anticancer agents and tubulin inhibitors

MedChemComm ◽  
2018 ◽  
Vol 9 (2) ◽  
pp. 316-327 ◽  
Author(s):  
Yang Ping Quan ◽  
Li Ping Cheng ◽  
Tian Chi Wang ◽  
Wan Pang ◽  
Fan Hong Wu ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Anticancer Agents ◽  
Hepg2 Cells ◽  
Binding Mode ◽  
Biological Evaluation ◽  
Tubulin Inhibitors ◽  
Molecular Modeling Study ◽  
Synthesis And Biological Evaluation ◽  
Modeling Study

Compound 13a, more effective than CA-4 against HepG2 cells and tubulin, and the proposed binding mode for 13a.

Synthesis and biological evaluation of novel withangulatin A derivatives as potential anticancer agents

2021 ◽  
Vol 108 ◽  
pp. 104690
Author(s):  
Wu-Xi Zhou ◽  
Chen Chen ◽  
Xiao-Qin Liu ◽  
Ying Li ◽  
Ling-Yi Kong ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation
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