Mechanical differences of sickle cell trait (SCT) and normal red blood cells

Lab on a Chip ◽  
2015 ◽  
Vol 15 (15) ◽  
pp. 3138-3146 ◽  
Author(s):  
Yi Zheng ◽  
Mark A. Cachia ◽  
Ji Ge ◽  
Zhensong Xu ◽  
Chen Wang ◽  
...  
Keyword(s):  
Shear Modulus ◽  
Red Blood Cells ◽  
Sickle Cell ◽  
Blood Cells ◽  
Sickle Cell Trait ◽  
Oxygen Conditions

Shear modulus and viscosity of sickle cell trait red blood cells and normal RBCs were measured under controlled oxygen conditions.

scholarly journals Elastic property of sickle cell anemia and sickle cell trait red blood cells

2021 ◽  
Vol 26 (09) ◽  
Author(s):  
Endris Muhammed ◽  
James Cooper ◽  
Daniel Devito ◽  
Robert Mushi ◽  
Maria del Pilar Aguinaga ◽  
...  
Keyword(s):  
Elastic Property ◽  
Red Blood Cells ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Blood Cells ◽  
Sickle Cell Trait

scholarly journals Valsartan impedes epinephrine-induced ICAM-4 activation on normal, sickle cell trait and sickle cell disease red blood cells

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0216467
Author(s):  
Jing Zhang ◽  
Sasia-Marie Jones ◽  
George Lykotrafitis ◽  
Biree Andemariam
Keyword(s):  
Sickle Cell Disease ◽  
Red Blood Cells ◽  
Sickle Cell ◽  
Blood Cells ◽  
Sickle Cell Trait ◽  
Cell Disease

Novel Optical Signature for Sickle Cell Trait Red Blood Cells

2012 ◽  
Author(s):  
Lisa L. Satterwhite ◽  
Natan T. Shaked ◽  
Derek D. Cyr ◽  
Marilyn J. Telen ◽  
George A. Truskey ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Sickle Cell ◽  
Blood Cells ◽  
Sickle Cell Trait ◽  
Optical Signature

Increased Complement Deposition on Red Blood Cells in Children with Sickle Cell Trait

2015 ◽  
Vol 5 (4) ◽  
pp. 457-465
Author(s):  
Walter Otieno ◽  
Benson Estambale ◽  
Michael Odera ◽  
Collins Odhiambo ◽  
Joash Aluoch ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Sickle Cell ◽  
Blood Cells ◽  
Sickle Cell Trait ◽  
Complement Deposition

scholarly journals Stage-dependent fate of Plasmodium falciparum-infected red blood cells in the spleen and sickle-cell trait-related protection against malaria

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Seidina A. S. Diakité ◽  
Papa Alioune Ndour ◽  
Valentine Brousse ◽  
Frederick Gay ◽  
Camille Roussel ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Red Blood Cells ◽  
Sickle Cell ◽  
Blood Cells ◽  
Sickle Cell Trait

scholarly journals High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria

2020 ◽  
Author(s):  
Huan Cao ◽  
Aristotelis Antonopoulos ◽  
Sadie Henderson ◽  
Heather Wassall ◽  
John Brewin ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Red Blood Cells ◽  
Sickle Cell ◽  
Blood Cells ◽  
Sickle Cell Anaemia ◽  
Sickle Cell Trait ◽  
Mannose Receptor ◽  
Cell Disease ◽  
High Mannose ◽  
Haemoglobin S

AbstractIn both sickle cell disease (SCD) and malaria, red blood cells (RBCs) are phagocytosed in the spleen, but receptor-ligand pairs mediating uptake have not been identified. Here, we report that patches of high mannose N-glycans (Man5-9GlcNAc2), expressed on diseased or oxidized RBC surfaces, bind the mannose receptor (CD206) on phagocytes to mediate clearance. Extravascular haemolysis in SCD correlates with high mannose glycan levels on RBCs. Infection of RBCs with Plasmodium falciparum expose surface mannose N-glycans on healthy RBCs, which occurred at significantly higher levels on RBCs from subjects with sickle cell trait compared to those lacking haemoglobin S. The glycans were associated with high molecular weight complexes and protease-resistant, lower molecular weight fragments containing spectrin. Recognition of surface N-linked high mannose glycans, a novel response to cellular stress, is the first molecular mechanism common to both the pathogenesis of SCD and resistance to severe malaria in sickle cell trait.

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