An insight into antagonist binding and induced conformational dynamics of class B GPCR corticotropin-releasing factor receptor 1

2015 ◽  
Vol 11 (7) ◽  
pp. 2042-2050 ◽  
Author(s):  
Junli Xu ◽  
Zhonghua Wang ◽  
Pi Liu ◽  
Dongmei Li ◽  
Jianping Lin
Keyword(s):  
Small Molecule ◽  
Conformational Dynamics ◽  
Corticotropin Releasing Factor ◽  
Class B ◽  
Antagonist Binding ◽  
Insight Into ◽  
Class B Gpcr

The binding of small-molecule antagonists, CP-376395 and MTIP, would induce conformational dynamics behaviors of CRF1R.

Structure of class B GPCR corticotropin-releasing factor receptor 1

Nature ◽  
2013 ◽  
Vol 499 (7459) ◽  
pp. 438-443 ◽  
Author(s):  
Kaspar Hollenstein ◽  
James Kean ◽  
Andrea Bortolato ◽  
Robert K. Y. Cheng ◽  
Andrew S. Doré ◽  
...  
Keyword(s):  
Corticotropin Releasing Factor ◽  
Class B ◽  
Class B Gpcr

scholarly journals Study of Live Lecture Attendance, Student Perceptions and Expectations

2021 ◽  
Author(s):  
Johnathan Emahiser ◽  
John Nguyen ◽  
Cheryl Vanier ◽  
Amina Sadik
Keyword(s):  
Student Perceptions ◽  
Teaching Practices ◽  
First Year ◽  
First Year Students ◽  
Study Materials ◽  
Class B ◽  
Second Year ◽  
To Come ◽  
Perceptions And Expectations ◽  
Insight Into

AbstractDeclining lecture attendance has been an ongoing concern for educators involved in undergraduate medical education. A survey was developed (a) to gain insight into the reasons students skipped class, (b) to identify the type of study materials they were using, and (c) to determine what they thought would motivate them to come to class. The survey was sent to 317 first-year and second-year medical students, and 145 (45%) responded. Only 63% of first-year students and 53% of second-year students attended any lectures that were not mandatory. The attendance was higher for students who aspired to less competitive specialties such as pediatrics and family medicine. The most popular reasons for not coming to class were related to the efficiency of information intake and instructor or class style. The most heavily used resources (> 60%) were materials or recorded lectures provided by the instructor. The second-year students also heavily used outside study materials for Board exams, such as Pathoma (50%). Students’ ideas for what might increase their attendance suggest that they perceive that the lectures may not prepare them for Board exams, and they would like faculty to address Board related content more often in class and on assessments. Respondents also suggested that teaching practices might be improved through faculty development. Faculty awareness of and references to Board exam content, embedded in strong teaching practices, may help students find more value in live lectures. Carefully designed active learning sessions may change students’ minds regarding the relevance and value of these sessions.

scholarly journals Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism

Structure ◽  
2010 ◽  
Vol 18 (9) ◽  
pp. 1083-1093 ◽  
Author(s):  
Ernst ter Haar ◽  
Christopher M. Koth ◽  
Norzehan Abdul-Manan ◽  
Lora Swenson ◽  
Joyce T. Coll ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Cgrp Receptor ◽  
Class B ◽  
Drug Antagonism ◽  
Class B Gpcr
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